Browse result page of PRRDB 2.0
| PRRID | Name of Ligand | Source of ligand | Sequence of Ligand | Length of Ligand | Type of Ligand | Occurence | Role of Ligand | Name of Receptor | Type of Reeptor | Source of the Receptor | Localization | Domain | Sequence of Receptor | Swiss prot ID | Length of receptor | Function of Receptor | Assay used | PMID | Year of publication | Pubchem assay |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| PRRID_1178 | 9-benzyl- 105 8-hydroxy-2-(2-methoxyethoxy)adenine Click for more detail | NA | COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3 | NA | Nucleic Acid | Synthetic | stimulates TLR7 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice (Murine) | pDCs | intracellular receptors | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA | 24814238 | 2014 | Pubchem_assay |
| PRRID_1178 | 9-benzyl- 105 8-hydroxy-2-(2-methoxyethoxy)adenine Click for more detail | NA | COCCOC1=NC2=C(C(=N1)N)NC(=O)N2CC3=CC=CC=C3 | NA | Nucleic Acid | Synthetic | stimulates TLR7 | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice (Murine) | pDCs | intracellular receptors | P58681.fasta | P58681 | 1050 | important role in the immune response to viral infection | flow cytometry analysis, Immunofluorescence, Quantitative polymerase chain reaction (qPCR), enzyme-linked immunosorbent assay (ELISA | 24814238 | 2014 | Pubchem_assay |
| PRRID_1180 | amidation of the mesoDAP Click for more detail | PGN of Gram-positive bacteria | C(CC(C(=O)O)N)CC(C(=O)O)N | NA | Protein | Natural | activates NOD2 but not recognised by NOD2 | Nod-like receptor protein 3 (P2X7R) (NLRP3 (P2X7R) | NOD-like receptor (NLR) | Mice | most adult tissues | intracellular receptors | Q8BHB0.fasta | Q8BHB0 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 24779390 | 2014 | Pubchem_assay |
| PRRID_1180 | amidation of the mesoDAP Click for more detail | PGN of Gram-positive bacteria | C(CC(C(=O)O)N)CC(C(=O)O)N | NA | Protein | Natural | activates NOD2 but not recognised by NOD2 | Nod-like receptor protein 3 (P2X7R) (NLRP3 (P2X7R) | NOD-like receptor (NLR) | Mice | most adult tissues | intracellular receptors | Q8BHB0.fasta | Q8BHB0 | 953 | play key roles in regulation of innate immune response. NLRs can cooperate with Toll-like receptors and regulate inflammatory and apoptotic response. | NA | 24779390 | 2014 | Pubchem_assay |
| PRRID_1187 | Bacterial lipoprotein Click for more detail | Francisella novicida (Bacteria) | MKYGNLMMTKKKLLIGMVTISGIVILGSCGKTETVNELLIVDQCNDVRDLCRLELANAQVSRYTNFLGKTIKRLQSQTPLRDIQGTVTWNASAGTSLADNSDVQSELGLSCQDDNCTANSNSTAYTLPVGSNTISVSGTVTVDGKTIDLATDVPALVINTSAAGSSVHVFPTELEGNLTLQDLVDSLNQGRHYAHATFSADGSNLKIQCDPGYVWLDDINPEYGGQSSAASARSVAMVSWVEELEEFRVDEFRFLHFDMSSLTLNGVRLGNHVFWEMGCWPT | 282 | Fatty acid | Natural | elicit innate immune response | RIP2 | Pattern recognition receptor (PRR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24772391 | 2014 | Pubchem_assay |
| PRRID_1187 | Bacterial lipoprotein Click for more detail | Francisella novicida (Bacteria) | MKYGNLMMTKKKLLIGMVTISGIVILGSCGKTETVNELLIVDQCNDVRDLCRLELANAQVSRYTNFLGKTIKRLQSQTPLRDIQGTVTWNASAGTSLADNSDVQSELGLSCQDDNCTANSNSTAYTLPVGSNTISVSGTVTVDGKTIDLATDVPALVINTSAAGSSVHVFPTELEGNLTLQDLVDSLNQGRHYAHATFSADGSNLKIQCDPGYVWLDDINPEYGGQSSAASARSVAMVSWVEELEEFRVDEFRFLHFDMSSLTLNGVRLGNHVFWEMGCWPT | 282 | Fatty acid | Natural | elicit innate immune response | RIP2 | Pattern recognition receptor (PRR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24772391 | 2014 | Pubchem_assay |
| PRRID_1189 | beta-defensin Click for more detail | Host (Endogenous) (others) | MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS | 69 | Peptide | Natural | Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses | JNKBP1 | Pattern recognition receptor (PRR) | TLR-deficient Mice on a C57BL/6 | monocyte/macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24801735 | 2014 | Pubchem_assay |
| PRRID_1189 | beta-defensin Click for more detail | Host (Endogenous) (others) | MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS | 69 | Peptide | Natural | Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses | JNKBP1 | Pattern recognition receptor (PRR) | TLR-deficient Mice on a C57BL/6 | monocyte/macrophages | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | ELISA | 24801735 | 2014 | Pubchem_assay |
| PRRID_1191 | Bropirimine Click for more detail | NA | C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | experimental drug with anti-cancer and antiviral properties | DUOX2 | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NYK1.fasta | Q9NYK1 | 1049 | important role in the immune response to viral infection | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1191 | Bropirimine Click for more detail | NA | C1=CC=C(C=C1)C2=C(C(=O)N=C(N2)N)Br | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | experimental drug with anti-cancer and antiviral properties | DUOX2 | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NYK1.fasta | Q9NYK1 | 1049 | important role in the immune response to viral infection | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1206 | CL075 Click for more detail | Thiazoloquinoline compound (others) | CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-κB and triggers preferentially the production of TNF-α and IL-12 | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Mice | dendritic cells, macrophages, natural killer cells | cell compartment | NA | NA | NA | important role in the immune response to viral infection | ELISA | 24771328 | 2014 | NA |
| PRRID_1206 | CL075 Click for more detail | Thiazoloquinoline compound (others) | CCCC1=NC2=C(S1)C3=CC=CC=C3N=C2N | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | stimulates TLR8 in human peripheral blood mononuclear cells. It activates NF-κB and triggers preferentially the production of TNF-α and IL-12 | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Mice | dendritic cells, macrophages, natural killer cells | cell compartment | NA | NA | NA | important role in the immune response to viral infection | ELISA | 24771328 | 2014 | NA |
| PRRID_1208 | CL097 Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N | NA | Nucleic Acid | Synthetic | It induces the activation of NF-κB | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Mice | dendritic cells, macrophages, natural killer cells | cell compartment | NA | NA | NA | important role in the immune response to viral infection | ELISA | 24771328 | 2014 | NA |
| PRRID_1208 | CL097 Click for more detail | imidazoquinoline (others) | CCOCC1=NC2=C(N1)C(=NC3=CC=CC=C32)N | NA | Nucleic Acid | Synthetic | It induces the activation of NF-κB | Toll-like receptor 7/8 (TLR7/8) | Toll-like receptor (TLR) | Mice | dendritic cells, macrophages, natural killer cells | cell compartment | NA | NA | NA | important role in the immune response to viral infection | ELISA | 24771328 | 2014 | NA |
| PRRID_1211 | CpG DNA Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | act as immuno stimulants | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | mast cells | cell compartment | Q9NR96.fasta | Q9NR96 | 1032 | TLR9 plays a crucial role in breaking tolerance and developing autoimmunity | T cell differentiation assay | 24760154 | 2014 | Pubchem_assay |
| PRRID_1211 | CpG DNA Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | act as immuno stimulants | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | mast cells | cell compartment | Q9NR96.fasta | Q9NR96 | 1032 | TLR9 plays a crucial role in breaking tolerance and developing autoimmunity | T cell differentiation assay | 24760154 | 2014 | Pubchem_assay |
| PRRID_1214 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | act as immuno stimulants | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | mast cells | cell compartment | Q9NR96.fasta | Q9NR96 | 1032 | TLR9 plays a crucial role in breaking tolerance and developing autoimmunity | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1214 | CpG motif Click for more detail | Bacteria | NA | NA | Nucleic Acid | Natural | act as immuno stimulants | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | mast cells | cell compartment | Q9NR96.fasta | Q9NR96 | 1032 | TLR9 plays a crucial role in breaking tolerance and developing autoimmunity | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1224 | CpG-ODN Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | act as immuno stimulants | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1224 | CpG-ODN Click for more detail | Bacteria | NA | NA | Nucleic Acid | Synthetic | act as immuno stimulants | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | Cell Compartment/Intracellular (Endosome) | Q9NR96.fasta | Q9NR96 | 1032 | induces pro-inflammatory cytokine response | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1229 | Defensins Click for more detail | Host (Endogenous) (others) | MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS | 69 | Peptide | Natural | Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Keratinocytes and mouse skin | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | play a role in UVB induced immune suppression | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1229 | Defensins Click for more detail | Host (Endogenous) (others) | MKTHYFLLVMICFLFSQMEPGVGILTSLGRRTDQYKCLQHGGFCLRSSCPSNTKLQGTCKPDKPNCCKS | 69 | Peptide | Natural | Defensins are cationic, microbicidal peptides active against many Gram-negative and Gram-positive bacteria, fungi, and enveloped viruses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Keratinocytes and mouse skin | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | play a role in UVB induced immune suppression | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1231 | dextran sodium sulphate and radiation Click for more detail | NA | CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | control intestinal epithelial homeostasis and provide protection from injury | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | NA | reverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis. | 24828022 | 2014 | Pubchem_assay |
| PRRID_1231 | dextran sodium sulphate and radiation Click for more detail | NA | CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | control intestinal epithelial homeostasis and provide protection from injury | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | NA | reverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis. | 24828022 | 2014 | Pubchem_assay |
| PRRID_1232 | dextran sodium sulphate and radiation Click for more detail | NA | CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | control intestinal epithelial homeostasis and provide protection from injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | NA | reverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis. | 24828022 | 2014 | Pubchem_assay |
| PRRID_1232 | dextran sodium sulphate and radiation Click for more detail | NA | CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | control intestinal epithelial homeostasis and provide protection from injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | NA | reverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis. | 24828022 | 2014 | Pubchem_assay |
| PRRID_1233 | dextran sodium sulphate and radiation Click for more detail | NA | CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | control intestinal epithelial homeostasis and provide protection from injury | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | NA | reverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis. | 24828022 | 2014 | Pubchem_assay |
| PRRID_1233 | dextran sodium sulphate and radiation Click for more detail | NA | CC1C(C(C(C(O1)OCC2C(C(C(C(O2)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)OS(=O)(=O)O)O | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | control intestinal epithelial homeostasis and provide protection from injury | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | NA | reverse transcription–polymerase chain reaction (RT–PCR), real-time RT–PCR, flow cytometry, immunocytochemistry and Western blot analysis. | 24828022 | 2014 | Pubchem_assay |
| PRRID_1235 | Diacylated Lipopeptide Click for more detail | Mycoplasma, Gram-positive bacteria | NA | NA | Fatty acid | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 24830024 | 2014 | NA |
| PRRID_1235 | Diacylated Lipopeptide Click for more detail | Mycoplasma, Gram-positive bacteria | NA | NA | Fatty acid | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2)/Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | Cell Surface (Exogenous) | NA | NA | NA | fundamental role in pathogen recognition and activation of innate immunity. | NA | 24830024 | 2014 | NA |
| PRRID_1236 | Diacylated Lipopeptide Click for more detail | Mycoplasma (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, mast cells and B-lymphocytes | cell surface | Q9EPW9.fasta | Q9EPW9 | 795 | significant role in the pathogenesis of severe inflammatory responses | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1236 | Diacylated Lipopeptide Click for more detail | Mycoplasma (Bacteria) | NA | NA | Pattern-associated molecular patterns (PAMPs) | Natural | elicit innate immune response | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, mast cells and B-lymphocytes | cell surface | Q9EPW9.fasta | Q9EPW9 | 795 | significant role in the pathogenesis of severe inflammatory responses | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1238 | Diacylated lipoprotein Click for more detail | Bacteria | NA | NA | Fatty acid | Natural | elicit innate immune response | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, mast cells and B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9EPW9.fasta | Q9EPW9 | 795 | significant role in the pathogenesis of severe inflammatory responses | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1238 | Diacylated lipoprotein Click for more detail | Bacteria | NA | NA | Fatty acid | Natural | elicit innate immune response | Toll-like receptor 6 (TLR6) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, mast cells and B-lymphocytes | extracellular domains of leucine-rich repeat motifs | Q9EPW9.fasta | Q9EPW9 | 795 | significant role in the pathogenesis of severe inflammatory responses | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1243 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | Cell Compartment/Intracellular (Endosome) | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1243 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | Cell Compartment/Intracellular (Endosome) | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1244 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | (DCs)Dendritic cells | cell surface | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | NA | 24825061 | 2014 | Pubchem_assay |
| PRRID_1244 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | (DCs)Dendritic cells | cell surface | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | NA | 24825061 | 2014 | Pubchem_assay |
| PRRID_1246 | dsRNA Click for more detail | RNA virus (Virus) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | cell compartment | Q99MB1.fasta | Q99MB1 | 905 | Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1246 | dsRNA Click for more detail | RNA virus (Virus) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | cell compartment | Q99MB1.fasta | Q99MB1 | 905 | Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1248 | dsRNA Click for more detail | Leishmania RNA virus (LRV) L. guyanensis (others) | NA | NA | Nucleic Acid | Natural | contributes to the exacerbation of disease and impacts inflammatory responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | C57BL/6 Mice | Dendritic Cell, B-lymphocyte | TRIF-dependent TLR3 | Q99MB1.fasta | Q99MB1 | 905 | an increased secretion of inflammatory cytokines and chemokines and exacerbated susceptibility to infection | NA | 24801628 | 2014 | Pubchem_assay |
| PRRID_1248 | dsRNA Click for more detail | Leishmania RNA virus (LRV) L. guyanensis (others) | NA | NA | Nucleic Acid | Natural | contributes to the exacerbation of disease and impacts inflammatory responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | C57BL/6 Mice | Dendritic Cell, B-lymphocyte | TRIF-dependent TLR3 | Q99MB1.fasta | Q99MB1 | 905 | an increased secretion of inflammatory cytokines and chemokines and exacerbated susceptibility to infection | NA | 24801628 | 2014 | Pubchem_assay |
| PRRID_1250 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Keratinocytes and mouse skin | cell compartment | Q99MB1.fasta | Q99MB1 | 905 | important for inflammation in the skin following injury | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1250 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Keratinocytes and mouse skin | cell compartment | Q99MB1.fasta | Q99MB1 | 905 | important for inflammation in the skin following injury | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1252 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | Cell Compartment/Intracellular (Endosome) | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1252 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | Cell Compartment/Intracellular (Endosome) | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1254 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | endosomes | LRR- and pyrin domain-containing 3 (NLRP3) | Q99MB1.fasta | Q99MB1 | 905 | production of pro-inflammatory cytokines | NA | 24762827 | 2014 | Pubchem_assay |
| PRRID_1254 | dsRNA Click for more detail | Virus | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | endosomes | LRR- and pyrin domain-containing 3 (NLRP3) | Q99MB1.fasta | Q99MB1 | 905 | production of pro-inflammatory cytokines | NA | 24762827 | 2014 | Pubchem_assay |
| PRRID_1256 | dsRNA Click for more detail | herpes simplex virus (virus) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1256 | dsRNA Click for more detail | herpes simplex virus (virus) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 3 (TLR3) | Toll-like receptor (TLR) | Mice | Dendritic Cell, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q99MB1.fasta | Q99MB1 | 905 | induce type I interferons (IFN) and other cytokines production. | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1259 | Endogenous DNA Click for more detail | DNA Virus(virus) | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | cell compartment | Q9NR96.fasta | Q9NR96 | 1032 | Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1259 | Endogenous DNA Click for more detail | DNA Virus(virus) | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | cell compartment | Q9NR96.fasta | Q9NR96 | 1032 | Possible effect in case of stroke i.e it is Involved in preconditioning and No protection after gene knockout following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1261 | Endogenous DNA from dead cells Click for more detail | Mice (others) | NA | NA | Nucleic Acid | Natural | EV71 induces cellular apoptosis, resulting in tissue damage; the endogenous DNA from dead cells activate the innate immune system through TLR9. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | Dendritic cells | LRR | Q9NR96.fasta | Q9NR96 | 1032 | This leads to the antiviral response against EV71 | Cytokines assay | 25078697 | 2014 | Pubchem_assay |
| PRRID_1261 | Endogenous DNA from dead cells Click for more detail | Mice (others) | NA | NA | Nucleic Acid | Natural | EV71 induces cellular apoptosis, resulting in tissue damage; the endogenous DNA from dead cells activate the innate immune system through TLR9. | Toll-like receptor 9 (TLR9) | Toll-like receptor (TLR) | Mice | Dendritic cells | LRR | Q9NR96.fasta | Q9NR96 | 1032 | This leads to the antiviral response against EV71 | Cytokines assay | 25078697 | 2014 | Pubchem_assay |
| PRRID_1262 | Endogenous RNA Click for more detail | RNA virus (Virus) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | cell compartment | P58681.fasta | P58681 | 1050 | Possible effect in case of stroke i.e it is Involved in preconditioning | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1262 | Endogenous RNA Click for more detail | RNA virus (Virus) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 7 (TLR7) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, plasmacytoid DCs and B-lymphocytes | cell compartment | P58681.fasta | P58681 | 1050 | Possible effect in case of stroke i.e it is Involved in preconditioning | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1264 | Endogenous RNA Click for more detail | RNA virus (Virus) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, mast cells | cell compartment | P58682.fasta | P58682 | 1032 | important role in the immune response to viral infection | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1264 | Endogenous RNA Click for more detail | RNA virus (Virus) | NA | NA | Nucleic Acid | Natural | triggers immune responses | Toll-like receptor 8 (TLR8) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs, mast cells | cell compartment | P58682.fasta | P58682 | 1032 | important role in the immune response to viral infection | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1266 | eosinophil-derived neurotoxin (EDN) Click for more detail | NA | MGPKLLESRLCLLLLLGLVLMLASCLGQTPSQWFAIQHINNNANLQCNVEMQRINRFRRTCKGLNTFLHTSFANAVGVCGNPSGLCSDNISRNCHNSSSRVRITVCNITSRRRTPYTQCRYQPRRSLEYYTVACNPRTPQDSPMYPVVPVHLDGTF | 156 | Damage-associated molecular patterns (DAMPs) | Natural | breakdown prod- ucts of extracellular matrix | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1266 | eosinophil-derived neurotoxin (EDN) Click for more detail | NA | MGPKLLESRLCLLLLLGLVLMLASCLGQTPSQWFAIQHINNNANLQCNVEMQRINRFRRTCKGLNTFLHTSFANAVGVCGNPSGLCSDNISRNCHNSSSRVRITVCNITSRRRTPYTQCRYQPRRSLEYYTVACNPRTPQDSPMYPVVPVHLDGTF | 156 | Damage-associated molecular patterns (DAMPs) | Natural | breakdown prod- ucts of extracellular matrix | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1269 | Fibrinogen Click for more detail | Host (Endogenous) (others) | MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG | 211 | Damage-associated molecular patterns (DAMPs) | Natural | initiates an inflammatory response by activating innate immune cells | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1269 | Fibrinogen Click for more detail | Host (Endogenous) (others) | MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG | 211 | Damage-associated molecular patterns (DAMPs) | Natural | initiates an inflammatory response by activating innate immune cells | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1271 | Fibrinogen Click for more detail | Host (Endogenous) (others) | MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG | 211 | Damage-associated molecular patterns (DAMPs) | Natural | initiates an inflammatory response by activating innate immune cells | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1271 | Fibrinogen Click for more detail | Host (Endogenous) (others) | MQNGAGASRTSTIFLNGNRERPLNVFCDMETDGGGWLVFQRRMDGQTDFWRDWEDYAHGFGNISGEFWLGNEALHSLTQAGDYSIRVDLRAGDEAVFAQYDSFHVDSAAEYYRLHLEGYHGTAGDSMSYHSGSVFSARDRDPNSLLISCAVSYRGAWWYRNCHYANLNGLYGSTVDHQGVSWYHWKGFEFSVPFTEMKLRPRNFRSPAGGG | 211 | Damage-associated molecular patterns (DAMPs) | Natural | initiates an inflammatory response by activating innate immune cells | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1274 | Fibronectin Click for more detail | Human (others) | MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP | 2386 | Glycoprotein | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1274 | Fibronectin Click for more detail | Human (others) | MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQSPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCYGGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDSMIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRPHETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYVVGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQDTRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHTSVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSGVVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYGGNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSNYEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHNYTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEICTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTCIAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFGQGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQCYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNSHPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLNSYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTSTPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVSASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLLPGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVDQVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLPETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQETTGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGYRVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFKVFAVSHGRESKPLTAQQTTKLDAP | 2386 | Glycoprotein | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1276 | Flagellin Click for more detail | Flagellated bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | It directly interacts with TLR 5 and induces immune response | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | Cell Surface (Exogenous) | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1276 | Flagellin Click for more detail | Flagellated bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | It directly interacts with TLR 5 and induces immune response | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | Cell Surface (Exogenous) | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 24830024 | 2014 | Pubchem_assay |
| PRRID_1278 | Flagellin Click for more detail | Flagellated bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1278 | Flagellin Click for more detail | Flagellated bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1281 | Flagellin Click for more detail | Flagellated bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | most abundant protein in the tails of most flagellated bacteria, has also been shown to be involved in host defence against UPEC | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | medullary collecting duct (MCD) cells | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | TLR5 plays a role in the control of the innate immune response in the urinary tract and stimulates the production of MIP-2/CXCL2 and KC/CXCL1, shown to play key roles in the chemoattraction of polymorphonuclear neutrophils (PMNs) | ELISA, adhesion and invasion assay | 24779433 | 2014 | Pubchem_assay |
| PRRID_1281 | Flagellin Click for more detail | Flagellated bacteria (Bacteria) | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | most abundant protein in the tails of most flagellated bacteria, has also been shown to be involved in host defence against UPEC | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | medullary collecting duct (MCD) cells | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | TLR5 plays a role in the control of the innate immune response in the urinary tract and stimulates the production of MIP-2/CXCL2 and KC/CXCL1, shown to play key roles in the chemoattraction of polymorphonuclear neutrophils (PMNs) | ELISA, adhesion and invasion assay | 24779433 | 2014 | Pubchem_assay |
| PRRID_1283 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | functions as a critical innate sensor for flagellated bacteria in all mucous organs | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | Neutrophils | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | important role in intestinal homeostasis mediating the immune adaptation to symbiotic microflora as well as defense against pathogenic bacterial infection | ELISA | 24778236 | 2014 | Pubchem_assay |
| PRRID_1283 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | functions as a critical innate sensor for flagellated bacteria in all mucous organs | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | Neutrophils | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | important role in intestinal homeostasis mediating the immune adaptation to symbiotic microflora as well as defense against pathogenic bacterial infection | ELISA | 24778236 | 2014 | Pubchem_assay |
| PRRID_1284 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | ELISA | 24771854 | 2014 | Pubchem_assay |
| PRRID_1284 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | ELISA | 24771854 | 2014 | Pubchem_assay |
| PRRID_1286 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | ELISA | 24771328 | 2014 | Pubchem_assay |
| PRRID_1286 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | cell surface | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | ELISA | 24771328 | 2014 | Pubchem_assay |
| PRRID_1288 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | Cell Surface (Exogenous) | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1288 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | Cell Surface (Exogenous) | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1290 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | extracellular domains of leucine-rich repeat motifs | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1290 | Flagellin Click for more detail | Bacteria | MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR | 495 | Protein | Natural | triggers immune responses | Toll-like receptor 5 (TLR5) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, DCs | extracellular domains of leucine-rich repeat motifs | Q9JLF7.fasta | Q9JLF7 | 859 | It stimulates the production of proinflammatory cytokines, such as TNF-α, through signaling via the adaptor protein MyD88. | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1304 | GLA( Glucopyranosyl lipid adjuvant) Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Spleen cells | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1304 | GLA( Glucopyranosyl lipid adjuvant) Click for more detail | NA | NA | NA | Pattern-associated molecular patterns (PAMPs) | Synthetic | NA | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Spleen cells | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | whole blood assay (WBA), ELISA | 24766820 | 2014 | Pubchem_assay |
| PRRID_1306 | Glycolipids Click for more detail | Mycobacteria (Bacteria) | NA | NA | Fatty acid | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | TLR-deficient Mice on a C57BL/6 | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | ELISA | 24801735 | 2014 | Pubchem_assay |
| PRRID_1306 | Glycolipids Click for more detail | Mycobacteria (Bacteria) | NA | NA | Fatty acid | Natural | elicit innate immune response | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | TLR-deficient Mice on a C57BL/6 | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | significant role in the pathogenesis of severe inflammatory responses | ELISA | 24801735 | 2014 | Pubchem_assay |
| PRRID_1307 | Heat shock protein Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | released in responses to local stresses (hypoxia or inflammation) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | (DCs)Dendritic cells | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24825061 | 2014 | Pubchem_assay |
| PRRID_1307 | Heat shock protein Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | released in responses to local stresses (hypoxia or inflammation) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | (DCs)Dendritic cells | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR 4 leads to an intracellular signaling pathway NF-κB and inflammatory cytokine production which is responsible for activating the innate immune system | NA | 24825061 | 2014 | Pubchem_assay |
| PRRID_1309 | Heat shock protein Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | released in responses to local stresses (hypoxia or inflammation) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Keratinocytes and mouse skin | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | play a role in UVB induced immune suppression | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1309 | Heat shock protein Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | released in responses to local stresses (hypoxia or inflammation) | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | Keratinocytes and mouse skin | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | play a role in UVB induced immune suppression | NA | 24786223 | 2014 | Pubchem_assay |
| PRRID_1311 | Heat shock protein Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | released in brain injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | ischemic brain tissue | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon | NA | 24784586 | 2014 | Pubchem_assay |
| PRRID_1311 | Heat shock protein Click for more detail | NA | NA | NA | Damage-associated molecular patterns (DAMPs) | Natural | released in brain injury | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | ischemic brain tissue | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | TLR4 signaling has been implicated in post-stroke neuroinflammation and injury and is also critical in the robustly neuroprotective ischemic preconditioning phenomenon | NA | 24784586 | 2014 | Pubchem_assay |
| PRRID_1313 | Heat-shock protein 70 Click for more detail | NA | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Damage-associated molecular patterns (DAMPs) | Natural | endogenous Ligand HSP70 induces proinflammatory cytokines through TLR2 and initiates an inflammatory response by activating innate immune cells | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1313 | Heat-shock protein 70 Click for more detail | NA | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Damage-associated molecular patterns (DAMPs) | Natural | endogenous Ligand HSP70 induces proinflammatory cytokines through TLR2 and initiates an inflammatory response by activating innate immune cells | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1315 | Heat-shock protein 70 Click for more detail | NA | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Damage-associated molecular patterns (DAMPs) | Natural | endogenous Ligand HSP70 induces proinflammatory cytokines through TLR2 and TLR4 signaling | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1315 | Heat-shock protein 70 Click for more detail | NA | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Damage-associated molecular patterns (DAMPs) | Natural | endogenous Ligand HSP70 induces proinflammatory cytokines through TLR2 and TLR4 signaling | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | cell surface | Q9QUK6.fasta | Q9QUK6 | 835 | Possible effect in case of stroke i.e it is Involved in preconditioning, Up-regulation of TLR4 mRNA correlates with the severity of ischemia, TLR4-deficient animals have better outcome following cerebral ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1317 | Heat-shock protein 70 Click for more detail | NA | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1317 | Heat-shock protein 70 Click for more detail | NA | MAKNTAIGIDLGTTYSCVGVFQHGKVEIIANDQGNRTTPSYVAFTDTERLIGDAAKNQVALNPQNTVFDAKRLIGRKFGDAVVQSDMKHWPFQVVNDGDKPKVQVNYKGESRSFFPEEISSMVLTKIKEIAEAYLGHPVTNAVITVPAYFNDSQRQATKDAGVIAGLNVLRIINEPTAAAIAYGLDRTGKGERNVLIFDLGGGTFDVSILTIDDGIFEVKATAGDTHLGGEDFDNRLVSHFVEEFKRKHKKDISQNKRAVRRLRTACERAKRTLSSSTQASLEIDSLFEAIDFYTSITRARFEELCSDLFRGTLEPVEKALRDAKMDKAQIHDLVLVGGSTRIPKVQKLLQDFFNGRDLNKSINPDEAVAYGAAVQAAILMRDKSENVQDLLLLDVAPLSLGPEAAGGVMTALIKRNSTIPTKQTQTFTTYSDNQPGVLIQVYEGERAMTRDNNLLGRFELSGIPPAPRGVPQIEVTFDIDANGILNVTATDKSTGKANKITITNDKGRLSKEEIERMVQEAERYKAEDEVQRDRVAAKNALESYAFNMKSAVEDEGLKGKLSEADKKKVLDKCQEVISWLDSNTLADKEEFVHKREELERVCSPIISGLYQGAGAPGAGGFGAQAPMGASGSGPTIEEVD | 641 | Damage-associated molecular patterns (DAMPs) | Natural | triggers immune responses | Toll-like receptor 4 (TLR4) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte | signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF) | Q9QUK6.fasta | Q9QUK6 | 835 | plays a fundamental role in pathogen recognition and activation of innate immunity | NA | 24754320 | 2014 | Pubchem_assay |
| PRRID_1319 | Heat-shock proteins 60 Click for more detail | NA | MLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Damage-associated molecular patterns (DAMPs) | Natural | initiates an inflammatory response by activating innate immune cells | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |
| PRRID_1319 | Heat-shock proteins 60 Click for more detail | NA | MLRLPTVLRQMRPVSRALAPHLTRAYAKDVKFGADARALMLQGVDLLADAVAVTMGPKGRTVIIEQSWGSPKVTKDGVTVAKSIDLKDKYKNIGAKLVQDVANNTNEEAGDGTTTATVLARSIAKEGFEKISKGANPVEIRRGVMLAVDAVIAELKKQSKPVTTPEEIAQVATISANGDKDIGNIISDAMKKVGRKGVITVKDGKTLNDELEIIEGMKFDRGYISPYFINTSKGQKCEFQDAYVLLSEKKISSVQSIVPALEIANAHRKPLVIIAEDVDGEALSTLVLNRLKVGLQVVAVKAPGFGDNRKNQLKDMAIATGGAVFGEEGLNLNLEDVQAHDLGKVGEVIVTKDDAMLLKGKGDKAHIEKRIQEITEQLDITTSEYEKEKLNERLAKLSDGVAVLKVGGTSDVEVNEKKDRVTDALNATRAAVEEGIVLGGGCALLRCIPALDSLKPANEDQKIGIEIIKRALKIPAMTIAKNAGVEGSLIVEKILQSSSEVGYDAMLGDFVNMVEKGIIDPTKVVRTALLDAAGVASLLTTAEAVVTEIPKEEKDPGMGAMGGMGGGMGGGMF | 573 | Damage-associated molecular patterns (DAMPs) | Natural | initiates an inflammatory response by activating innate immune cells | Toll-like receptor 2 (TLR2) | Toll-like receptor (TLR) | Mice | monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells | cell surface | Q9QUN7.fasta | Q9QUN7 | 784 | Possible effect in case of stroke i.e Up-regulation of TLR2 mRNA correlates with severity of ischemia | NA | 24807166 | 2014 | Pubchem_assay |