| PRIMARY INFORMATION |
|---|
| ID | 1605 |
| PMID | 19746839 |
| Year | 2009 |
| Sequence | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl-
L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu |
| Name | Cyclosporin A |
| Length | 11 |
| N-Terminal Modification | Free |
| C-Terminal Modification | Free |
| Linear/ Cyclic | Cyclic (head to tail) |
| Chirality | Mix |
| Chemical Modification | Abu= amino butyric acid, MeLeu=N-methyl-Leucine, MeVal=N-methyl-Valine |
| Origin of Peptide | An immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum. |
| Nature of Peptide/Cargo | Not mentioned |
| Mechanism | Not mentioned |
| Cargo Sequence/Structure | Solid Lipid Nano particles |
Name of cargo
| Not applicable |
| Assay | Franz 2-type vertical diffusion model. |
| Enhancer | PBS,pH 5.5 |
| Properties of enhancer | Not mentioned |
| Concentration | CsA loaded solid nano lipid particles were apprpximately 25 nm in size |
| Incubation time | 24 hours |
| Tissue permeability (value with units) | Skin permiation efficiency of CsA-loaded SLN was 2 fold higher than that of CsA-oil mixture in viable skin. |
| Tissue Sample | Murine skin |
| Ex vivo/In vivo/In vitro | in vitro |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
