Detailed description page of Selected OV_ID


OV_5000 details
Primary information
OV_IDOV_5000
Virus Name Adenovirus
StrainONCOS-102
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeVirus having 24 bp deletion in Rb binding site of E1A region and consisting of chmeric capsid protein and Human GM-CSF
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing human GM-CSF gene
Source of cell lineDSMZ Germany
Origin of cell lineHuman epitheliod mesothelioma
Cell lineJL-1
Concentration of cell line1
In-vitro toxicityNA
AssayMTS assay
In-vitro virus concentration100 VP per cell
In-vitro result40% cell viability after 3 days
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionVirus induce apoptosis
Immunogenic effectNA
Clinical trialNA
PMID27287512