PRIMARY INFORMATION |
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ID | 1517 |
PMID | 16621488 |
Year | 2006 |
Sequence | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu |
Name | Cyclosporin A (CysA) bearing reverse cubic phase |
Length | 11 |
N-Terminal Modification | Free |
C-Terminal Modification | Free |
Linear/ Cyclic | Cyclic (head to tail) |
Chirality | Mix |
Chemical Modification | Abu= amino butyric acid, MeLeu=N-methyl-Leucine, MeVal=N-methyl-Valine |
Origin of Peptide | An immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum. |
Nature of Peptide/Cargo | Cyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent |
Mechanism | An immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum. |
Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
Assay | Franz diffusion cell, HPLC |
Enhancer | Not mentioned |
Properties of enhancer | Not mentioned |
Concentration | 100mg (Monoolein:Cyclosporin A:Water=67:4:29/Control=Cyclosporin A in olive oil 4% w/w) |
Incubation time | 3 hours |
Tissue permeability (value with units) | Amount of applied dose/cm2 present in stratum corneum=1.8%, 1.0%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=0.3%, 0.35%(Control) |
Tissue Sample | In-vitro model of porcine ear skin |
Ex vivo/In vivo/In vitro | in vitro |
SECONDARY INFORMATION |
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STRUCTURE | |
SMILES | N.A. |