Browse By Model Organism Result Page of OvirusTdb

The total number of records retrieved from this search are 100. Click on ID to see further detail.
IDOV_897Virus nameHerpes simplex virusVirus strainMutantVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDeletion mutant for Gamma 34.5Virus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for Hep 3B cancer cell lineIn-vivo virus concentration1.0E+7 pfu In-vivo toxicityNA In-vivo resultComplete reduction in tumor nodes after 4 weeksMode of deliveryintraperitonialPathway inducedNAImmunogenic effectNAClinical trialNAPMID12788648
IDOV_916Virus nameHerpes simplex virusVirus strainBaco-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNon- fusogenic ligated with EGFP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/cByJIcrSmnHsd-scid mice orthotopic xenograft for prostate cancer cell lineIn-vivo virus concentration2.0E+7 pfu In-vivo toxicityNA In-vivo result30% reduction in tumor volumeMode of deliveryTail vein injection of virusPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_917Virus nameHerpes simplex virusVirus strainSynco-2Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationFusogenic membrane ligated with GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/cByJIcrSmnHsd-scid mice orthotopic xenograft for prostate cancer cell lineIn-vivo virus concentration2.0E+7 pfu In-vivo toxicityNA In-vivo result50% reduction in tumor volumeMode of deliveryTail vein injection of virusPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_918Virus nameHerpes simplex virusVirus strainSynco-2DVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDouble fusogenic expressing EGFP and GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/cByJIcrSmnHsd-scid mice orthotopic xenograft for prostate cancer cell lineIn-vivo virus concentration2.0E+7 pfu In-vivo toxicityNA In-vivo result60% reduction in tumor volumeMode of deliveryTail vein injection of virusPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_919Virus nameHerpes simplex virusVirus strainBaco-1Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationNon- fusogenic ligated with EGFP proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/cByJIcrSmnHsd-scid mice metastatic lung metastatic modelIn-vivo virus concentration2.0E+7 pfu In-vivo toxicityNA In-vivo resultLung metastasis were not detected after 40 days when stained with bouins fixativeMode of deliveryTail vein injection of virusPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_920Virus nameHerpes simplex virusVirus strainSynco-2Virus genome typeDNAVirus familyHerpesviridaeVirus genome modificationFusogenic membrane ligated with GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/cByJIcrSmnHsd-scid mice metastatic lung metastatic modelIn-vivo virus concentration2.0E+7 pfu In-vivo toxicityNA In-vivo resultLung metastasis were not detected after 40 days when stained with bouins fixativeMode of deliveryTail vein injection of virusPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_921Virus nameHerpes simplex virusVirus strainSynco-2DVirus genome typeDNAVirus familyHerpesviridaeVirus genome modificationDouble fusogenic expressing EGFP and GALV.fus proteinVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismBALB/cByJIcrSmnHsd-scid mice metastatic lung metastatic modelIn-vivo virus concentration2.0E+7 pfu In-vivo toxicityNA In-vivo resultLung metastasis were not detected after 40 days when stained with bouins fixativeMode of deliveryTail vein injection of virusPathway inducedNAImmunogenic effectNAClinical trialNAPMID15129429
IDOV_1915Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineMalignan small cell canine carcinoma cell lineCell lineMTH52cConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for MTH52c cell lineIn-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultSignificant decrease in tumor volume after 42 daysMode of deliveryNAPathway inducedNAImmunogenic effectVirus cause increase expression of ApoA1, IL-2,11,18,IFN-gamma, IP-10, MCP-1,3,5,MIP-2,MMP-9 and TNF alphaClinical trialNAPMID20631910
IDOV_2063Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell linePLCConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismAthymic hsd nude mice xenograft for PLC cell lineIn-vivo virus concentration5.0E+6 pfuIn-vivo toxicityReduction in tumor volume below 2000mm compared to control after 45 days In-vivo resultNo responseMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2064Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman hepatocellular carcinoma cell lineCell lineHuh-7Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismAthymic hsd nude mice xenograft for PLC cell lineIn-vivo virus concentration5.0E+6 pfuIn-vivo toxicityReduction in tumor volume below 3000mm compared to control after 35 days In-vivo resultMode of deliveryNAPathway inducedInduction of apoptosis in cancer cell lineImmunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2Clinical trialNAPMID21779374
IDOV_2526Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd:athymic nude mice xenografted for PANC-1 cell line(2.0E+6 cells)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultDecrease in tumor volume below 2 after 34 daysMode of deliveryIntratumoralPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2527Virus nameVaccinia virusVirus strainGLV-1h151Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDeteltion of TK gene and addition of GFP geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman pancreatic cancer cell lineCell linePANC-1Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd:athymic nude mice xenografted for PANC-1 cell line(2.0E+6 cells)In-vivo virus concentration2.0E+6 pfuIn-vivo toxicityNA In-vivo resultDecrease in tumor volume below 2 after 34 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID22258815
IDOV_2843Virus nameVaccinia virusVirus strainwild typeVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationNoneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-116Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd:athymic nude mice xenograft for HCT-116 (5.0E+6 cells)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultSignificant reduction in tumor volume after 42 daysMode of deliveryIntratumoralPathway inducedNAImmunogenic effectNAClinical trialNAPMID23531320
IDOV_3002Virus namePoxvirusVirus strainCF33-hNISVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of gene encoding human hNISVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-116Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd:athymic nude mice xenograft for HCT-116 (2.0E+6 cells)In-vivo virus concentration1.0E+5 pfuIn-vivo toxicityNA In-vivo resultComplete regression in tumor volume after 55 daysMode of deliveryIntratumoralPathway inducedImmunogenicity followed by virus induced cell deathImmunogenic effectNAClinical trialNAPMID31061881
IDOV_3003Virus namePoxvirusVirus strainCF33-hNISVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of gene encoding human hNISVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHT-29Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd:athymic nude mice xenograft for HT-29 (5.0E+6 cells)In-vivo virus concentration1.0E+5 pfuIn-vivo toxicityNA In-vivo resultTumor volume reached 1500mm after day 50Mode of deliveryIntratumoralPathway inducedImmunogenicity followed by virus induced cell deathImmunogenic effectNAClinical trialNAPMID31061881
IDOV_3004Virus namePoxvirusVirus strainCF33-hNISVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of gene encoding human hNISVirus aloneNoVirus in combination with drug/radiationVirus in combination with I-131Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHCT-116Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd:athymic nude mice xenograft for HCT-116 (2.0E+6 cells)In-vivo virus concentration1.0E+4 pfuIn-vivo toxicityNA In-vivo resultReduction in tumor volume below 100mm after 55 daysMode of deliveryIntravenousPathway inducedImmunogenicity followed by virus induced cell deathImmunogenic effectNAClinical trialNAPMID31061881
IDOV_3005Virus namePoxvirusVirus strainCF33-hNISVirus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of gene encoding human hNISVirus aloneNoVirus in combination with drug/radiationVirus in combination with I-131Immune gene insertion in viral genomeNoSource of cell lineATCCOrigin of cell lineHuman colorectal cancer cell lineCell lineHT-29Concentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd:athymic nude mice xenograft for HT-29 (3.0E+9 cells)In-vivo virus concentration1.0E+4 pfuIn-vivo toxicityNA In-vivo resultReduction in tumor volume below 300mm after 45 daysMode of deliveryIntravenousPathway inducedImmunogenicity followed by virus induced cell deathImmunogenic effectNAClinical trialNAPMID31061881
IDOV_4108Virus nameVaccinia virusVirus strainVVstrain LIVP 6.1.1Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationMutant for J2R geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineUniversity of colorado, USAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for STSA-1 cell line (1.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 1000 mm compared to control 2500mm after 42 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID26205404
IDOV_4109Virus nameVaccinia virusVirus strainVVstrain GLV-5b451Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationDerived from LIVP6.1.1 by inserting glaf-2 gene into J2R locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineUniversity of colorado, USAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for STSA-1 cell line (1.0E+6)In-vivo virus concentration1.0E+7 pfuIn-vivo toxicityNA In-vivo resultTumor volume reduced to 200 mm compared to control 2500mm after 49 daysMode of deliveryIntravenousPathway inducedNAImmunogenic effectNAClinical trialNAPMID26205404
IDOV_5682Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 261.8mm compared to control 240.8 mm after 33 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5683Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 248.4mm compared to control 240.8 mm after 33 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5684Virus nameVaccinia virusVirus strainGLV-1h70Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 216.8mm compared to control 240.8 mm after 33 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5685Virus nameVaccinia virusVirus strainGLV-1h71Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 208.8mm compared to control 240.8 mm after 33 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5686Virus nameVaccinia virusVirus strainGLV-1h72Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA and LacZ at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 157.2mm compared to control 240.8 mm after 33 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5687Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 280.3mm compared to control 240.8 mm after 33 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5688Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 301.9mm compared to control 240.8 mm after 33 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5689Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 273.5mm compared to control 263.6 mm after 36 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5690Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 243.8mm compared to control 263.6 mm after 36 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5691Virus nameVaccinia virusVirus strainGLV-1h70Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 286mm compared to control 263.6 mm after 36 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5692Virus nameVaccinia virusVirus strainGLV-1h71Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 267.1mm compared to control 263.6 mm after 36 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5693Virus nameVaccinia virusVirus strainGLV-1h72Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA and LacZ at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 155.6mm compared to control 263.6 mm after 36 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5694Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 310.9mm compared to control 263.6 mm after 36 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5695Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 416.9mm compared to control 263.6 mm after 36 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5696Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 536.1mm compared to control 579.1 mm after 43 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5697Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 5550.4mm compared to control 579.1 mm after 43 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5698Virus nameVaccinia virusVirus strainGLV-1h70Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 463.4mm compared to control 579.1 mm after 43 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5699Virus nameVaccinia virusVirus strainGLV-1h71Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 543.3mm compared to control 579.1 mm after 43 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5700Virus nameVaccinia virusVirus strainGLV-1h72Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA and LacZ at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 320.1mm compared to control 579.1 mm after 43 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5701Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 679mm compared to control 579.1 mm after 43 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5702Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 660mm compared to control 579.1 mm after 43 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5703Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 701.4mm compared to control 636.4 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5704Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 761.3mm compared to control 636.4 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5705Virus nameVaccinia virusVirus strainGLV-1h70Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 706.6mm compared to control 636.4 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5706Virus nameVaccinia virusVirus strainGLV-1h71Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 721.3mm compared to control 636.4 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5707Virus nameVaccinia virusVirus strainGLV-1h72Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA and LacZ at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 476.3mm compared to control 636.4 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5708Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 864.1mm compared to control 636.4 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5709Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 828.6mm compared to control 636.4 mm after 50 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5710Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 978.4mm compared to control 671.6 mm after 57 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5711Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 852mm compared to control 671.6 mm after 57 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5712Virus nameVaccinia virusVirus strainGLV-1h70Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 985.5mm compared to control 671.6 mm after 57 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5713Virus nameVaccinia virusVirus strainGLV-1h71Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 936.1mm compared to control 671.6 mm after 57 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5714Virus nameVaccinia virusVirus strainGLV-1h72Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA and LacZ at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 695mm compared to control 671.6 mm after 57 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5715Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 1179.9mm compared to control 671.6 mm after 57 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5716Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 897.4mm compared to control 671.6 mm after 57 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5717Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 1485mm compared to control 2715 mm after 92 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5718Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 1053mm compared to control 2715 mm after 92 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5719Virus nameVaccinia virusVirus strainGLV-1h70Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 852mm compared to control 2715 mm after 92 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5720Virus nameVaccinia virusVirus strainGLV-1h71Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 606mm compared to control 2715 mm after 92 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5721Virus nameVaccinia virusVirus strainGLV-1h72Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA and LacZ at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 751mm compared to control 2715 mm after 92 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5722Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 166.7mm compared to control 2715 mm after 92 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5723Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultComplete regression in tumor volume after 92 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5724Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 1536.9mm compared to control 2918.3 mm after 97 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5725Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 962.2mm compared to control 2918.3 mm after 97 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5726Virus nameVaccinia virusVirus strainGLV-1h70Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, LacZ gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 579.2mm compared to control 2918.3 mm after 97 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5727Virus nameVaccinia virusVirus strainGLV-1h71Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 546.9mm compared to control 2918.3 mm after 97 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5728Virus nameVaccinia virusVirus strainGLV-1h72Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA and LacZ at F14.5L gene locus and TK and HA gene locus respectively using P11k vectorVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 720.1mm compared to control 2918.3 mm after 97 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5729Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume become 117.8mm compared to control 2918.3 mm after 97 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5730Virus nameVaccinia virusVirus strainGLV-1h74Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, noncoding DNA at TK locus and HA gene locus in gusAVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultComplete regression in tumor volume after 97 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5731Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 412.9mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5732Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 350.2mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5733Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 341.1mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5734Virus nameVaccinia virusVirus strainGLV-1h82Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 353.4mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5735Virus nameVaccinia virusVirus strainGLV-1h83Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 392.25mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5736Virus nameVaccinia virusVirus strainGLV-1h84Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of F14.5L gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 305.6mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5737Virus nameVaccinia virusVirus strainGLV-1h85Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA into F14.5L gene, TK gene at place of LacZ and gusA gene at place of HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 350.65mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5738Virus nameVaccinia virusVirus strainGLV-1h86Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP into F14.5L gene, noncoding DNA at place of LacZ and HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 419.55mm after 39 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5739Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 750.4mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5740Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 722.3mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5741Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 819.8mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5742Virus nameVaccinia virusVirus strainGLV-1h82Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1081.2mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5743Virus nameVaccinia virusVirus strainGLV-1h83Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1222.25mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5744Virus nameVaccinia virusVirus strainGLV-1h84Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of F14.5L gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 604.3mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5745Virus nameVaccinia virusVirus strainGLV-1h85Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA into F14.5L gene, TK gene at place of LacZ and gusA gene at place of HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 914mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5746Virus nameVaccinia virusVirus strainGLV-1h86Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP into F14.5L gene, noncoding DNA at place of LacZ and HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 962.1mm after 47 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5747Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1424.4mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5748Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1390.35mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5749Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 983.2mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5750Virus nameVaccinia virusVirus strainGLV-1h82Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1319.2mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5751Virus nameVaccinia virusVirus strainGLV-1h83Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1686.05mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5752Virus nameVaccinia virusVirus strainGLV-1h84Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of F14.5L gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 982mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5753Virus nameVaccinia virusVirus strainGLV-1h85Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA into F14.5L gene, TK gene at place of LacZ and gusA gene at place of HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 947.2mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5754Virus nameVaccinia virusVirus strainGLV-1h86Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP into F14.5L gene, noncoding DNA at place of LacZ and HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1397.55mm after 62 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5755Virus nameVaccinia virusVirus strainGLV-1h22Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1907.5mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5756Virus nameVaccinia virusVirus strainGLV-1h68Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP, non coding DNA at F14.5L gene locus and TK and HA gene locus using psel vectorrespectivelyVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1528.95mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5757Virus nameVaccinia virusVirus strainGLV-1h73Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locusVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 517.3mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5758Virus nameVaccinia virusVirus strainGLV-1h82Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1211.8mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5759Virus nameVaccinia virusVirus strainGLV-1h83Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of HA gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 1856.35mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5760Virus nameVaccinia virusVirus strainGLV-1h84Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP gene at place of F14.5L gene under Psel promoterVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 614.25mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5761Virus nameVaccinia virusVirus strainGLV-1h85Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of noncoding DNA into F14.5L gene, TK gene at place of LacZ and gusA gene at place of HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 255.25mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968
IDOV_5762Virus nameVaccinia virusVirus strainGLV-1h86Virus genome typeDNAVirus familyPoxviridaeVirus genome modificationInsertion of Ruc-GFP into F14.5L gene, noncoding DNA at place of LacZ and HA geneVirus aloneYesVirus in combination with drug/radiationNoImmune gene insertion in viral genomeNoSource of cell lineNAOrigin of cell lineNACell lineNAConcentration of cell lineNAIn-vitro toxicityNAAssayNAIn-vitro virus concentrationNAIn-vitro resultNAModel organismHsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5.0E+6)In-vivo virus concentration5.0E+6 pfuIn-vivo toxicityNA In-vivo resultTumor volume becomes 689.6mm after 75 daysMode of deliveryIntravenouslyPathway inducedInduction of apoptosisImmunogenic effectNAClinical trialNAPMIDUS8052968