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Details of TopicalPdb ID 1499

PRIMARY INFORMATION
ID1499
PMID3977661
Year1985
SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl-
L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu
NameCyclosporine
Length11
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicCyclic (head to tail)
ChiralityMix
Chemical ModificationAbu= amino butyric acid, MeLeu=N-methyl-Leucine, MeVal=N-methyl-Valine
Origin of PeptideAn immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum.
Nature of Peptide/CargoCyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential
MechanismAn immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum.
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayRadioimmunoassay
EnhancerIntracardiac injection of thiopental sodium (Pentothal)
Properties of enhancerto kill the animals at specific times after drug Administration
Concentration10% Cyclosporine ointment to make 3 mg/kg of body weight
Incubation time5 hours
Tissue permeability (value with units)Negative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Cornea:584±90ng/ml
Tissue SampleEyes of New Zealand white rabbits
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.