Details of TopicalPdb ID 1517
| ID | 1517 | |
| PMID | 16621488 | |
| Year | 2006 | |
| Sequence | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | |
| Name | Cyclosporin A (CysA) bearing reverse cubic phase | |
| Length | 11 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Cyclic (head to tail) | |
| Chirality | Mix | |
| Chemical Modification | Abu= amino butyric acid, MeLeu=N-methyl-Leucine, MeVal=N-methyl-Valine | |
| Origin of Peptide | An immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum. | |
| Nature of Peptide/Cargo | Cyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent | |
| Mechanism | An immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum. | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Franz diffusion cell, HPLC | |
| Enhancer | Not mentioned | |
| Properties of enhancer | Not mentioned | |
| Concentration | 100mg (Monoolein:Cyclosporin A:Water=67:4:29/Control=Cyclosporin A in olive oil 4% w/w) | |
| Incubation time | 3 hours | |
| Tissue permeability (value with units) | Amount of applied dose/cm2 present in stratum corneum=1.8%, 1.0%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=0.3%, 0.35%(Control) | |
| Tissue Sample | In-vitro model of porcine ear skin | |
| Ex vivo/In vivo/In vitro | in vitro | |
| STRUCTURE |
| |
| SMILES | N.A. | |