Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0008Candida albicans

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Candida albicans(fungi)NANAWhole cellNaturalCandida albicans binds with human macrophage mannose receptor via carbohydrate recognition-like domains.Mannose receptorMannose receptor (MR)HumanMacrophagesCRDsP22897.fastaP228971456It leads to the receptor-mediated endorytosis of mannose-rich glycoconjugate as well as phagocytosis as well as pinocytisisof yeasts.Phagocytosis assay22587071990Pubchem Assay
PRRID_0008Candida albicans

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Candida albicans(fungi)NANAWhole cellNaturalCandida albicans binds with human macrophage mannose receptor via carbohydrate recognition-like domains.Mannose receptorMannose receptor (MR)HumanMacrophagesCRDsP22897.fastaP228971456It leads to the receptor-mediated endorytosis of mannose-rich glycoconjugate as well as phagocytosis as well as pinocytisisof yeasts.Phagocytosis assay22587071990Pubchem Assay
PRRID_0135Mannan

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalStimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMonocytesNAO00206.fastaO00206839This is responsible for the anti-fungal response of the host immune system.ELISA122229392002Pubchem Assay
PRRID_0135Mannan

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalStimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMonocytesNAO00206.fastaO00206839This is responsible for the anti-fungal response of the host immune system.ELISA122229392002Pubchem Assay
PRRID_0137Mannan

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalStimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMonocytesNAO00206.fastaO00206839This is responsible for the anti-fungal response of the host immune system.ELISA122229392002Pubchem Assay
PRRID_0137Mannan

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalStimulation with mannan leads to the induction of TNF-alpha, which leads to the ptoduction of the proinflammatory cytokines.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanMonocytesNAO00206.fastaO00206839This is responsible for the anti-fungal response of the host immune system.ELISA122229392002Pubchem Assay
PRRID_0194Conidia

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Aspergillus fumigatus(fungi)NANASporeNaturalIt exhibited phenotypic characteristics of mature DC, with increased CD86 and induced CD83 expression. It also exhibited the higher level og IL-10.DC-SIGNC type Lectin (CTL/CLR)HumanMacrophages and Dendritic cellsNANANANAIt mediates binding and internalization of Aspergillus fumigatus conidia.ELISA154945142004NA
PRRID_0194Conidia

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Aspergillus fumigatus(fungi)NANASporeNaturalIt exhibited phenotypic characteristics of mature DC, with increased CD86 and induced CD83 expression. It also exhibited the higher level og IL-10.DC-SIGNC type Lectin (CTL/CLR)HumanMacrophages and Dendritic cellsNANANANAIt mediates binding and internalization of Aspergillus fumigatus conidia.ELISA154945142004NA
PRRID_0198glucuronoxylomannan

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Cryptococcus neoformans(fungi)NANACarbohydrateNaturalIt leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceLungNAQ9QUK6.fastaQ9QUK6835It leads to the inflammatory response against the fungi Cryptococcus neoformans.ELISA153220352004Pubchem Assay
PRRID_0198glucuronoxylomannan

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Cryptococcus neoformans(fungi)NANACarbohydrateNaturalIt leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon.Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)MiceLungNAQ9QUK6.fastaQ9QUK6835It leads to the inflammatory response against the fungi Cryptococcus neoformans.ELISA153220352004Pubchem Assay
PRRID_0199glucuronoxylomannan

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Cryptococcus neoformans(fungi)NANACarbohydrateNaturalIt leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLungNAQ9QUN7.fastaQ9QUN7784It leads to the inflammatory response against the fungi Cryptococcus neoformans.ELISA153220352004Pubchem Assay
PRRID_0199glucuronoxylomannan

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Cryptococcus neoformans(fungi)NANACarbohydrateNaturalIt leads to the induction of tumor necrosis factor alpha, interleukin-4, IL-10, IL-12p70 and gamma interferon.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)MiceLungNAQ9QUN7.fastaQ9QUN7784It leads to the inflammatory response against the fungi Cryptococcus neoformans.ELISA153220352004Pubchem Assay
PRRID_0273Carbohydrate moieties

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Candida albicans(fungi)NANACarbohydrateNaturalThe stimulation of mincle by carbohydrate moities, leads to the production of TNF-‚ç∫ by macrophages.MincleC type Lectin (CTL/CLR)MiceMacropahgesCarbohydrate binding motif (EPN)Q9R0Q8.fastaQ9R0Q8214Mincle plays a significant role in the mammalian immune response against the yeast.ELISA184907402008Pubchem Assay
PRRID_0273Carbohydrate moieties

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Candida albicans(fungi)NANACarbohydrateNaturalThe stimulation of mincle by carbohydrate moities, leads to the production of TNF-‚ç∫ by macrophages.MincleC type Lectin (CTL/CLR)MiceMacropahgesCarbohydrate binding motif (EPN)Q9R0Q8.fastaQ9R0Q8214Mincle plays a significant role in the mammalian immune response against the yeast.ELISA184907402008Pubchem Assay
PRRID_0292Glucan

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eukaryotic fungi (fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalGlucan binds to vitellogenin with high affinity.VitellogeninPhospholipoglycoproteinHexagrammos otakiiMacropahesNANANANAVg is involved in anti-infectious response, functions as an opsonin that can enhance macrophage phagocytosis.ELISA183984662008NA
PRRID_0292Glucan

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eukaryotic fungi (fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalGlucan binds to vitellogenin with high affinity.VitellogeninPhospholipoglycoproteinHexagrammos otakiiMacropahesNANANANAVg is involved in anti-infectious response, functions as an opsonin that can enhance macrophage phagocytosis.ELISA183984662008NA
PRRID_0359Candida albicans

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Candida albicans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.C03F11.3Transmembrane ProteinCaenorhabditis elegansNANANANANAIt provides the antifungal immunity and host defense by mediating yeast binding and subsequent macrophage activation.NA192376022009NA
PRRID_0359Candida albicans

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Candida albicans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.C03F11.3Transmembrane ProteinCaenorhabditis elegansNANANANANAIt provides the antifungal immunity and host defense by mediating yeast binding and subsequent macrophage activation.NA192376022009NA
PRRID_0360Candida albicans

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Candida albicans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)MiceMacropahgesNAQ08857.fastaQ08857472It provides the antifungal immunity and host defense by mediating yeast binding and subsequent macrophage activation.NA192376022009Pubchem Assay
PRRID_0360Candida albicans

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Candida albicans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)MiceMacropahgesNAQ08857.fastaQ08857472It provides the antifungal immunity and host defense by mediating yeast binding and subsequent macrophage activation.NA192376022009Pubchem Assay
PRRID_0363Cryptococcus neoformans

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Cryptococcus neoformans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.CED-1Transmembrane ProteinCaenorhabditis elegansNANANANANAIt provides the antifungal immunity and host defense by mediating yeast binding and subsequent macrophage activation.NA192376022009NA
PRRID_0363Cryptococcus neoformans

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Cryptococcus neoformans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.CED-1Transmembrane ProteinCaenorhabditis elegansNANANANANAIt provides the antifungal immunity and host defense by mediating yeast binding and subsequent macrophage activation.NA192376022009NA
PRRID_0364Cryptococcus neoformans

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Cryptococcus neoformans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.SCARF1Scavenger receptor (SR)MiceMacropahgesNAQ68EF1.fastaQ68EF1474Macrophages phagocytose and kill C. neoformans and binding of these fungi to endothelial cells initiates tissue invasion.NA192376022009Pubchem Assay
PRRID_0364Cryptococcus neoformans

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Cryptococcus neoformans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.SCARF1Scavenger receptor (SR)MiceMacropahgesNAQ68EF1.fastaQ68EF1474Macrophages phagocytose and kill C. neoformans and binding of these fungi to endothelial cells initiates tissue invasion.NA192376022009Pubchem Assay
PRRID_0365Cryptococcus neoformans

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Cryptococcus neoformans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)MiceMacropahgesNAQ08857.fastaQ08857472It provides the antifungal immunity and host defense by mediating yeast binding and subsequent macrophage activation.NA192376022009Pubchem Assay
PRRID_0365Cryptococcus neoformans

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Cryptococcus neoformans(fungi)NANAWhole organismNaturalIt inducs the production of IL-1beta , TNF, IL-12 p40 , IFN- gamma, MIP-2, MIP-1 alpha , MIP-1 beta, RANTES, and IP-10.cluster of differentiation 36 (CD36)Pattern recognition receptor (PRR)MiceMacropahgesNAQ08857.fastaQ08857472It provides the antifungal immunity and host defense by mediating yeast binding and subsequent macrophage activation.NA192376022009Pubchem Assay
PRRID_04011,3 beta glucan

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Sparassis crispa (fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalAnti-tumour propertiesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micedendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It can induce the phenotypic and functional maturation of DCs.NA206991312010Pubchem Assay
PRRID_04011,3 beta glucan

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Sparassis crispa (fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalAnti-tumour propertiesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micedendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835It can induce the phenotypic and functional maturation of DCs.NA206991312010Pubchem Assay
PRRID_0468DNA

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Cordyceps sinensis(fungi)TAGAGGAAGTAAAAGTCGTAATAAGGTCTCCGTTAGTAAACTAGCGGAGGGATTATTATCGAGTTACCACTCCTAAACCCCCTGCGAATACTACAGCAGTTGCCTCGGCGGGACCGCCCCGGCGCCCTAGGGCCCGGACTAGGGCGCCCGCCGGAGGACCCTTAGACCCTCCTATTGTAGTAGCATCTCTTAATTAAGAAGCAAGCAAATAAATTAAAACTTTTAATAACGGATCTCTTAGTTTTAGCATTAATAAAGAACGCAGCGAAATACGATAAGTAATGTAAATTGTAGAATTTAGTAAACTATCGAATCTTTAAACGTATATTACGCCGCTAGCACTCTAGCGGGCATGCCTGTCCGAGCGTTACCTTAACCCTTAAGCCCCCCGCCTCGCGGCGGCGGGGCCCGGCCTTAGGGGTCACGGCCCCACGCCGCCCCCTAAACGCAGTAGCGACCCCGCCGCGGCTCCCCTACGCAATAGCTTACTAAGTACCTCGCACTAGGAGCGCGGAGGCGGTCACGCCGTAAAACCACTATACCCTCTAGTTAACCTCGGATTAGGTAGGGATACCCGCTAAACTTAAGCATATTAATAAGCGGAGGAAAAGAAACTAATAGGGATTGCCCTAGTAACGGCGAGTAAAGCGGCAATAGCTTAAATTTGAAATCTAGCCCCCCCGCG685Nucleic AcidNaturalUpon stimulation with C. sinensis DNA, BM-DCs released IL-12p40 and TNF-a and expressed CD40.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceBone marrow-derived dendritic cells (BM-DCs).Leucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It exhibits immunomodulating activity against Cordyceps sinensisLuciferase assay204519012010Pubchem Assay
PRRID_0468DNA

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Cordyceps sinensis(fungi)TAGAGGAAGTAAAAGTCGTAATAAGGTCTCCGTTAGTAAACTAGCGGAGGGATTATTATCGAGTTACCACTCCTAAACCCCCTGCGAATACTACAGCAGTTGCCTCGGCGGGACCGCCCCGGCGCCCTAGGGCCCGGACTAGGGCGCCCGCCGGAGGACCCTTAGACCCTCCTATTGTAGTAGCATCTCTTAATTAAGAAGCAAGCAAATAAATTAAAACTTTTAATAACGGATCTCTTAGTTTTAGCATTAATAAAGAACGCAGCGAAATACGATAAGTAATGTAAATTGTAGAATTTAGTAAACTATCGAATCTTTAAACGTATATTACGCCGCTAGCACTCTAGCGGGCATGCCTGTCCGAGCGTTACCTTAACCCTTAAGCCCCCCGCCTCGCGGCGGCGGGGCCCGGCCTTAGGGGTCACGGCCCCACGCCGCCCCCTAAACGCAGTAGCGACCCCGCCGCGGCTCCCCTACGCAATAGCTTACTAAGTACCTCGCACTAGGAGCGCGGAGGCGGTCACGCCGTAAAACCACTATACCCTCTAGTTAACCTCGGATTAGGTAGGGATACCCGCTAAACTTAAGCATATTAATAAGCGGAGGAAAAGAAACTAATAGGGATTGCCCTAGTAACGGCGAGTAAAGCGGCAATAGCTTAAATTTGAAATCTAGCCCCCCCGCG685Nucleic AcidNaturalUpon stimulation with C. sinensis DNA, BM-DCs released IL-12p40 and TNF-a and expressed CD40.Toll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceBone marrow-derived dendritic cells (BM-DCs).Leucine-rich Repeat (LRR) DomainQ9NR96.fastaQ9NR961032It exhibits immunomodulating activity against Cordyceps sinensisLuciferase assay204519012010Pubchem Assay
PRRID_0602lentinan

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Lentinus edodes (fungi)C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)O)OC5C(C(C(C(O5)COC6C(C(C(C(O6)CO)O)O)O)O)OC7C(C(C(C(O7)CO)O)O)O)O)O)O)O)O)O)O)ONABiological response modifiers (BRMs)NaturalMedicinal propertiesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micedendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835used clinically for cancer therapyNA206991312010Pubchem Assay
PRRID_0602lentinan

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Lentinus edodes (fungi)C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)O)O)OC3C(C(C(C(O3)CO)O)OC4C(C(C(C(O4)CO)O)OC5C(C(C(C(O5)COC6C(C(C(C(O6)CO)O)O)O)O)OC7C(C(C(C(O7)CO)O)O)O)O)O)O)O)O)O)O)ONABiological response modifiers (BRMs)NaturalMedicinal propertiesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micedendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835used clinically for cancer therapyNA206991312010Pubchem Assay
PRRID_0645Lipopolysaccharide (LPS)

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Aspergillus fumigatus(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt induces the secretion of IL-6, IL-8, CC chemokine-ligand 20 (CCL20) and thymosin β4 (Tβ4).Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanTelomerase-Immortalized Human Stroma Fibroblasts (THSFs)NAO00206.fastaO00206839It has the immunostimulatory role.ELISA203050392010Pubchem Assay
PRRID_0645Lipopolysaccharide (LPS)

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Aspergillus fumigatus(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalIt induces the secretion of IL-6, IL-8, CC chemokine-ligand 20 (CCL20) and thymosin β4 (Tβ4).Toll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanTelomerase-Immortalized Human Stroma Fibroblasts (THSFs)NAO00206.fastaO00206839It has the immunostimulatory role.ELISA203050392010Pubchem Assay
PRRID_0668Lipopolysaccharide (LPS)

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Bacteria and fungiCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS and β-glucan binds to the LGBP and induce innate immunityLipopolysaccharide and b-1, 3-glucan binding protein (LGBP)Pattern recognition receptor (PRR)Drosophila melanogasterNANANANANAIt helps in pathogen recognition, activation of proPO system, induction of antimicrobial peptideNA206595622010NA
PRRID_0668Lipopolysaccharide (LPS)

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Bacteria and fungiCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalLPS and β-glucan binds to the LGBP and induce innate immunityLipopolysaccharide and b-1, 3-glucan binding protein (LGBP)Pattern recognition receptor (PRR)Drosophila melanogasterNANANANANAIt helps in pathogen recognition, activation of proPO system, induction of antimicrobial peptideNA206595622010NA
PRRID_0671Mannan

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)dendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA207131002010Pubchem Assay
PRRID_0671Mannan

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Mice (Murine)dendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835NANA207131002010Pubchem Assay
PRRID_0672Mannan

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0672Mannan

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,TIRAP, TRAM and TRIFToll-like receptor 4 (TLR4)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO00206.fastaO00206839It leadsto the secretion of the proinfalmmatory cytokines and IFN-βNA206201292010Pubchem Assay
PRRID_0749Phospholipomannan

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Candida albicans(fungi)NANACarbohydrateNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0749Phospholipomannan

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Candida albicans(fungi)NANACarbohydrateNaturalUpon recogniton by the TLR, it induces induces the recruitment of adaptor proteins MyD88,/TIRAP and aloow the rerutiment of downstream effectorToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanCell surfaceLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784It leadsto the secretion of the proinfalmmatory cytokinesNA206201292010Pubchem Assay
PRRID_0779PS-G

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Ganoderma lucidum (fungi)NANACarbohydrateNaturalBinding resulted into the activation of NF-Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)Mice (Murine)bone derived dendritic cellsLeucine-rich Repeat (LRR) DomainQ9JLF7.fastaQ9JLF7859promote the activation and maturation of BMDCs and macrophagesNA206738832010Pubchem Assay
PRRID_0779PS-G

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Ganoderma lucidum (fungi)NANACarbohydrateNaturalBinding resulted into the activation of NF-Toll-like receptor 5 (TLR5)Toll-like receptor (TLR)Mice (Murine)bone derived dendritic cellsLeucine-rich Repeat (LRR) DomainQ9JLF7.fastaQ9JLF7859promote the activation and maturation of BMDCs and macrophagesNA206738832010Pubchem Assay
PRRID_0805sonifilan

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Schizophyllum commune (fungi)C(C1C(C(C(C(O1)O)O)OC2C(C(C(C(O2)COC3C(C(C(C(O3)CO)O)O)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O)ONABiological response modifiers (BRMs)NaturalMedicinal propertiesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micedendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835used clinically for cancer therapyNA206991312010Pubchem Assay
PRRID_0805sonifilan

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Schizophyllum commune (fungi)C(C1C(C(C(C(O1)O)O)OC2C(C(C(C(O2)COC3C(C(C(C(O3)CO)O)O)O)O)OC4C(C(C(C(O4)CO)O)O)O)O)O)ONABiological response modifiers (BRMs)NaturalMedicinal propertiesToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Micedendritic cells and macrophagesLeucine-rich Repeat (LRR) DomainQ9QUK6.fastaQ9QUK6835used clinically for cancer therapyNA206991312010Pubchem Assay
PRRID_0861β -1,3-glucan

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P. pastoris (fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalβ-glucan binds to the LGBP and induce innate immunityLipopolysaccharide and b-1, 3-glucan binding protein (LGBP)Pattern recognition receptor (PRR)Chlamys farreriHemocytes, gills and mantleNANANANAIt is involved in pathogen recognition and it's clearanceNA206595622010NA
PRRID_0861β -1,3-glucan

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P. pastoris (fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalβ-glucan binds to the LGBP and induce innate immunityLipopolysaccharide and b-1, 3-glucan binding protein (LGBP)Pattern recognition receptor (PRR)Chlamys farreriHemocytes, gills and mantleNANANANAIt is involved in pathogen recognition and it's clearanceNA206595622010NA
PRRID_0862β -1,3-glucan

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Candida albicans(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalNAGmCP10Pattern recognition receptor (PRR)Galleria mellonellahemolymphNANANANAIt has opsonin activity for the phagocytosis of the microorganisms by hemocytes.NA205195172010NA
PRRID_0862β -1,3-glucan

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Candida albicans(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalNAGmCP10Pattern recognition receptor (PRR)Galleria mellonellahemolymphNANANANAIt has opsonin activity for the phagocytosis of the microorganisms by hemocytes.NA205195172010NA
PRRID_1023b-1,3-glucans.

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Bacteria and fungiC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONANANaturalNAPibGRPGastrin-releasing peptide receptor (GRP)Plodia interpunctellahemolymphNANANANAactivation of the proPO pathwayCurdlan Pull-down Assay232374932013NA
PRRID_1023b-1,3-glucans.

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Bacteria and fungiC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONANANaturalNAPibGRPGastrin-releasing peptide receptor (GRP)Plodia interpunctellahemolymphNANANANAactivation of the proPO pathwayCurdlan Pull-down Assay232374932013NA
PRRID_1726DIP

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 D. indusiata(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NARAW264.7 cellsNANANANA up-regulation of nitric oxide (NO), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor (TNF-α) production as well as the mRNA expression levels of iNOS, IL-1β, IL-6 and TNF-α in macrophages.Flow cytometry and confocal laser-scanning microscopy analyses272930362016NA
PRRID_1726DIP

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 D. indusiata(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NARAW264.7 cellsNANANANA up-regulation of nitric oxide (NO), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumour necrosis factor (TNF-α) production as well as the mRNA expression levels of iNOS, IL-1β, IL-6 and TNF-α in macrophages.Flow cytometry and confocal laser-scanning microscopy analyses272930362016NA
PRRID_1744Galactomannan

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Aspergillus fumigatus(fungi)C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)O)O)O)OC3C(C(C(C(O3)CO)O)O)O)O)O)O)ONANANaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANADownregulates the IL-6 and TNF- productionNA267757992016NA
PRRID_1744Galactomannan

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Aspergillus fumigatus(fungi)C(C1C(C(C(C(O1)OCC2C(C(C(C(O2)O)O)O)OC3C(C(C(C(O3)CO)O)O)O)O)O)O)ONANANaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANADownregulates the IL-6 and TNF- productionNA267757992016NA
PRRID_1786Lipopolysaccharide (LPS)

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Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBacterial infection and immunostimulantCgPGRPS2Peptidoglycan Recognition Receptor (PGRPs)Crassostrea gigasCytoplasmone typical PGRP/amidase domainNANANAActivate NF-kBPAMPs binding assay280420812016NA
PRRID_1786Lipopolysaccharide (LPS)

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Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalBacterial infection and immunostimulantCgPGRPS2Peptidoglycan Recognition Receptor (PGRPs)Crassostrea gigasCytoplasmone typical PGRP/amidase domainNANANAActivate NF-kBPAMPs binding assay280420812016NA
PRRID_1787Peptidoglycan (PGN)

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Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalBacterial infection and immunostimulantCgPGRPS2Peptidoglycan Recognition Receptor (PGRPs)Crassostrea gigasCytoplasmone typical PGRP/amidase domainNANANAActivate NF-kBPAMPs binding assay280420812016NA
PRRID_1787Peptidoglycan (PGN)

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Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalBacterial infection and immunostimulantCgPGRPS2Peptidoglycan Recognition Receptor (PGRPs)Crassostrea gigasCytoplasmone typical PGRP/amidase domainNANANAActivate NF-kBPAMPs binding assay280420812016NA
PRRID_1788Mannan

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Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalBacterial infection and immunostimulantCgPGRPS2Peptidoglycan Recognition Receptor (PGRPs)Crassostrea gigasCytoplasmone typical PGRP/amidase domainNANANAActivate NF-kBPAMPs binding assay280420812016NA
PRRID_1788Mannan

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Gram positive bacteria, Staphylococcus aureus and fungi Yarrowia lipolytica (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalBacterial infection and immunostimulantCgPGRPS2Peptidoglycan Recognition Receptor (PGRPs)Crassostrea gigasCytoplasmone typical PGRP/amidase domainNANANAActivate NF-kBPAMPs binding assay280420812016NA
PRRID_1888β­glucan

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pathogenic fungiC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlycoproteinNaturalFungal infectionDectin-1C type Lectin (CTL/CLR)NAmacrophages, den- dritic cells, neutrophils, and a subset of T and B cellscarbohydrate domainNANANAphagocytosis of fungiNA272884072016NA
PRRID_1888β­glucan

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pathogenic fungiC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlycoproteinNaturalFungal infectionDectin-1C type Lectin (CTL/CLR)NAmacrophages, den- dritic cells, neutrophils, and a subset of T and B cellscarbohydrate domainNANANAphagocytosis of fungiNA272884072016NA
PRRID_18901,3 beta glucan

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Candida albicans(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_18901,3 beta glucan

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Candida albicans(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_18911,3 beta glucan

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Candida albicans(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247protective role in infection modelNA281676512017Pubchem_assay
PRRID_18911,3 beta glucan

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Candida albicans(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONACarbohydrateNaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247protective role in infection modelNA281676512017Pubchem_assay
PRRID_1910alpha-mannans

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNANANaturalNACLEC6A (Dectin-2)C type Lectin (CTL/CLR)HumanNAC-Type Lectin Domain Family 4, Member MQ6EIG7.fastaQ6EIG7209NANA290662552017Pubchem_assay
PRRID_1910alpha-mannans

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Candida albicans(fungi)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNANANaturalNACLEC6A (Dectin-2)C type Lectin (CTL/CLR)HumanNAC-Type Lectin Domain Family 4, Member MQ6EIG7.fastaQ6EIG7209NANA290662552017Pubchem_assay
PRRID_1946b-1,3-glucans.

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Candida glabrata(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalBinding and activation of Dectin -1Dectin-1C type Lectin (CTL/CLR)MiceMacrophagesNAQ9BXN2.fastaQ9BXN2247activation of the NF-κB and MAPK pathwaysBinding assay286585922017Pubchem_assay
PRRID_1946b-1,3-glucans.

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Candida glabrata(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalBinding and activation of Dectin -1Dectin-1C type Lectin (CTL/CLR)MiceMacrophagesNAQ9BXN2.fastaQ9BXN2247activation of the NF-κB and MAPK pathwaysBinding assay286585922017Pubchem_assay
PRRID_1954Beta glucans

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Candida albicans(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlucanNaturalActivation of CLEC7ACLEC7AC type Lectin (CTL/CLR)HumanNANAQ9BXN2.fastaQ9BXN2247critical functions in host defense against Candida albicans invasionNA288241662017Pubchem_assay
PRRID_1954Beta glucans

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Candida albicans(fungi)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlucanNaturalActivation of CLEC7ACLEC7AC type Lectin (CTL/CLR)HumanNANAQ9BXN2.fastaQ9BXN2247critical functions in host defense against Candida albicans invasionNA288241662017Pubchem_assay
PRRID_1972Chitin

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V.dahliae (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalActivate PTI( PAMP triggered immunity )Lyp1Pattern recognition receptor (PRR)CottonPlasma memebraneLysin motif (LysM) domainNANANAactivate downstream defense processes, and enhance resistance to V. dahliae.NA288701722017NA
PRRID_1972Chitin

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V.dahliae (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalActivate PTI( PAMP triggered immunity )Lyp1Pattern recognition receptor (PRR)CottonPlasma memebraneLysin motif (LysM) domainNANANAactivate downstream defense processes, and enhance resistance to V. dahliae.NA288701722017NA
PRRID_1973Chitin

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V.dahliae (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalActivate PTI( PAMP triggered immunity )Lyk7LysMCottonPlasma memebraneLysin motif (LysM) domainNANANAactivate downstream defense processes, and enhance resistance to V. dahliae.NA288701722017NA
PRRID_1973Chitin

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V.dahliae (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalActivate PTI( PAMP triggered immunity )Lyk7LysMCottonPlasma memebraneLysin motif (LysM) domainNANANAactivate downstream defense processes, and enhance resistance to V. dahliae.NA288701722017NA
PRRID_1974Chitin

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V.dahliae (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalActivate PTI( PAMP triggered immunity )LysMe3Pattern recognition receptor (PRR)CottonPlasma memebraneLysin motif (LysM) domainNANANAactivate downstream defense processes, and enhance resistance to V. dahliae.NA288701722017NA
PRRID_1974Chitin

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V.dahliae (fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalActivate PTI( PAMP triggered immunity )LysMe3Pattern recognition receptor (PRR)CottonPlasma memebraneLysin motif (LysM) domainNANANAactivate downstream defense processes, and enhance resistance to V. dahliae.NA288701722017NA
PRRID_1975Chitin

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protozoa, fungi, arthropods, and nematodes (others)NANAPattern-associated molecular patterns (PAMPs)NaturalChitin induces cy- tokine production, leukocyte recruitment, and alternative mac- rophage activationToll-like receptor 2 (TLR2)Toll-like receptor (TLR) HumanLungs and gutTIR domainO60603.fastaO60603784Activate immune cells to induce cytokine productionNA282515812017Pubchem_assay
PRRID_1975Chitin

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protozoa, fungi, arthropods, and nematodes (others)NANAPattern-associated molecular patterns (PAMPs)NaturalChitin induces cy- tokine production, leukocyte recruitment, and alternative mac- rophage activationToll-like receptor 2 (TLR2)Toll-like receptor (TLR) HumanLungs and gutTIR domainO60603.fastaO60603784Activate immune cells to induce cytokine productionNA282515812017Pubchem_assay
PRRID_1976Chitin

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protozoa, fungi, arthropods, and nematodes (others)NANAPattern-associated molecular patterns (PAMPs)NaturalChitin induces cy- tokine production, leukocyte recruitment, and alternative mac- rophage activationDectin-1C type Lectin (CTL/CLR) HumanLungs and gutNANANANAActivate immune cells to induce cytokine productionNA282515812017NA
PRRID_1976Chitin

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protozoa, fungi, arthropods, and nematodes (others)NANAPattern-associated molecular patterns (PAMPs)NaturalChitin induces cy- tokine production, leukocyte recruitment, and alternative mac- rophage activationDectin-1C type Lectin (CTL/CLR) HumanLungs and gutNANANANAActivate immune cells to induce cytokine productionNA282515812017NA
PRRID_2060Fungal chitin

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Verticillium spp (fungi)NANANANaturalNAGh-LYK1LysMCottonMembrane boundLysM (Lysine-Motif)NANANANACLCrV-based VIGS methods293267412017NA
PRRID_2060Fungal chitin

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Verticillium spp (fungi)NANANANaturalNAGh-LYK1LysMCottonMembrane boundLysM (Lysine-Motif)NANANANACLCrV-based VIGS methods293267412017NA
PRRID_2061Fungal chitin

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Verticillium spp (fungi)NANANANaturalNAGh-LYK2LysMCottonMembrane boundLysM (Lysine-Motif)NANANANACLCrV-based VIGS methods293267412017NA
PRRID_2061Fungal chitin

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Verticillium spp (fungi)NANANANaturalNAGh-LYK2LysMCottonMembrane boundLysM (Lysine-Motif)NANANANACLCrV-based VIGS methods293267412017NA
PRRID_2071Germ tubes

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_2071Germ tubes

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_2072Germ tubes

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2072Germ tubes

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2330Maturing conidia

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_2330Maturing conidia

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRMiceNANAQ6QLQ4.fastaQ6QLQ4244protective role in infection modelNA281676512017Pubchem_assay
PRRID_2331Maturing conidia

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2331Maturing conidia

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Aspergillus fumigatus(fungi)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-1 (Clec7a)Syk-coupled CLRHumanNANAQ9BXN2.fastaQ9BXN2247Protective role in infection modelNA281676512017Pubchem_assay
PRRID_2423NA

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pathogenic viruses, bacteria, and fungiNANANANaturalNAMRC1Mannose receptor (MR)HumanNANAP22897.fastaP228971456NANA290662552017Pubchem_assay
PRRID_2423NA

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pathogenic viruses, bacteria, and fungiNANANANaturalNAMRC1Mannose receptor (MR)HumanNANAP22897.fastaP228971456NANA290662552017Pubchem_assay
PRRID_2424NA

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Gram-positive bacteria and fungiNANANANaturalNAToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanNANAQ9Y2C9.fastaQ9Y2C9796NANA290662552017Pubchem_assay
PRRID_2424NA

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Gram-positive bacteria and fungiNANANANaturalNAToll-like receptor 6 (TLR6)Toll-like receptor (TLR)HumanNANAQ9Y2C9.fastaQ9Y2C9796NANA290662552017Pubchem_assay