Detailed description page of Selected OV_ID


OV_5332 details
Primary information
OV_IDOV_5332
Virus Name Adenovirus
StrainZD55-IL18
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomevirus having insertion of IL18 gene
Virus aloneNo
Virus in combination iwth drug/radiationVirus in combination with DTIC 100 microgram per ml
Immune gene induction in virus genomeVirus expressing IL18 gene
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismBALB/c nude mice xenograft for A375 (2 × 10⁶)
In-vivo virus concentration10 MOI
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 250 cubic mm after six week compared to control 800 cubic mm
Mode of deliveryNA
Pathway inductionVirus induced apoptosis as measured by TUNEL assay
Immunogenic effectNA
Clinical trialNA
PMID27895465