Browse By Oncolytic Virus Species Result Page of OvirusTdb

The Total number of records shown on this page is 100. Click on ID to see further detail.
IDOV_1Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result59% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_2Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration100 MOIIn-vitro result56% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_3Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration200 MOIIn-vitro result49% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_4Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result90% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_5Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration100 MOIIn-vitro result78% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_6Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration200 MOIIn-vitro result78% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_7Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result70% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_8Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration100 MOIIn-vitro result60% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_9Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration200 MOIIn-vitro result38% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_10Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineMIAPaCa-2Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result70% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_11Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineMIAPaCa-2Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result58% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_12Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineMIAPaCa-2Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration100 MOIIn-vitro result38% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_13Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineMIAPaCa-2Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_14Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineMIAPaCa-2Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result95% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_15Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineMIAPaCa-2Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration100 MOIIn-vitro result94% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_16Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineMIAPaCa-2Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result77% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_17Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineMIAPaCa-2Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration50 MOIIn-vitro result72% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_18Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineMIAPaCa-2Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration100 MOIIn-vitro result58% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_19Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result70% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_20Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result58% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_21Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result38% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_22Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_23Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result95% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_24Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result94% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_25Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration1 MOIIn-vitro result77% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_26Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result72% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_27Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result58% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_28Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineAsPC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result80% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_29Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineAsPC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result78% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_30Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineAsPC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration20 MOIIn-vitro result40% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_31Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineAsPC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result90% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_32Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineAsPC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result82% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_33Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineAsPC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration20 MOIIn-vitro result84% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_34Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineAsPC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration5 MOIIn-vitro result89% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_35Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineAsPC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result94% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_36Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell lineAsPC-1Concentration of cell lineGrown to 70% confluenceIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration20 MOIIn-vitro result94% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_37Virus nameAdenovirusVirus strainoAd/DCN/LRPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/c nude mice xenograft for MIA PaCa-2 cell line 5.0E+6 cellsIn-vivo virus concentration2.0E+10 VP (on 0, 2, and 4 days)In-vivo toxicitySlight hepatotoxicity In-vivo resultReduction in tumor volume to 230 cubic millimeter compared to control 300 cubic millimeter after 46 daysMode of deliveryIntravenouslyPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectIL-6 production increased by 3 folds as compared to normalClinical trialNAPMID26471393
IDOV_38Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEGVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/c nude mice xenograft for MIA PaCa-2 cell line 5.0E+4 cellsIn-vivo virus concentration2.0E+10 VP (on 0, 2, and 4 days)In-vivo toxicityNA In-vivo resultReduction in tumor volume to 198 cubic millimeter compared to control 300 cubic millimeter after 46 daysMode of deliveryIntravenouslyPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_39Virus nameAdenovirusVirus strainoAd/DCN/LRP-PEG-NTVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycolVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/c nude mice xenograft for MIA PaCa-2 cell line 5.0E+4 cellsIn-vivo virus concentration2.0E+10 VP (on 0, 2, and 4 days)In-vivo toxicityNA In-vivo resultReduction in tumor volume to 100 cubic millimeter compared to control 300 cubic millimeter after 46 daysMode of deliveryIntravenouslyPathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathwaysImmunogenic effectNAClinical trialNAPMID26471393
IDOV_40Virus nameAdenovirusVirus strainAdCMV/GFPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationMutant with E1 deletion carrying a green fluorescent protein (GFP)Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineDesnity of 1000000 in 60mm dishIn-vitro toxicityHighly toxic to NIH/3T3 as measured by crystal violet staining at 10 MOIAssayMTT assayIn-vitro virus concentration3.5 MOIIn-vitro result13% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26475304
IDOV_41Virus nameAdenovirusVirus strainAd dl1520Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b mutant with 827-bp deletion and a point mutation with premature stop codon in the E1B55K coding regionVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineDesnity of 1000000 in 60mm dishIn-vitro toxicityMinimal toxic to NIH/3T3 as measured by crystal violet staining at 10 MOIAssayMTT assayIn-vitro virus concentration3.5 MOIIn-vitro result54% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26475304
IDOV_42Virus nameAdenovirusVirus strainAd-cycEVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutant with a human cyclin E promoter driving an intact E1A expression cassetteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell lineDesnity of 1000000 in 60mm dishIn-vitro toxicityMinimal toxic to NIH/3T3 as measured by crystal violet staining at 10 MOIAssayMTT assayIn-vitro virus concentration3.5 MOIIn-vitro result18% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivates CDK2 and targets the transcriptional repressor pRbClinical trialNAPMID26475304
IDOV_43Virus nameAdenovirusVirus strainAdCMV/GFPVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationMutant with E1 deletion carrying a green fluorescent protein (GFP)Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine lung cancer cell lineCell lineED-1Concentration of cell lineDesnity of 1000000 in 60mm dishIn-vitro toxicityHighly toxic to NIH/3T3 as measured by crystal violet staining at 10 MOIAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result22% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26475304
IDOV_44Virus nameAdenovirusVirus strainAd dl1520Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b mutant with 827-bp deletion and a point mutation with premature stop codon in the E1B55K coding regionVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine lung cancer cell lineCell lineED-1Concentration of cell lineDesnity of 1000000 in 60mm dishIn-vitro toxicityMinimal toxic to NIH/3T3 as measured by crystal violet staining at 10 MOIAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result55% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26475304
IDOV_45Virus nameAdenovirusVirus strainAd-cycEVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutant with a human cyclin E promoter driving an intact E1A expression cassetteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMurine lung cancer cell lineCell lineED-1Concentration of cell lineDesnity of 1000000 in 60mm dishIn-vitro toxicityMinimal toxic to NIH/3T3 as measured by crystal violet staining at 10 MOIAssayMTT assayIn-vitro virus concentration10 MOIIn-vitro result55% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectActivates CDK2 and targets the transcriptional repressor pRbClinical trialNAPMID26475304
IDOV_46Virus nameAdenovirusVirus strainAd-cycEVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1b-deleted mutant with a human cyclin E promoter driving an intact E1A expression cassetteVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismFemale FVB/NCr mice isograft for 5.0E+6 cells ED-1 murine lung cancer cell linesIn-vivo virus concentration1.5E+9 IFU (on 0, 2, 4 and 6 days)In-vivo toxicityNA In-vivo resultReduction in tumor volume to 52 cubic millimeter compared to control 150 cubic millimeter after 36 daysMode of deliveryIntratumorallyPathway inducedNAImmunogenic effectActivates CDK2 and targets the transcriptional repressor pRbClinical trialNAPMID26475304
IDOV_47Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result57% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_48Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with etoposide (0.5 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.67 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result24% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_49Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with epirubicin (0.5 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.46 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result16% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_50Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with doxorubicin (0.1 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.88 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result26% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_51Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with vincristine (0.1 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.79 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result25% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_52Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with colchcine (0.02 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.81 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result28% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_53Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicityNAAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result18% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_54Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with etoposide (0.5 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.27 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result4% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_55Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with epirubicin (0.5 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.31 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result4% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_56Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with doxorubicin (0.1 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.33 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result6% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_57Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with vincristine (0.1 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.89 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result12% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_58Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneNoVirus in combination with drug/radiationViral strain in combination with colchcine (0.02 μg/ml)Immune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman lung cancer cell lineCell lineA549Concentration of cell line1.0E+6 cells per wellIn-vitro toxicity0.78 CDIAssayMTT assayIn-vitro virus concentration0.1 MOIIn-vitro result10% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_59Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (YB-1 gene knockdown)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.01 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_60Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (YB-1 gene knockdown)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.1 MOIIn-vitro result90% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_61Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (YB-1 gene knockdown)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro result40% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_62Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (YB-1 gene knockdown)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result2% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_63Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged YB-1 gene overexpressed)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.001 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_64Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged YB-1 gene overexpressed)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.01 MOIIn-vitro result90% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_65Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged YB-1 gene overexpressed)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.1 MOIIn-vitro result60% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_66Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged YB-1 gene overexpressed)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro result4% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_67Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged YB-1 gene overexpressed)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result1% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_68Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.001 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_69Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.01 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_70Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.1 MOIIn-vitro result96% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_71Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro result80% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_72Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result20% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_73Virus nameAdenovirusVirus strainAdLacZVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1/E3-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged YB-1 gene overexpressed)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.01 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_74Virus nameAdenovirusVirus strainAdLacZVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1/E3-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged YB-1 gene overexpressed)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.1 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_75Virus nameAdenovirusVirus strainAdLacZVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1/E3-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged YB-1 gene overexpressed)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_76Virus nameAdenovirusVirus strainAdLacZVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1/E3-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged YB-1 gene overexpressed)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_77Virus nameAdenovirusVirus strainAdLacZVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1/E3-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.01 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_78Virus nameAdenovirusVirus strainAdLacZVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1/E3-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.1 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_79Virus nameAdenovirusVirus strainAdLacZVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1/E3-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_80Virus nameAdenovirusVirus strainAdLacZVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1/E3-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_81Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (YB-1 gene knockdown)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.01 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_82Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (YB-1 gene knockdown)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.1 MOIIn-vitro result85% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_83Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (YB-1 gene knockdown)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro result35% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_84Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (YB-1 gene knockdown)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result1% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_85Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged YB-1 gene overexpressed)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.001 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_86Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged YB-1 gene overexpressed)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.01 MOIIn-vitro result90% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_87Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged YB-1 gene overexpressed)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.1 MOIIn-vitro result20% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_88Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged YB-1 gene overexpressed)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro result2% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_89Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged YB-1 gene overexpressed)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result1% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_90Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.001 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_91Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.01 MOIIn-vitro result100% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_92Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration0.1 MOIIn-vitro result94% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_93Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration1 MOIIn-vitro result75% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_94Virus nameAdenovirusVirus strainAd5GS3Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the MDR1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineHuman breast cancer lineCell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation)Concentration of cell lineNAIn-vitro toxicityNAAssayCrystal violet stainingIn-vitro virus concentration10 MOIIn-vitro result16% cancer cell viabilityModel organismNoIn-vivo virus concentrationNoIn-vivo toxicityNA In-vivo resultNo responseMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_95Virus nameAdenovirusVirus strainAdLacZVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1/E3-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismClinical lung adenocarcinoma tissue (Primary cancer cells, Stage IA)In-vivo virus concentration0.01 MOIIn-vivo toxicityNA In-vivo result100% cancer cell viabilityMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_96Virus nameAdenovirusVirus strainAdLacZVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1/E3-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismClinical lung adenocarcinoma tissue (Primary cancer cells, Stage IA)In-vivo virus concentration0.1 MOIIn-vivo toxicityNA In-vivo result100% cancer cell viabilityMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_97Virus nameAdenovirusVirus strainAdLacZVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1/E3-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismClinical lung adenocarcinoma tissue (Primary cancer cells, Stage IA)In-vivo virus concentration1 MOIIn-vivo toxicityNA In-vivo result100% cancer cell viabilityMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_98Virus nameAdenovirusVirus strainAdLacZVirus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1/E3-deleted mutantVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismClinical lung adenocarcinoma tissue (Primary cancer cells, Stage IA)In-vivo virus concentration10 MOIIn-vivo toxicityNA In-vivo result100% cancer cell viabilityMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_99Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismClinical lung adenocarcinoma tissue (Primary cancer cells, Stage IA)In-vivo virus concentration0.01 MOIIn-vivo toxicityNA In-vivo result100% cancer cell viabilityMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462
IDOV_100Virus nameAdenovirusVirus strainAd5WS1Virus genome typeDNAVirus familyAdenoviridaeVirus genome modificationE1B55K-deleted mutant driven by the E1 promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismClinical lung adenocarcinoma tissue (Primary cancer cells, Stage IA)In-vivo virus concentration0.1 MOIIn-vivo toxicityNA In-vivo result100% cancer cell viabilityMode of deliveryNAPathway inducedNAImmunogenic effectNAClinical trialNAPMID26515462