PRIMARY INFORMATION |
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ID | 1496 |
PMID | 3977661 |
Year | 1985 |
Sequence | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu |
Name | Cyclosporine |
Length | 11 |
N-Terminal Modification | Free |
C-Terminal Modification | Free |
Linear/ Cyclic | Cyclic (head to tail) |
Chirality | Mix |
Chemical Modification | Abu= amino butyric acid, MeLeu=N-methyl-Leucine, MeVal=N-methyl-Valine |
Origin of Peptide | An immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum. |
Nature of Peptide/Cargo | Cyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential |
Mechanism | An immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum. |
Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
Assay | Radioimmunoassay |
Enhancer | Intracardiac injection of thiopental sodium (Pentothal) |
Properties of enhancer | to kill the animals at specific times after drug Administration |
Concentration | 10% Cyclosporine ointment to make 3 mg/kg of body weight |
Incubation time | 2 hours |
Tissue permeability (value with units) | Negative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Serum:68±100ng/ml, Aqueous humor:46±27 and Cornea:762±330ng/ml |
Tissue Sample | Eyes of New Zealand white rabbits |
Ex vivo/In vivo/In vitro | in vivo |
SECONDARY INFORMATION |
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STRUCTURE | |
SMILES | N.A. |