Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_2048 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | NA | NAIP | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 28063015 | 2017 | NA |
| PRRID_2048 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | NA | NAIP | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 28063015 | 2017 | NA |
| PRRID_2152 | Hemozoin Click for more detail | Plasmodium falciparum (others) | CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5] | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Plasmodium falciparum-infected erythro- cytes, that co-purifies with the parasite product hemozoin, stimulates NOD2 in a RIP2/CARD9- dependent manner to drive nitric oxide production by macrophages | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | Macrophages | nucleotide-binding oligomerization domain | Q8K3Z0.fasta | Q8K3Z0 | 1020 | Hemozoin-mediated induction of NOS | NA | 28823510 | 2017 | Pubchem_assay |
| PRRID_2152 | Hemozoin Click for more detail | Plasmodium falciparum (others) | CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N+]4=[Fe])C=C5C(=C(C(=N5)C=C1[N-]2)C=C)C)C=C)C)C(=C3CCC(=O)[O-])C)CCC(=O)O.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.CC1=C(C2=CC3=NC(=CC4=C(C(=C([N-]4)C=C5C(=C(C(=N5)C=C1[N-]2)C)CCC(=O)O)CCC(=O)[O-])C)C(=C3C)C=C)C=C.[Fe+5].[Fe+5].[Fe+5].[Fe+5] | NA | Pattern-associated molecular patterns (PAMPs) | Natural | Plasmodium falciparum-infected erythro- cytes, that co-purifies with the parasite product hemozoin, stimulates NOD2 in a RIP2/CARD9- dependent manner to drive nitric oxide production by macrophages | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | Macrophages | nucleotide-binding oligomerization domain | Q8K3Z0.fasta | Q8K3Z0 | 1020 | Hemozoin-mediated induction of NOS | NA | 28823510 | 2017 | Pubchem_assay |
| PRRID_2155 | hepta- noyl-d-Glu-meso-DAP-d-Ala (FK565) Click for more detail | NA | CC(C)(C)OC(=O)CCC(C(=O)O)NC(=O)OC(C)(C)C | NA | Agonist | Synthetic | Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokines | Nod-like receptor C1 (NLRC1) | NOD-like receptor (NLR) | Human | Intracellular | C-terminal leucine-rich regions and NOD domains | NA | NA | NA | triggering production of β-defensins via an NF-κB signaling pathway | NA | 28776416 | 2017 | NA |
| PRRID_2155 | hepta- noyl-d-Glu-meso-DAP-d-Ala (FK565) Click for more detail | NA | CC(C)(C)OC(=O)CCC(C(=O)O)NC(=O)OC(C)(C)C | NA | Agonist | Synthetic | Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokines | Nod-like receptor C1 (NLRC1) | NOD-like receptor (NLR) | Human | Intracellular | C-terminal leucine-rich regions and NOD domains | NA | NA | NA | triggering production of β-defensins via an NF-κB signaling pathway | NA | 28776416 | 2017 | NA |
| PRRID_2160 | Histone Click for more detail | Nucleus (others) | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | nvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 29290139 | 2017 | NA |
| PRRID_2160 | Histone Click for more detail | Nucleus (others) | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | nvolved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 29290139 | 2017 | NA |
| PRRID_2199 | Hyaluronan Click for more detail | NA | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | Induce the production of TNF-α, IL-1β and IL-12 by dendritic cells | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | dendritic cells | NA | Q96P20.fasta | Q96P20 | 1036 | NA | NA | 28961019 | 2017 | Pubchem_assay |
| PRRID_2199 | Hyaluronan Click for more detail | NA | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | Induce the production of TNF-α, IL-1β and IL-12 by dendritic cells | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | dendritic cells | NA | Q96P20.fasta | Q96P20 | 1036 | NA | NA | 28961019 | 2017 | Pubchem_assay |
| PRRID_2202 | Hyaluronic acid Click for more detail | NA | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | Induce the maturation of mouse and human dendritic cells, | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Endothelial cells | NA | Q96P20.fasta | Q96P20 | 1036 | NA | NA | 28961019 | 2017 | Pubchem_assay |
| PRRID_2202 | Hyaluronic acid Click for more detail | NA | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | Induce the maturation of mouse and human dendritic cells, | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Endothelial cells | NA | Q96P20.fasta | Q96P20 | 1036 | NA | NA | 28961019 | 2017 | Pubchem_assay |
| PRRID_2207 | Hyaluronic acid Click for more detail | NA | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | Induce the production of TNF-α, IL-1β and IL-12 by dendritic cells | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Endothelial cells | NA | Q96P20.fasta | Q96P20 | 1036 | NA | NA | 28961019 | 2017 | Pubchem_assay |
| PRRID_2207 | Hyaluronic acid Click for more detail | NA | CC(=O)NC1CC(C(OC1OC2C(C(C(OC2C(=O)[O-])O)O)O)CO)O | NA | Damage-associated molecular patterns (DAMPs) | Natural | Induce the production of TNF-α, IL-1β and IL-12 by dendritic cells | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Endothelial cells | NA | Q96P20.fasta | Q96P20 | 1036 | NA | NA | 28961019 | 2017 | Pubchem_assay |
| PRRID_2208 | IgA protease (ST-11 N. meningitidis) Click for more detail | NA | NA | NA | NA | Natural | Apoptosis in epithelial cells | Nf-κb (intracellular signalling) | NOD-like receptor (NLR) | NA | (Cytoplasmic /nuclear) | NA | NA | NA | NA | NA | NA | 28334203 | 2017 | NA |
| PRRID_2208 | IgA protease (ST-11 N. meningitidis) Click for more detail | NA | NA | NA | NA | Natural | Apoptosis in epithelial cells | Nf-κb (intracellular signalling) | NOD-like receptor (NLR) | NA | (Cytoplasmic /nuclear) | NA | NA | NA | NA | NA | NA | 28334203 | 2017 | NA |
| PRRID_2213 | intracellular bacterial lipopolysaccharides (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | NA | Nucleotide-binding oligomerization domain 1 | Q9Y239.fasta | Q9Y239 | 953 | NA | NA | 29066255 | 2017 | Pubchem_assay |
| PRRID_2213 | intracellular bacterial lipopolysaccharides (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | NA | Nucleotide-binding oligomerization domain 1 | Q9Y239.fasta | Q9Y239 | 953 | NA | NA | 29066255 | 2017 | Pubchem_assay |
| PRRID_2214 | intracellular bacterial lipopolysaccharides (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | NA | Nucleotide-binding oligomerization domain 2, | Q9HC29.fasta | Q9HC29 | 1040 | NA | NA | 29066255 | 2017 | Pubchem_assay |
| PRRID_2214 | intracellular bacterial lipopolysaccharides (LPS) Click for more detail | Bacteria | CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC | NA | Lipopolysaccharide (LPS) | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | NA | Nucleotide-binding oligomerization domain 2, | Q9HC29.fasta | Q9HC29 | 1040 | NA | NA | 29066255 | 2017 | Pubchem_assay |
| PRRID_2308 | LMW-HA Click for more detail | Glycosaminoglycan (others) | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 29290139 | 2017 | NA |
| PRRID_2308 | LMW-HA Click for more detail | Glycosaminoglycan (others) | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 29290139 | 2017 | NA |
| PRRID_2313 | ATP Click for more detail | Bacteria | C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O | NA | Protein | Natural | NA | NALP3/ cryopyrin | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 28063015 | 2017 | NA |
| PRRID_2313 | ATP Click for more detail | Bacteria | C1=NC2=C(C(=N1)N)N=CN2C3C(C(C(O3)COP(=O)(O)OP(=O)(O)OP(=O)(O)O)O)O | NA | Protein | Natural | NA | NALP3/ cryopyrin | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 28063015 | 2017 | NA |
| PRRID_2321 | M-Tri-DAP Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)N | NA | Peptidoglycan | Synthetic | Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokines | Nod-like receptor C2 (NLRC2) | NOD-like receptor (NLR) | Human | Intracellular | C-terminal leucine-rich regions and NOD domains | NA | NA | NA | triggering production of β-defensins via an NF-κB signaling pathway | NA | 28776416 | 2017 | NA |
| PRRID_2321 | M-Tri-DAP Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)NC(CCCC(C(=O)O)N)C(=O)O)C(=O)O)N | NA | Peptidoglycan | Synthetic | Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokines | Nod-like receptor C2 (NLRC2) | NOD-like receptor (NLR) | Human | Intracellular | C-terminal leucine-rich regions and NOD domains | NA | NA | NA | triggering production of β-defensins via an NF-κB signaling pathway | NA | 28776416 | 2017 | NA |
| PRRID_2332 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 28801521 | 2017 | NA |
| PRRID_2332 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 28801521 | 2017 | NA |
| PRRID_2333 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor protein 1 (NLRP1) | NOD-like receptor (NLR) | Rat | Hippocampus | NA | D9I2G4 .fasta | D9I2G4 | 1218 | NLRP1 inflammasome activation in aging | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2333 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor protein 1 (NLRP1) | NOD-like receptor (NLR) | Rat | Hippocampus | NA | D9I2G4 .fasta | D9I2G4 | 1218 | NLRP1 inflammasome activation in aging | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2334 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Microglia | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | NLRP3 inflammasome activation in AD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2334 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Microglia | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | NLRP3 inflammasome activation in AD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2335 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor protein 1 (NLRP1) | NOD-like receptor (NLR) | Human | hippocampus (neurons) | NA | Q9C000.fasta | Q9C000 | 1473 | protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairment | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2335 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor protein 1 (NLRP1) | NOD-like receptor (NLR) | Human | hippocampus (neurons) | NA | Q9C000.fasta | Q9C000 | 1473 | protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairment | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2336 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor protein 1 (NLRP1) | NOD-like receptor (NLR) | Mice | models of AD | NA | Q2LKU9.fasta | Q2LKU9 | 1182 | protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairment | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2336 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor protein 1 (NLRP1) | NOD-like receptor (NLR) | Mice | models of AD | NA | Q2LKU9.fasta | Q2LKU9 | 1182 | protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairment | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2337 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor protein 1 (NLRP1) | NOD-like receptor (NLR) | Mice | cortical neurons (cell culture, stroke model) | NA | Q2LKU9.fasta | Q2LKU9 | 1182 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2337 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor protein 1 (NLRP1) | NOD-like receptor (NLR) | Mice | cortical neurons (cell culture, stroke model) | NA | Q2LKU9.fasta | Q2LKU9 | 1182 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2338 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor protein 1 (NLRP1) | NOD-like receptor (NLR) | Human | Brain | NA | Q9C000.fasta | Q9C000 | 1473 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2338 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor protein 1 (NLRP1) | NOD-like receptor (NLR) | Human | Brain | NA | Q9C000.fasta | Q9C000 | 1473 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2339 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | cortical neurons (cell culture, stroke model) | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2339 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | cortical neurons (cell culture, stroke model) | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2340 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Brain | NA | Q96P20.fasta | Q96P20 | 1036 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2340 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Brain | NA | Q96P20.fasta | Q96P20 | 1036 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2341 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Rat | primary astrocytes | NA | NA | NA | NA | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | NA |
| PRRID_2341 | MDP (muramyldipeptide) Click for more detail | Gram-negative and Gram-positive bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptide | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Rat | primary astrocytes | NA | NA | NA | NA | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | NA |
| PRRID_2349 | muramyl di- , glycosaminyl muramyl dipeptide Click for more detail | Bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptidoglycan | Synthetic | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 29207344 | 2017 | NA |
| PRRID_2349 | muramyl di- , glycosaminyl muramyl dipeptide Click for more detail | Bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Peptidoglycan | Synthetic | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 29207344 | 2017 | NA |
| PRRID_2350 | muramyl dipeptide (MDP) Click for more detail | Bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | NA | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | NA | Nucleotide-binding oligomerization domain 2, | Q9HC29.fasta | Q9HC29 | 1040 | NA | NA | 29066255 | 2017 | Pubchem_assay |
| PRRID_2350 | muramyl dipeptide (MDP) Click for more detail | Bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | NA | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Human | NA | Nucleotide-binding oligomerization domain 2, | Q9HC29.fasta | Q9HC29 | 1040 | NA | NA | 29066255 | 2017 | Pubchem_assay |
| PRRID_2351 | muramyl dipeptide (MDP) Click for more detail | Bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | NA | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | NA | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | NA | NA | 29038956 | 2017 | Pubchem_assay |
| PRRID_2351 | muramyl dipeptide (MDP) Click for more detail | Bacteria | CC(C(=O)NC(CCC(=O)O)C(=O)N)NC(=O)C(C)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | NA | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | NA | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | NA | NA | 29038956 | 2017 | Pubchem_assay |
| PRRID_2352 | Muropeptides Click for more detail | Gram negative Bacteria (Bacteria) | NA | NA | Peptidoglycan | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 29207344 | 2017 | NA |
| PRRID_2352 | Muropeptides Click for more detail | Gram negative Bacteria (Bacteria) | NA | NA | Peptidoglycan | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 29207344 | 2017 | NA |
| PRRID_2353 | muropeptides with a meso-diaminopimelate residue (meso-DAP) Click for more detail | Gram negative bacteria(Leptospira spp.) | C(CC(C(=O)O)N)CC(C(=O)O)N | NA | NA | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice | NA | NA | Q8BHB0.fasta | Q8BHB0 | 953 | NA | NA | 29038956 | 2017 | Pubchem_assay |
| PRRID_2353 | muropeptides with a meso-diaminopimelate residue (meso-DAP) Click for more detail | Gram negative bacteria(Leptospira spp.) | C(CC(C(=O)O)N)CC(C(=O)O)N | NA | NA | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice | NA | NA | Q8BHB0.fasta | Q8BHB0 | 953 | NA | NA | 29038956 | 2017 | Pubchem_assay |
| PRRID_2361 | N-acetylmuramic acid Click for more detail | Bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Agonist | Synthetic | Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokines | Nod-like receptor C2 (NLRC2) | NOD-like receptor (NLR) | Human | Intracellular | C-terminal leucine-rich regions and NOD domains | NA | NA | NA | triggering production of β-defensins via an NF-κB signaling pathway | NA | 28776416 | 2017 | NA |
| PRRID_2361 | N-acetylmuramic acid Click for more detail | Bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NC(=O)C | NA | Agonist | Synthetic | Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokines | Nod-like receptor C2 (NLRC2) | NOD-like receptor (NLR) | Human | Intracellular | C-terminal leucine-rich regions and NOD domains | NA | NA | NA | triggering production of β-defensins via an NF-κB signaling pathway | NA | 28776416 | 2017 | NA |
| PRRID_2362 | N-acyl glutamyl DAP Click for more detail | NA | NA | NA | Agonist | Synthetic | Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokines | Nod-like receptor C1 (NLRC1) | NOD-like receptor (NLR) | Human | Intracellular | C-terminal leucine-rich regions and NOD domains | NA | NA | NA | triggering production of β-defensins via an NF-κB signaling pathway | NA | 28776416 | 2017 | NA |
| PRRID_2362 | N-acyl glutamyl DAP Click for more detail | NA | NA | NA | Agonist | Synthetic | Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokines | Nod-like receptor C1 (NLRC1) | NOD-like receptor (NLR) | Human | Intracellular | C-terminal leucine-rich regions and NOD domains | NA | NA | NA | triggering production of β-defensins via an NF-κB signaling pathway | NA | 28776416 | 2017 | NA |
| PRRID_2414 | NA Click for more detail | NA | NA | NA | NA | NA | NA | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Human | NA | NLR family CARD domain-containing protein 4, | Q9NPP4.fasta | Q9NPP4 | 1024 | NA | NA | 29066255 | 2017 | Pubchem_assay |
| PRRID_2414 | NA Click for more detail | NA | NA | NA | NA | NA | NA | Nod-like receptor C4 (NLRC4) | NOD-like receptor (NLR) | Human | NA | NLR family CARD domain-containing protein 4, | Q9NPP4.fasta | Q9NPP4 | 1024 | NA | NA | 29066255 | 2017 | Pubchem_assay |
| PRRID_2451 | NA Click for more detail | Human cytomegalovirus (virus) | NA | NA | NA | NA | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | Macrophages | nucleotide-binding oligomerization domain | Q8K3Z0.fasta | Q8K3Z0 | 1020 | Restriction of viral replication | NA | 28823510 | 2017 | Pubchem_assay |
| PRRID_2451 | NA Click for more detail | Human cytomegalovirus (virus) | NA | NA | NA | NA | NA | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | Macrophages | nucleotide-binding oligomerization domain | Q8K3Z0.fasta | Q8K3Z0 | 1020 | Restriction of viral replication | NA | 28823510 | 2017 | Pubchem_assay |
| PRRID_2452 | NA Click for more detail | Human cytomegalovirus (virus) | NA | NA | NA | NA | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice | Macrophages | nucleotide-binding oligomerization domain | Q8BHB0.fasta | Q8BHB0 | 953 | Restriction of viral replication | NA | 28823510 | 2017 | Pubchem_assay |
| PRRID_2452 | NA Click for more detail | Human cytomegalovirus (virus) | NA | NA | NA | NA | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice | Macrophages | nucleotide-binding oligomerization domain | Q8BHB0.fasta | Q8BHB0 | 953 | Restriction of viral replication | NA | 28823510 | 2017 | Pubchem_assay |
| PRRID_2453 | NA Click for more detail | Plasmodium berghei (fungi) | NA | NA | NA | NA | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice | Macrophages | nucleotide-binding oligomerization domain | Q8BHB0.fasta | Q8BHB0 | 953 | Induction of IL-1b, KC, IFNg | NA | 28823510 | 2017 | Pubchem_assay |
| PRRID_2453 | NA Click for more detail | Plasmodium berghei (fungi) | NA | NA | NA | NA | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice | Macrophages | nucleotide-binding oligomerization domain | Q8BHB0.fasta | Q8BHB0 | 953 | Induction of IL-1b, KC, IFNg | NA | 28823510 | 2017 | Pubchem_assay |
| PRRID_2454 | NA Click for more detail | Trypanosoma Cruzi (others) | NA | NA | NA | NA | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice | spleen and heart | nucleotide-binding oligomerization domain | Q8BHB0.fasta | Q8BHB0 | 953 | NOD1-KO mice are highly susceptible to infection | NA | 28823510 | 2017 | Pubchem_assay |
| PRRID_2454 | NA Click for more detail | Trypanosoma Cruzi (others) | NA | NA | NA | NA | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Mice | spleen and heart | nucleotide-binding oligomerization domain | Q8BHB0.fasta | Q8BHB0 | 953 | NOD1-KO mice are highly susceptible to infection | NA | 28823510 | 2017 | Pubchem_assay |
| PRRID_2458 | NA Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | substantia nigra | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2458 | NA Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | substantia nigra | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2499 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Microglia | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | NLRP3 inflammasome activation in AD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2499 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Microglia | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | NLRP3 inflammasome activation in AD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2500 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | cortical neurons (cell culture, stroke model) | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2500 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | cortical neurons (cell culture, stroke model) | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2501 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Brain | NA | Q96P20.fasta | Q96P20 | 1036 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2501 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Brain | NA | Q96P20.fasta | Q96P20 | 1036 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2502 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Rat | primary astrocytes | NA | D4A523.fasta | D4A523 | 1035 | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2502 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Rat | primary astrocytes | NA | D4A523.fasta | D4A523 | 1035 | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2503 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | substantia nigra | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2503 | Nigericin Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | substantia nigra | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2533 | pathogen ssRNA Click for more detail | flu virus, SeV and bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | potassium efflux-NEK7 involved NLRP3 inflammasome complex | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Cytoplasm. Ubiquitously expressed | NA | Q96P20.fasta | Q96P20 | 1036 | ASC-inflammasome- caspase-1-IL-1/IL-18 | NA | 28374903 | 2017 | Pubchem_assay |
| PRRID_2533 | pathogen ssRNA Click for more detail | flu virus, SeV and bacteria | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | potassium efflux-NEK7 involved NLRP3 inflammasome complex | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Cytoplasm. Ubiquitously expressed | NA | Q96P20.fasta | Q96P20 | 1036 | ASC-inflammasome- caspase-1-IL-1/IL-18 | NA | 28374903 | 2017 | Pubchem_assay |
| PRRID_2543 | Peptidoglycan (PGN) Click for more detail | P. gulae (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Causes inflammation and activation of NOD2. | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | HEK cells | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | activate NF-κB. | NA | 28630066 | 2017 | Pubchem_assay |
| PRRID_2543 | Peptidoglycan (PGN) Click for more detail | P. gulae (Bacteria) | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | Peptidoglycan | Natural | Causes inflammation and activation of NOD2. | Nucleotide Binding Oligomerization Domain Containing 2 (Nod2) | NOD-like receptor (NLR) | Mice | HEK cells | NA | Q8K3Z0.fasta | Q8K3Z0 | 1020 | activate NF-κB. | NA | 28630066 | 2017 | Pubchem_assay |
| PRRID_2547 | peptidoglycan (PGN)-derived muropeptides Click for more detail | Bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | NA | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | NA | Nucleotide-binding oligomerization domain 1 | Q9Y239.fasta | Q9Y239 | 953 | NA | NA | 29066255 | 2017 | Pubchem_assay |
| PRRID_2547 | peptidoglycan (PGN)-derived muropeptides Click for more detail | Bacteria | CC(C(=O)O)OC1C(C(OC(C1O)CO)O)N | NA | NA | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | Human | NA | Nucleotide-binding oligomerization domain 1 | Q9Y239.fasta | Q9Y239 | 953 | NA | NA | 29066255 | 2017 | Pubchem_assay |
| PRRID_2551 | PG-derived molecules (iE-DAP and MDP respectively Click for more detail | Bacteria | N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O | NA | Protein | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 28063015 | 2017 | NA |
| PRRID_2551 | PG-derived molecules (iE-DAP and MDP respectively Click for more detail | Bacteria | N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=O | NA | Protein | Natural | NA | Nucleotide Binding Oligomerization Domain Containing 1 (Nod1) | NOD-like receptor (NLR) | NA | NA | NA | NA | NA | NA | NA | NA | 28063015 | 2017 | NA |
| PRRID_2579 | Quil-A Click for more detail | Quillaja sponaria tree (plant) | NA | NA | steroidal or triterpenoid aglycones | Natural | Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokines | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Intracellular | C-terminal leucine-rich regions and NOD domains | Q96P20.fasta | Q96P20 | 1036 | triggering production of β-defensins via an NF-κB signaling pathway | NA | 28776416 | 2017 | Pubchem_assay |
| PRRID_2579 | Quil-A Click for more detail | Quillaja sponaria tree (plant) | NA | NA | steroidal or triterpenoid aglycones | Natural | Agonist recognition triggers receptor oligomerization and recruitment of signaling molecules that drive NF-κB-mediated expression of inflammatory cytokines | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Intracellular | C-terminal leucine-rich regions and NOD domains | Q96P20.fasta | Q96P20 | 1036 | triggering production of β-defensins via an NF-κB signaling pathway | NA | 28776416 | 2017 | Pubchem_assay |
| PRRID_2595 | ROS Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Microglia | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | NLRP3 inflammasome activation in AD models | NA | 28805121 | 2017 | Pubchem_assay |
| PRRID_2595 | ROS Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | Microglia | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | NLRP3 inflammasome activation in AD models | NA | 28805121 | 2017 | Pubchem_assay |
| PRRID_2596 | ROS Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | cortical neurons (cell culture, stroke model) | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2596 | ROS Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Mice | cortical neurons (cell culture, stroke model) | NA | Q8R4B8.fasta | Q8R4B8 | 1033 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2597 | ROS Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Brain | NA | Q96P20.fasta | Q96P20 | 1036 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2597 | ROS Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Human | Brain | NA | Q96P20.fasta | Q96P20 | 1036 | protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2598 | ROS Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Rat | primary astrocytes | NA | D4A523.fasta | D4A523 | 1035 | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | Pubchem_assay |
| PRRID_2598 | ROS Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | NA | Nod-like receptor P3 (NLRP3) | NOD-like receptor (NLR) | Rat | primary astrocytes | NA | D4A523.fasta | D4A523 | 1035 | protein ‚Üë, activation of NLRP3 inflammasome in PD models | NA | 28801521 | 2017 | Pubchem_assay |