Detailed description page of Selected OV_ID


OV_4489 details
Primary information
OV_IDOV_4489
Virus Name Herpes simplex virus
StrainRH2
Virus typeDNA
Virus familyHerpesviridae
Modification in virus genomeMutant for Gamma 34.5 gene and gB gene
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismC3H mice subcutaneous implanted for SCCVII (1 × 10⁶)
In-vivo virus concentration50 microliter of RH2 virus, 3 times at interval of 2 days
In-vivo toxicityNA
In-vivo resultTumor volume was less than 1587 cubic mm in treated mice compared to control 2996 cubic mm after 25 days
Mode of deliveryIntratumoral
Pathway inductionVirus induced apoptosis
Immunogenic effectIncreased extracellular ATP and HMGB1, indicating immunogenic cell death
Clinical trialNA
PMID26987291