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Details of TopicalPdb ID 1523

PRIMARY INFORMATION
ID1523
PMID16621488
Year2006
SequenceAa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl-
L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu
NameCyclosporin A (CysA) bearing reverse cubic phase
Length11
N-Terminal ModificationFree
C-Terminal ModificationFree
Linear/ CyclicCyclic (head to tail)
ChiralityMix
Chemical ModificationAbu= amino butyric acid, MeLeu=N-methyl-Leucine, MeVal=N-methyl-Valine
Origin of PeptideAn immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum.
Nature of Peptide/CargoCyclic and highly lipophilic peptide that presents poor skin penetration capacity and works as an immune-suppressant agent
MechanismAn immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum.
Cargo Sequence/StructureNone
Name of cargo
Not applicable
AssayHPLC
EnhancerNot mentioned
Properties of enhancerNot mentioned
Concentration100mg (Monoolein:Cyclosporin A:Water=67:4:29/Control=Cyclosporin A in olive oil 4% w/w)
Incubation time6 hours
Tissue permeability (value with units)Amount of applied dose/cm2 present in stratum corneum=2.75%, 1.1±0.13%(Control); Amount of applied dose/cm2 present in epidermis without stratum corneum + dermis=1.1%, 0.61±0.09%(Control)
Tissue SampleSkin(Stratum corneum and Epidermis without stratum corneum + dermis) of hairless mice
Ex vivo/In vivo/In vitroin vivo
SECONDARY INFORMATION
STRUCTURE
Predicted Structure
SMILESN.A.