Browse By Oncolytic Virus Species Result Page of OvirusTdb
The Total number of records shown on this page is 100. Click on ID to see further detail.
IDOV_1 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell linePANC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration50 MOI | In-vitro result59% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectIL-6 production increased by 3 folds as compared to normal | Clinical trialNA | PMID26471393 |
IDOV_2 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell linePANC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration100 MOI | In-vitro result56% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectIL-6 production increased by 3 folds as compared to normal | Clinical trialNA | PMID26471393 |
IDOV_3 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell linePANC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration200 MOI | In-vitro result49% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectIL-6 production increased by 3 folds as compared to normal | Clinical trialNA | PMID26471393 |
IDOV_4 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell linePANC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration50 MOI | In-vitro result90% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_5 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell linePANC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration100 MOI | In-vitro result78% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_6 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell linePANC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration200 MOI | In-vitro result78% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_7 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG-NT | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell linePANC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration50 MOI | In-vitro result70% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_8 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG-NT | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell linePANC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration100 MOI | In-vitro result60% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_9 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG-NT | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell linePANC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration200 MOI | In-vitro result38% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_10 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineMIAPaCa-2 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration10 MOI | In-vitro result70% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectIL-6 production increased by 3 folds as compared to normal | Clinical trialNA | PMID26471393 |
IDOV_11 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineMIAPaCa-2 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration50 MOI | In-vitro result58% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectIL-6 production increased by 3 folds as compared to normal | Clinical trialNA | PMID26471393 |
IDOV_12 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineMIAPaCa-2 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration100 MOI | In-vitro result38% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectIL-6 production increased by 3 folds as compared to normal | Clinical trialNA | PMID26471393 |
IDOV_13 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineMIAPaCa-2 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration10 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_14 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineMIAPaCa-2 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration50 MOI | In-vitro result95% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_15 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineMIAPaCa-2 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration100 MOI | In-vitro result94% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_16 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG-NT | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineMIAPaCa-2 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration10 MOI | In-vitro result77% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_17 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG-NT | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineMIAPaCa-2 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration50 MOI | In-vitro result72% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_18 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG-NT | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineMIAPaCa-2 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration100 MOI | In-vitro result58% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_19 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration1 MOI | In-vitro result70% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectIL-6 production increased by 3 folds as compared to normal | Clinical trialNA | PMID26471393 |
IDOV_20 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration5 MOI | In-vitro result58% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectIL-6 production increased by 3 folds as compared to normal | Clinical trialNA | PMID26471393 |
IDOV_21 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration10 MOI | In-vitro result38% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectIL-6 production increased by 3 folds as compared to normal | Clinical trialNA | PMID26471393 |
IDOV_22 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration1 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_23 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration5 MOI | In-vitro result95% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_24 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration10 MOI | In-vitro result94% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_25 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG-NT | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration1 MOI | In-vitro result77% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_26 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG-NT | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration5 MOI | In-vitro result72% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_27 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG-NT | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration10 MOI | In-vitro result58% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_28 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineAsPC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration5 MOI | In-vitro result80% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectIL-6 production increased by 3 folds as compared to normal | Clinical trialNA | PMID26471393 |
IDOV_29 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineAsPC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration10 MOI | In-vitro result78% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectIL-6 production increased by 3 folds as compared to normal | Clinical trialNA | PMID26471393 |
IDOV_30 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineAsPC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration20 MOI | In-vitro result40% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectIL-6 production increased by 3 folds as compared to normal | Clinical trialNA | PMID26471393 |
IDOV_31 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineAsPC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration5 MOI | In-vitro result90% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_32 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineAsPC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration10 MOI | In-vitro result82% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_33 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineAsPC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration20 MOI | In-vitro result84% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_34 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG-NT | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineAsPC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration5 MOI | In-vitro result89% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_35 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG-NT | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineAsPC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration10 MOI | In-vitro result94% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_36 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG-NT | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman pancreatic cancer cell line | Cell lineAsPC-1 | Concentration of cell lineGrown to 70% confluence | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration20 MOI | In-vitro result94% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_37 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismBALB/c nude mice xenograft for MIA PaCa-2 cell line 5.0E+6 cells | In-vivo virus concentration2.0E+10 VP (on 0, 2, and 4 days) | In-vivo toxicitySlight hepatotoxicity | In-vivo resultReduction in tumor volume to 230 cubic millimeter compared to control 300 cubic millimeter after 46 days | Mode of deliveryIntravenously | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectIL-6 production increased by 3 folds as compared to normal | Clinical trialNA | PMID26471393 |
IDOV_38 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismBALB/c nude mice xenograft for MIA PaCa-2 cell line 5.0E+4 cells | In-vivo virus concentration2.0E+10 VP (on 0, 2, and 4 days) | In-vivo toxicityNA | In-vivo resultReduction in tumor volume to 198 cubic millimeter compared to control 300 cubic millimeter after 46 days | Mode of deliveryIntravenously | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_39 | Virus nameAdenovirus | Virus strainoAd/DCN/LRP-PEG-NT | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationInsertional mutant for DCN and LRP gene with NT-conjugated polyethylene glycol | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismBALB/c nude mice xenograft for MIA PaCa-2 cell line 5.0E+4 cells | In-vivo virus concentration2.0E+10 VP (on 0, 2, and 4 days) | In-vivo toxicityNA | In-vivo resultReduction in tumor volume to 100 cubic millimeter compared to control 300 cubic millimeter after 46 days | Mode of deliveryIntravenously | Pathway inducedInhibits Wnt/β-catenin and TGF-β1 signaling pathways | Immunogenic effectNA | Clinical trialNA | PMID26471393 |
IDOV_40 | Virus nameAdenovirus | Virus strainAdCMV/GFP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationMutant with E1 deletion carrying a green fluorescent protein (GFP) | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell lineDesnity of 1000000 in 60mm dish | In-vitro toxicityHighly toxic to NIH/3T3 as measured by crystal violet staining at 10 MOI | AssayMTT assay | In-vitro virus concentration3.5 MOI | In-vitro result13% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26475304 |
IDOV_41 | Virus nameAdenovirus | Virus strainAd dl1520 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1b mutant with 827-bp deletion and a point mutation with premature stop codon in the E1B55K coding region | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell lineDesnity of 1000000 in 60mm dish | In-vitro toxicityMinimal toxic to NIH/3T3 as measured by crystal violet staining at 10 MOI | AssayMTT assay | In-vitro virus concentration3.5 MOI | In-vitro result54% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26475304 |
IDOV_42 | Virus nameAdenovirus | Virus strainAd-cycE | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1b-deleted mutant with a human cyclin E promoter driving an intact E1A expression cassette | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell lineDesnity of 1000000 in 60mm dish | In-vitro toxicityMinimal toxic to NIH/3T3 as measured by crystal violet staining at 10 MOI | AssayMTT assay | In-vitro virus concentration3.5 MOI | In-vitro result18% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectActivates CDK2 and targets the transcriptional repressor pRb | Clinical trialNA | PMID26475304 |
IDOV_43 | Virus nameAdenovirus | Virus strainAdCMV/GFP | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationMutant with E1 deletion carrying a green fluorescent protein (GFP) | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineMurine lung cancer cell line | Cell lineED-1 | Concentration of cell lineDesnity of 1000000 in 60mm dish | In-vitro toxicityHighly toxic to NIH/3T3 as measured by crystal violet staining at 10 MOI | AssayMTT assay | In-vitro virus concentration10 MOI | In-vitro result22% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26475304 |
IDOV_44 | Virus nameAdenovirus | Virus strainAd dl1520 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1b mutant with 827-bp deletion and a point mutation with premature stop codon in the E1B55K coding region | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineMurine lung cancer cell line | Cell lineED-1 | Concentration of cell lineDesnity of 1000000 in 60mm dish | In-vitro toxicityMinimal toxic to NIH/3T3 as measured by crystal violet staining at 10 MOI | AssayMTT assay | In-vitro virus concentration10 MOI | In-vitro result55% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26475304 |
IDOV_45 | Virus nameAdenovirus | Virus strainAd-cycE | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1b-deleted mutant with a human cyclin E promoter driving an intact E1A expression cassette | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineATCC | Origin of cell lineMurine lung cancer cell line | Cell lineED-1 | Concentration of cell lineDesnity of 1000000 in 60mm dish | In-vitro toxicityMinimal toxic to NIH/3T3 as measured by crystal violet staining at 10 MOI | AssayMTT assay | In-vitro virus concentration10 MOI | In-vitro result55% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectActivates CDK2 and targets the transcriptional repressor pRb | Clinical trialNA | PMID26475304 |
IDOV_46 | Virus nameAdenovirus | Virus strainAd-cycE | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1b-deleted mutant with a human cyclin E promoter driving an intact E1A expression cassette | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismFemale FVB/NCr mice isograft for 5.0E+6 cells ED-1 murine lung cancer cell lines | In-vivo virus concentration1.5E+9 IFU (on 0, 2, 4 and 6 days) | In-vivo toxicityNA | In-vivo resultReduction in tumor volume to 52 cubic millimeter compared to control 150 cubic millimeter after 36 days | Mode of deliveryIntratumorally | Pathway inducedNA | Immunogenic effectActivates CDK2 and targets the transcriptional repressor pRb | Clinical trialNA | PMID26475304 |
IDOV_47 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell line1.0E+6 cells per well | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration0.1 MOI | In-vitro result57% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_48 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneNo | Virus in combination with drug/radiationViral strain in combination with etoposide (0.5 μg/ml) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell line1.0E+6 cells per well | In-vitro toxicity0.67 CDI | AssayMTT assay | In-vitro virus concentration0.1 MOI | In-vitro result24% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_49 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneNo | Virus in combination with drug/radiationViral strain in combination with epirubicin (0.5 μg/ml) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell line1.0E+6 cells per well | In-vitro toxicity0.46 CDI | AssayMTT assay | In-vitro virus concentration0.1 MOI | In-vitro result16% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_50 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneNo | Virus in combination with drug/radiationViral strain in combination with doxorubicin (0.1 μg/ml) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell line1.0E+6 cells per well | In-vitro toxicity0.88 CDI | AssayMTT assay | In-vitro virus concentration0.1 MOI | In-vitro result26% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_51 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneNo | Virus in combination with drug/radiationViral strain in combination with vincristine (0.1 μg/ml) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell line1.0E+6 cells per well | In-vitro toxicity0.79 CDI | AssayMTT assay | In-vitro virus concentration0.1 MOI | In-vitro result25% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_52 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneNo | Virus in combination with drug/radiationViral strain in combination with colchcine (0.02 μg/ml) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell line1.0E+6 cells per well | In-vitro toxicity0.81 CDI | AssayMTT assay | In-vitro virus concentration0.1 MOI | In-vitro result28% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_53 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell line1.0E+6 cells per well | In-vitro toxicityNA | AssayMTT assay | In-vitro virus concentration0.1 MOI | In-vitro result18% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_54 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneNo | Virus in combination with drug/radiationViral strain in combination with etoposide (0.5 μg/ml) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell line1.0E+6 cells per well | In-vitro toxicity0.27 CDI | AssayMTT assay | In-vitro virus concentration0.1 MOI | In-vitro result4% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_55 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneNo | Virus in combination with drug/radiationViral strain in combination with epirubicin (0.5 μg/ml) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell line1.0E+6 cells per well | In-vitro toxicity0.31 CDI | AssayMTT assay | In-vitro virus concentration0.1 MOI | In-vitro result4% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_56 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneNo | Virus in combination with drug/radiationViral strain in combination with doxorubicin (0.1 μg/ml) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell line1.0E+6 cells per well | In-vitro toxicity0.33 CDI | AssayMTT assay | In-vitro virus concentration0.1 MOI | In-vitro result6% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_57 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneNo | Virus in combination with drug/radiationViral strain in combination with vincristine (0.1 μg/ml) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell line1.0E+6 cells per well | In-vitro toxicity0.89 CDI | AssayMTT assay | In-vitro virus concentration0.1 MOI | In-vitro result12% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_58 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneNo | Virus in combination with drug/radiationViral strain in combination with colchcine (0.02 μg/ml) | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman lung cancer cell line | Cell lineA549 | Concentration of cell line1.0E+6 cells per well | In-vitro toxicity0.78 CDI | AssayMTT assay | In-vitro virus concentration0.1 MOI | In-vitro result10% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_59 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (YB-1 gene knockdown) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.01 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_60 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (YB-1 gene knockdown) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.1 MOI | In-vitro result90% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_61 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (YB-1 gene knockdown) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration1 MOI | In-vitro result40% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_62 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (YB-1 gene knockdown) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration10 MOI | In-vitro result2% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_63 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged YB-1 gene overexpressed) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.001 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_64 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged YB-1 gene overexpressed) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.01 MOI | In-vitro result90% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_65 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged YB-1 gene overexpressed) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.1 MOI | In-vitro result60% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_66 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged YB-1 gene overexpressed) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration1 MOI | In-vitro result4% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_67 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged YB-1 gene overexpressed) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration10 MOI | In-vitro result1% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_68 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.001 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_69 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.01 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_70 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.1 MOI | In-vitro result96% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_71 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration1 MOI | In-vitro result80% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_72 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration10 MOI | In-vitro result20% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_73 | Virus nameAdenovirus | Virus strainAdLacZ | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1/E3-deleted mutant | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged YB-1 gene overexpressed) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.01 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_74 | Virus nameAdenovirus | Virus strainAdLacZ | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1/E3-deleted mutant | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged YB-1 gene overexpressed) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.1 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_75 | Virus nameAdenovirus | Virus strainAdLacZ | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1/E3-deleted mutant | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged YB-1 gene overexpressed) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration1 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_76 | Virus nameAdenovirus | Virus strainAdLacZ | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1/E3-deleted mutant | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged YB-1 gene overexpressed) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration10 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_77 | Virus nameAdenovirus | Virus strainAdLacZ | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1/E3-deleted mutant | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.01 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_78 | Virus nameAdenovirus | Virus strainAdLacZ | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1/E3-deleted mutant | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.1 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_79 | Virus nameAdenovirus | Virus strainAdLacZ | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1/E3-deleted mutant | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration1 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_80 | Virus nameAdenovirus | Virus strainAdLacZ | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1/E3-deleted mutant | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration10 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_81 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (YB-1 gene knockdown) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.01 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_82 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (YB-1 gene knockdown) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.1 MOI | In-vitro result85% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_83 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (YB-1 gene knockdown) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration1 MOI | In-vitro result35% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_84 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (YB-1 gene knockdown) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration10 MOI | In-vitro result1% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_85 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged YB-1 gene overexpressed) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.001 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_86 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged YB-1 gene overexpressed) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.01 MOI | In-vitro result90% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_87 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged YB-1 gene overexpressed) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.1 MOI | In-vitro result20% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_88 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged YB-1 gene overexpressed) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration1 MOI | In-vitro result2% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_89 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged YB-1 gene overexpressed) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration10 MOI | In-vitro result1% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_90 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.001 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_91 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.01 MOI | In-vitro result100% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_92 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration0.1 MOI | In-vitro result94% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_93 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration1 MOI | In-vitro result75% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_94 | Virus nameAdenovirus | Virus strainAd5GS3 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the MDR1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineHuman breast cancer line | Cell lineMCF-7 (HA-tagged mutant YB-1(S102A) gene overexpression, mutation at Akt phosphorylation site which leads to failed nuclear translocation) | Concentration of cell lineNA | In-vitro toxicityNA | AssayCrystal violet staining | In-vitro virus concentration10 MOI | In-vitro result16% cancer cell viability | Model organismNo | In-vivo virus concentrationNo | In-vivo toxicityNA | In-vivo resultNo response | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_95 | Virus nameAdenovirus | Virus strainAdLacZ | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1/E3-deleted mutant | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismClinical lung adenocarcinoma tissue (Primary cancer cells, Stage IA) | In-vivo virus concentration0.01 MOI | In-vivo toxicityNA | In-vivo result100% cancer cell viability | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_96 | Virus nameAdenovirus | Virus strainAdLacZ | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1/E3-deleted mutant | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismClinical lung adenocarcinoma tissue (Primary cancer cells, Stage IA) | In-vivo virus concentration0.1 MOI | In-vivo toxicityNA | In-vivo result100% cancer cell viability | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_97 | Virus nameAdenovirus | Virus strainAdLacZ | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1/E3-deleted mutant | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismClinical lung adenocarcinoma tissue (Primary cancer cells, Stage IA) | In-vivo virus concentration1 MOI | In-vivo toxicityNA | In-vivo result100% cancer cell viability | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_98 | Virus nameAdenovirus | Virus strainAdLacZ | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1/E3-deleted mutant | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismClinical lung adenocarcinoma tissue (Primary cancer cells, Stage IA) | In-vivo virus concentration10 MOI | In-vivo toxicityNA | In-vivo result100% cancer cell viability | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_99 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismClinical lung adenocarcinoma tissue (Primary cancer cells, Stage IA) | In-vivo virus concentration0.01 MOI | In-vivo toxicityNA | In-vivo result100% cancer cell viability | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |
IDOV_100 | Virus nameAdenovirus | Virus strainAd5WS1 | Virus genome typeDNA | Virus familyAdenoviridae | Virus genome modificationE1B55K-deleted mutant driven by the E1 promoter | Virus aloneYes | Virus in combination with drug/radiationNo | Immune gene insertion in viral genomeNo | Source of cell lineNA | Origin of cell lineNA | Cell lineNA | Concentration of cell lineNA | In-vitro toxicityNA | AssayNA | In-vitro virus concentrationNA | In-vitro resultNA | Model organismClinical lung adenocarcinoma tissue (Primary cancer cells, Stage IA) | In-vivo virus concentration0.1 MOI | In-vivo toxicityNA | In-vivo result100% cancer cell viability | Mode of deliveryNA | Pathway inducedNA | Immunogenic effectNA | Clinical trialNA | PMID26515462 |