Detailed description page of Selected OV_ID


OV_5087 details
Primary information
OV_IDOV_5087
Virus Name Adenovirus
StrainZD-55-TRAIl-IETD-smac
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeAddition of TRAIL and smac gene via IETD linker
Virus aloneYes
Virus in combination iwth drug/radiationVirus in combination with SNS032 5ng/ml
Immune gene induction in virus genomeVirus expressing TRAIL gene
Source of cell lineShanghai cell collection
Origin of cell lineHuman pancreatic cancer cell line
Cell linePANC-1
Concentration of cell line1
In-vitro toxicityNA
AssayMTT assay
In-vitro virus concentration1 MOI
In-vitro result70% cell viability
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionInduction of apoptosis
Immunogenic effectInduction of Interferon related gene expression
Clinical trialNA
PMID28440486