Details of TopicalPdb ID 1495
| ID | 1495 | |
| PMID | 3977661 | |
| Year | 1985 | |
| Sequence | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl- L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu | |
| Name | Cyclosporine | |
| Length | 11 | |
| N-Terminal Modification | Free | |
| C-Terminal Modification | Free | |
| Linear/ Cyclic | Cyclic (head to tail) | |
| Chirality | Mix | |
| Chemical Modification | Abu= amino butyric acid, MeLeu=N-methyl-Leucine, MeVal=N-methyl-Valine | |
| Origin of Peptide | An immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum. | |
| Nature of Peptide/Cargo | Cyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential | |
| Mechanism | An immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum. | |
| Cargo Sequence/Structure | None | |
| Name of cargo | Not applicable | |
| Assay | Radioimmunoassay | |
| Enhancer | Intracardiac injection of thiopental sodium (Pentothal) | |
| Properties of enhancer | to kill the animals at specific times after drug Administration | |
| Concentration | 10% Cyclosporine ointment to make 3 mg/kg of body weight | |
| Incubation time | 1 hour | |
| Tissue permeability (value with units) | Negative control- Serum:94±38ng/ml, Aqueous humor:12±21ng/ml, Cornea:38±39ng/ml; Cyclosporine concentration after incubation time- Serum:55±125ng/ml, Aqueous humor:168±184 and Cornea:432±150ng/ml | |
| Tissue Sample | Eyes of New Zealand white rabbits | |
| Ex vivo/In vivo/In vitro | in vivo | |
| STRUCTURE |
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| SMILES | N.A. | |