Please click on the ID to see detailed information about each entry.
The total number entries retrieved from this search are| ID1495 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporine | Nature of peptide or cargoCyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | AssayRadioimmunoassay | Tissue permeabilityNegative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Serum:55±125ng/ml, Aqueous humor:168±184 and Cornea:432±150ng/ml | Tissue SampleEyes of New Zealand white rabbits | PUBMED ID3977661 |
| ID1496 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporine | Nature of peptide or cargoCyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | AssayRadioimmunoassay | Tissue permeabilityNegative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Serum:68±100ng/ml, Aqueous humor:46±27 and Cornea:762±330ng/ml | Tissue SampleEyes of New Zealand white rabbits | PUBMED ID3977661 |
| ID1497 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporine | Nature of peptide or cargoCyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | AssayRadioimmunoassay | Tissue permeabilityNegative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Serum:87±153ng/ml, Aqueous humor:68±49 and Cornea:926±384ng/ml | Tissue SampleEyes of New Zealand white rabbits | PUBMED ID3977661 |
| ID1498 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporine | Nature of peptide or cargoCyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | AssayRadioimmunoassay | Tissue permeabilityNegative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Serum:75±75ng/ml, Aqueous humor:62±35 and Cornea:557±194ng/ml | Tissue SampleEyes of New Zealand white rabbits | PUBMED ID3977661 |
| ID1499 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporine | Nature of peptide or cargoCyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | AssayRadioimmunoassay | Tissue permeabilityNegative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Cornea:584±90ng/ml | Tissue SampleEyes of New Zealand white rabbits | PUBMED ID3977661 |
| ID1500 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporine | Nature of peptide or cargoCyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | AssayRadioimmunoassay | Tissue permeabilityNegative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Serum:0±19ng/ml, Aqueous humor:24±12and Cornea:672±275ng/ml | Tissue SampleEyes of New Zealand white rabbits | PUBMED ID3977661 |
| ID1502 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporine | Nature of peptide or cargoCyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | AssaySecretoneurin (SN) is detected in 10-100µl of aqueous humor, aspirated immediately before surgery by radioimmunoassay | Tissue permeabilitySecretoneurin-like immunoreactivities were detectable and averaged 474.24 fmol/ml (±34.4) in the Cy A group. | Tissue SampleHuman patients(8 eyes) undergoing cataract surgery belonging to 39-91 years of age | PUBMED ID15572199 |
| ID1517 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporin A (CysA) bearing reverse cubic phase | Nature of peptide or cargoCyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | AssayFranz diffusion cell, HPLC | Tissue permeabilityAmount of applied dose/cm2 present in stratum corneum=1.8%, 1.0%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=0.3%, 0.35%(Control) | Tissue SampleIn-vitro model of porcine ear skin | PUBMED ID16621488 |
| ID1518 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporin A (CysA) bearing reverse cubic phase | Nature of peptide or cargoCyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | AssayFranz diffusion cell, HPLC | Tissue permeabilityAmount of applied dose/cm2 present in stratum corneum=2.9%, 1.3%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=0.41%, 0.38%(Control) | Tissue SampleIn-vitro model of porcine ear skin | PUBMED ID16621488 |
| ID1519 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporin A (CysA) bearing reverse cubic phase | Nature of peptide or cargoCyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | AssayFranz diffusion cell, HPLC | Tissue permeabilityAmount of applied dose/cm2 present in stratum corneum=7.0%, 1.9%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=1.2%, 0.7%(Control) | Tissue SampleIn-vitro model of porcine ear skin | PUBMED ID16621488 |
| ID1520 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporin A (CysA) bearing reverse hexagonal phase | Nature of peptide or cargoCyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | AssayFranz diffusion cell, HPLC | Tissue permeabilityAmount of applied dose/cm2 present in stratum corneum=0.9%, 1%(Control) | Tissue SampleIn-vitro model of porcine ear skin | PUBMED ID16621488 |
| ID1521 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporin A (CysA) bearing reverse hexagonal phase | Nature of peptide or cargoCyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | AssayFranz diffusion cell, HPLC | Tissue permeabilityAmount of applied dose/cm2 present in stratum corneum=1.5%, 1.3%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=1.1%, 0.38%(Control) | Tissue SampleIn-vitro model of porcine ear skin | PUBMED ID16621488 |
| ID1522 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporin A (CysA) bearing reverse hexagonal phase | Nature of peptide or cargoCyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | AssayFranz diffusion cell, HPLC | Tissue permeabilityAmount of applied dose/cm2 present in stratum corneum=2.0%, 1.9%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=1.5%, 0.7%(Control) | Tissue SampleIn-vitro model of porcine ear skin | PUBMED ID16621488 |
| ID1523 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporin A (CysA) bearing reverse cubic phase | Nature of peptide or cargoCyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | AssayHPLC | Tissue permeabilityAmount of applied dose/cm2 present in stratum corneum=2.75%, 1.1±0.13%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=1.1%, 0.61±0.09%(Control) | Tissue SampleSkin(Stratum corneum and Epidermis without stratum corneum + dermis) of hairless mice | PUBMED ID16621488 |
| ID1524 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporin A (CysA) bearing reverse hexagonal phase | Nature of peptide or cargoCyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | AssayHPLC | Tissue permeabilityAmount of applied dose/cm2 present in stratum corneum=1.89%, 1.1±0.13%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=1.6%, 0.61±0.09%(Control) | Tissue SampleSkin(Stratum corneum and Epidermis without stratum corneum + dermis) of hairless mice | PUBMED ID16621488 |
| ID1605 | SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporin A | Nature of peptide or cargoNot mentioned | AssayFranz 2-type vertical diffusion model. | Tissue permeabilitySkin permiation efficiency of CsA-loaded SLN was 2 fold higher than that of CsA-oil mixture in viable skin. | Tissue SampleMurine skin | PUBMED ID19746839 |
| ID1657 | SequenceAa-MeLeu-MeLeu-MeVal- 3-hydroxy-N,4-dimethyl-L-2-amino- 6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | NameCyclosporine | Nature of peptide or cargoNot mentioned | AssayDual-color fluorescence microscopy. | Tissue permeabilityThe inflammation was healed in the treated ear. | Tissue Samplemouse and human skin | PUBMED ID11062537 |