Browse By Oncolytic Virus Species Result Page of OvirusTdb

The Total number of records shown on this page is 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_4999	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	Yes	No	Virus expressing human GM-CSF gene	DSMZ Germany	Human epitheliod mesothelioma	JL-1	1.0E+4 cells per well	NA	MTS assay	10 VP per cell	80% cell viability after 3 days	No	No	NA	No response	NA	Virus induce apoptosis	NA	NA	27287512
OV_5000	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	Yes	No	Virus expressing human GM-CSF gene	DSMZ Germany	Human epitheliod mesothelioma	JL-1	1.0E+4 cells per well	NA	MTS assay	100 VP per cell	40% cell viability after 3 days	No	No	NA	No response	NA	Virus induce apoptosis	NA	NA	27287512
OV_5001	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	Yes	No	Virus expressing human GM-CSF gene	DSMZ Germany	Human epitheliod mesothelioma	JL-1	1.0E+4 cells per well	NA	MTS assay	1000 VP per cell	20% cell viability after 3 days	No	No	NA	No response	NA	Virus induce apoptosis	NA	NA	27287512
OV_5002	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	Yes	No	Virus expressing human GM-CSF gene	NA	NA	NA	NA	NA	NA	NA	NA	Mice xenograft for NCI-H226 (1.0E+6 cells)	5.0E+7 VP per tumor	Tumor volume regressed to 0.40 FTV		Intratumoral	Virus induce apoptosis	NA	NA	27287512
OV_5003	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	No	Virus in combination with Pem 10 mg/kg + cis 1.5 mg/kg intrapertoneal on day 1 and 7	Virus expressing human GM-CSF gene	NA	NA	NA	NA	NA	NA	NA	NA	Mice xenograft for NCI-H226 (1.0E+6 cells)	5.0E+7 VP per tumor	Tumor volume regressed to 0.29 compared to control 0.40 FTV		Intratumoral	Virus induce apoptosis	NA	NA	27287512
OV_5004	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	Yes	Virus priming on day 1 and 7 combine with Prem 10mg/kg on day 4 and day 10 + cis 1.5 mg/kg on day 4 and 10	Virus expressing human GM-CSF gene	NA	NA	NA	NA	NA	NA	NA	NA	Mice xenograft for NCI-H226 (1.0E+6 cells)	5.0E+7 VP per tumor	Tumor volume regressed to 0.290compared to control 0.40 FTV		Intratumoral	Virus induce apoptosis	NA	NA	27287512
OV_5005	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	Yes	Virus in combination with Pem 10 mg/kg + car 8mg/kg intrapertoneal on day 1 and 7	Virus expressing human GM-CSF gene	NA	NA	NA	NA	NA	NA	NA	NA	Mice xenograft for NCI-H226 (1.0E+6 cells)	5.0E+7 VP per tumor	Tumor volume regressed to 0.35 compared to control 0.40 FTV		Intratumoral	Virus induce apoptosis	NA	NA	27287512
OV_5006	Adenovirus	ONCOS-102	DNA	Adenoviridae	Virus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF	Yes	Virus priming on day 1 and 7 combine with Prem 10mg/kg on day 4 and day 10 + cis 8 mg/kg on day 4 and 10	Virus expressing human GM-CSF gene	NA	NA	NA	NA	NA	NA	NA	NA	Mice xenograft for NCI-H226 (1.0E+6 cells)	5.0E+7 VP per tumor	Tumor volume regressed to 0.32 compared to control 0.40 FTV		Intratumoral	Virus induce apoptosis	NA	NA	27287512
OV_5072	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	1 MOI	100% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5073	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	2 MOI	98% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5074	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	4 MOI	70% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5075	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	8 MOI	60% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5076	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	16 MOI	55% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5077	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 5ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	1 MOI	55% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5078	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 10ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	2 MOI	45% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5079	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 20ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	4 MOI	30% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5080	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 40ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	8 MOI	20% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5081	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 80ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	BxPC-3	1.0E+4 cells per well	NA	MTT assay	16 MOI	10% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5082	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	PANC-1	1.0E+4 cells per well	NA	MTT assay	1 MOI	100% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5083	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	PANC-1	1.0E+4 cells per well	NA	MTT assay	2 MOI	80% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5084	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	PANC-1	1.0E+4 cells per well	NA	MTT assay	4 MOI	70% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5085	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	PANC-1	1.0E+4 cells per well	NA	MTT assay	8 MOI	60% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5086	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	No	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	PANC-1	1.0E+4 cells per well	NA	MTT assay	16 MOI	60% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5087	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 5ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	PANC-1	1.0E+4 cells per well	NA	MTT assay	1 MOI	70% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5088	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 10ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	PANC-1	1.0E+4 cells per well	NA	MTT assay	2 MOI	60% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5089	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 20ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	PANC-1	1.0E+4 cells per well	NA	MTT assay	4 MOI	50% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5090	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 40ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	PANC-1	1.0E+4 cells per well	NA	MTT assay	8 MOI	40% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5091	Adenovirus	ZD-55-TRAIl-IETD-smac	DNA	Adenoviridae	Addition of TRAIL and smac gene via IETD linker	Yes	Virus in combination with SNS032 80ng/ml	Virus expressing TRAIL gene	Shanghai cell collection	Human pancreatic cancer cell line	PANC-1	1.0E+4 cells per well	NA	MTT assay	16 MOI	30% cell viability	No	No	NA	No response	NA	Induction of apoptosis	Induction of Interferon related gene expression	NA	28440486
OV_5156	Adenovirus	Ad-ZD55-miR143	DNA	Adenoviridae	Insertion of miR143 in adenovirus via homologus recombination	Yes	No	No	Chinese academy of science	Human colorectal cancer cell line	SW480	NA	NA	Crystal violet staining	0.01 MOI	100% cell viability	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27725862
OV_5157	Adenovirus	Ad-ZD55-miR143	DNA	Adenoviridae	Insertion of miR143 in adenovirus via homologus recombination	Yes	No	No	Chinese academy of science	Human colorectal cancer cell line	SW480	NA	NA	Crystal violet staining	0.5 MOI	50% cell viability	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27725862
OV_5158	Adenovirus	Ad-ZD55-miR143	DNA	Adenoviridae	Insertion of miR143 in adenovirus via homologus recombination	Yes	No	No	Chinese academy of science	Human colorectal cancer cell line	SW480	NA	NA	Crystal violet staining	1 MOI	30% cell viability	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27725862
OV_5159	Adenovirus	Ad-ZD55-miR143	DNA	Adenoviridae	Insertion of miR143 in adenovirus via homologus recombination	Yes	No	No	Chinese academy of science	Human colorectal cancer cell line	SW480	NA	NA	Crystal violet staining	10 MOI	100% cell killing	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27725862
OV_5196	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5197	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5198	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5199	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5200	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5201	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5202	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5203	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	60% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5204	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human epithelia carcinoma cell line	HeLa	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	10% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5205	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5206	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5207	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5208	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5209	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5210	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5211	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5212	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5213	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	HepG2	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	20% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5214	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5215	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5216	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5217	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5218	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5219	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5220	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5221	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5222	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	20% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5223	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for H1299 (2.0E+6 cells)	1.0E+7 pfu	NA	No significant reduction in tumor volume compared to control	Intratumoral	NA	NA	NA	27760834
OV_5224	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for H1299 (2.0E+6 cells)	1.0E+7 pfu	NA	No significant reduction in tumor volume compared to control	Intratumoral	NA	NA	NA	27760834
OV_5225	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for H1299 (2.0E+6 cells)	1.0E+7 pfu	NA	Reduction in tumor volume to 1000 cubic mm after 35 days compared to control 6000 cubic mm	Intratumoral	NA	NA	NA	27760834
OV_5226	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for SKOV3 (2.0E+6 cells)	1.0E+7 pfu	NA	Reduction in tumor volume to 2500 cubic mm after 45 days compared to control 3500 cubic mm	Intratumoral	NA	NA	NA	27760834
OV_5227	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for SKOV3 (2.0E+6 cells)	1.0E+7 pfu	NA	Reduction in tumor volume to 2500 cubic mm after 45 days compared to control 3500 cubic mm	Intratumoral	NA	NA	NA	27760834
OV_5228	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for SKOV3 (2.0E+6 cells)	1.0E+7 pfu	NA	Reduction in tumor volume to 800 cubic mm after 45 days compared to control 3500 cubic mm	Intratumoral	NA	NA	NA	27760834
OV_5312	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	0.1 MOI	100% cell viability on day 1	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5313	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	0.1 MOI	90% cell viability on day 2	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5314	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	0.1 MOI	87% cell viability on day 3	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5315	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	0.1 MOI	80% cell viability on day 4	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5316	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	1 MOI	90% cell viability on day 1	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5317	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	1 MOI	82% cell viability on day 2	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5318	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	1 MOI	78% cell viability on day 3	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5319	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	1 MOI	65% cell viability on day 4	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5320	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	82% cell viability on day 1	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5321	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	78% cell viability on day 2	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5322	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	62% cell viability on day 3	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5323	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	42% cell viability on day 4	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5324	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	100 MOI	70% cell viability on day 1	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5325	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	100 MOI	58% cell viability on day 2	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5326	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	100 MOI	50% cell viability on day 3	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5327	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	Yes	No	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	100 MOI	30% cell viability on day 4	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5328	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	No	Virus in combination with DTIC 200 microgram per ml	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	65% cell viability on day 1	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5329	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	No	Virus in combination with DTIC 200 microgram per ml	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	52% cell viability on day 2	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5330	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	No	Virus in combination with DTIC 200 microgram per ml	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	38% cell viability on day 3	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5331	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	No	Virus in combination with DTIC 200 microgram per ml	Virus expressing IL18 gene	NA	Human skin melanoma cell line	A375	NA	NA	MTT assay	10 MOI	30% cell viability on day 4	No	No	NA	No response	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5332	Adenovirus	ZD55-IL18	DNA	Adenoviridae	virus having insertion of IL18 gene	No	Virus in combination with DTIC 100 microgram per ml	Virus expressing IL18 gene	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for A375 (2.0E+6)	10 MOI	NA	Reduction in tumor volume to 250 cubic mm after six week compared to control 800 cubic mm	NA	Virus induced apoptosis as measured by TUNEL assay	NA	NA	27895465
OV_5345	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	Yes	No	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	5.0E+3 cells per well	NA	MTT assay	1 MOI	78% cell viability after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5346	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	Yes	No	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	5.0E+3 cells per well	NA	MTT assay	2 MOI	78% cell viability after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5347	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with gemcitabine 0.01 micromoar	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	5.0E+3 cells per well	NA	MTT assay	1 MOI	60% cells remain viable after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5348	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with gemcitabine 0.01 micromoar	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	5.0E+3 cells per well	NA	MTT assay	2 MOI	50% cells remain viable after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5349	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with gemcitabine 0.05 micromoar	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	5.0E+3 cells per well	NA	MTT assay	1 MOI	35% cells remain viable after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5350	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with gemcitabine 0.05 micromoar	No	ATCC	Human pancreatic cancer cell line	MIAPaCa-2	5.0E+3 cells per well	NA	MTT assay	2 MOI	30% cells remain viable after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5351	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	Yes	No	No	ATCC	Human pancreatic cancer cell line	PANC-1	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	100% cell viability after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5352	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	Yes	No	No	ATCC	Human pancreatic cancer cell line	PANC-1	5.0E+3 cells per well	NA	MTT assay	0.5 MOI	100% cell viability after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5353	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with gemcitabine 0.01 micromoar	No	ATCC	Human pancreatic cancer cell line	PANC-1	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	70% cell viability after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5354	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with gemcitabine 0.01 micromoar	No	ATCC	Human pancreatic cancer cell line	PANC-1	5.0E+3 cells per well	NA	MTT assay	0.5 MOI	68% cell viability after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5355	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with gemcitabine 0.05 micromoar	No	ATCC	Human pancreatic cancer cell line	PANC-1	5.0E+3 cells per well	NA	MTT assay	0.1 MOI	65% cell viability after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5356	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	No	Virus in combination with gemcitabine 0.05 micromoar	No	ATCC	Human pancreatic cancer cell line	PANC-1	5.0E+3 cells per well	NA	MTT assay	0.5 MOI	50% cell viability after 72 hours	No	No	NA	No response	NA	Virus induced apoptosis	NA	NA	28315430
OV_5357	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for 3.0E+5 MIAPaCa2	2.0E+6 pfu	NA	Reduction in tumor volume to 1700 cubic mm after 60 days compared to 2700 cubic mm	Intratumoral	Virus induced apoptosis	NA	NA	28315430
OV_5358	Adenovirus	YDC002	DNA	Adenoviridae	Virus having insertion mutant for relaxin gene	Yes	No	No	NA	NA	NA	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for 5.0E+5 BxPC3	2.0E+6 pfu	NA	Reduction in tumor volume to 1000 cubic mm after 60 days compared to 2700 cubic mm	Intratumoral	Virus induced apoptosis	NA	NA	28315430

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