Detailed description page of Selected OV_ID


OV_5228 details
Primary information
OV_IDOV_5228
Virus Name Adenovirus
StrainTRAD-shDICER
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeVirus having shorthairpin RNA for DICER
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for SKOV3 (2 × 10⁶ cells)
In-vivo virus concentration1 × 10⁷ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 800 cubic mm after 45 days compared to control 3500 cubic mm
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID27760834