Detailed description page of Selected OV_ID


OV_3156 details
Primary information
OV_IDOV_3156
Virus Name Herpes simplex virus
StrainSPDD-UG
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeVirus expressing SNORD44 gene and GAS5 gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineCell bank of type culture collection of chinese academy of science
Origin of cell lineHuman colon carcinoma cell line
Cell lineLS174T
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismMouse model xenograft for LS174T (1 × 10⁶)
In-vivo virus concentration5 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume below 500mm as compared to control 3000mm after 24 days
Mode of deliveryIntratumoral
Pathway inductionCaspase dependent Induction of apoptosis as measured by TUNEL assay in both tumor model and cell line
Immunogenic effectNA
Clinical trialNA
PMID28530127