Detailed description page of Selected OV_ID


OV_5006 details
Primary information
OV_IDOV_5006
Virus Name Adenovirus
StrainONCOS-102
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeVirus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF
Virus aloneYes
Virus in combination iwth drug/radiationVirus priming on day 1 and 7 combine with Prem 10mg/kg on day 4 and day 10 + cis 8 mg/kg on day 4 and 10
Immune gene induction in virus genomeVirus expressing human GM-CSF gene
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismMice xenograft for NCI-H226 (1× 10⁶ cells)
In-vivo virus concentration5× 10⁷ VP per tumor
In-vivo toxicityTumor volume regressed to 0.32 compared to control 0.40 FTV
In-vivo result
Mode of deliveryIntratumoral
Pathway inductionVirus induce apoptosis
Immunogenic effectNA
Clinical trialNA
PMID27287512