| PRIMARY INFORMATION |
|---|
| ID | 1502 |
| PMID | 15572199 |
| Year | 2004 |
| Sequence | Aa-MeLeu-MeLeu-MeVal-3-hydroxy-N,4-dimethyl-
L-2-amino-6-octenoyl-Abu-MeGly-MeLeu-V-MeLeu |
| Name | Cyclosporine |
| Length | 11 |
| N-Terminal Modification | Free |
| C-Terminal Modification | Free |
| Linear/ Cyclic | Cyclic (head to tail) |
| Chirality | Mix |
| Chemical Modification | Abu= amino butyric acid, MeLeu=N-methyl-Leucine, MeVal=N-methyl-Valine |
| Origin of Peptide | An immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum. |
| Nature of Peptide/Cargo | Cyclosporine is a neutral, hydrophobic, cyclic and fungal metabolite with potent immunosuppressive activity and novel immunologic potential |
| Mechanism | An immune-suppressant obtained from a type of soil fungus, Tolypocladium inflatum. |
| Cargo Sequence/Structure | None |
Name of cargo
| Not applicable |
| Assay | Secretoneurin (SN) is detected in 10-100µl of aqueous humor, aspirated immediately before surgery by radioimmunoassay |
| Enhancer | dimethylsulphoxide (DMSO) |
| Properties of enhancer | Solutions were dissolved in dimethylsulphoxide (DMSO) |
| Concentration | 2% Cyclosporine A once a day with tobramycine |
| Incubation time | Dose given once a day until 12 hours before cataract surgery |
| Tissue permeability (value with units) | Secretoneurin-like immunoreactivities were detectable and averaged 474.24 fmol/ml (±34.4) in the Cy A group. |
| Tissue Sample | Human patients(8 eyes) undergoing cataract surgery belonging to 39-91 years of age |
| Ex vivo/In vivo/In vitro | in vivo |
| SECONDARY INFORMATION |
|---|
| STRUCTURE | |
| SMILES | N.A. |
