Detailed description page of Selected OV_ID


OV_4484 details
Primary information
OV_IDOV_4484
Virus Name Herpes simplex virus
StrainRH2
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeMutant for Gamma 34.5 gene and gB gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineMurine squamous cell carcinoma
Cell lineSCCVII
Concentration of cell line0
In-vitro toxicityNA
AssayMTT assay
In-vitro virus concentration10 MOI
In-vitro result60% cell survival after 12 hours
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionVirus induced apoptosis
Immunogenic effectIncreased extracellular ATP and HMGB1, indicating immunogenic cell death
Clinical trialNA
PMID26987291