Detailed description page of Selected OV_ID


OV_46 details
Primary information
OV_IDOV_46
Virus Name Adenovirus
StrainAd-cycE
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeE1b-deleted mutant with a human cyclin E promoter driving an intact E1A expression cassette
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineNA
Origin of cell lineNA
Cell lineNA
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismFemale FVB/NCr mice isograft for 5× 10^6 ED-1 murine lung cancer cell lines
In-vivo virus concentration1.5 × 10^9 IFU (on 0, 2, 4 and 6 days)
In-vivo toxicityNA
In-vivo resultReduction in tumor volume to 52 cubic millimeter compared to control 150 cubic millimeter after 36 days
Mode of deliveryIntratumorally
Pathway inductionNA
Immunogenic effectActivates CDK2 and targets the transcriptional repressor pRb
Clinical trialNA
PMID26475304