| PRIMARY INFORMATION |
|---|
| ID | 1495 |
| PMID | 3977661 |
| Year | 1985 |
| Sequence | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl-
L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu |
| Name | Cyclosporine |
| Length | 11 |
| N-Terminal Modification | Free |
| C-Terminal Modification | Free |
| Linear/ Cyclic | Cyclic (head to tail) |
| Chirality | Mix |
| Chemical Modification | Abu= amino butyric acid, MeLeu=N-methyl-Leucine, MeVal=N-methyl-Valine |
| Origin of Peptide | An immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum. |
| Nature of Peptide/Cargo | Cyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential |
| Mechanism | An immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum. |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Radioimmunoassay |
| Enhancer | Intracardiac injection of thiopental sodium (Pentothal) |
| Properties of enhancer | to kill the animals at specific times after drug Administration |
| Concentration | 10% Cyclosporine ointment to make 3 mg/kg of body weight |
| Incubation time | 1 hour |
| Tissue permeability (value with units) | Negative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Serum:55±125ng/ml, Aqueous humor:168±184 and Cornea:432±150ng/ml |
| Tissue Sample | Eyes of New Zealand white rabbits |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
