Detailed description page of Selected OV_ID


OV_4473 details
Primary information
OV_IDOV_4473
Virus Name Herpes simplex virus
StrainG47-delta
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeDeletion mutant for Gamma 34.5, alpha47 and LacZ insertion inactivating ICP6
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismSCID mice orthotopic xenograft for MN3 cell (75000 cells)
In-vivo virus concentration2 × 10⁶ pfu on day 14 and 25 post tumor cell implantation
In-vivo toxicityNA
In-vivo resultSurvival time increased from control 80 days to 160 days in virus trated group
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID26951380