| Primary information |
|---|
| OV_ID | OV_5701 |
| Virus Name | Vaccinia virus |
| Strain | GLV-1h73 |
| Virus type | DNA |
| Virus family | Poxviridae |
| Modification in virus genome | Insertion of noncoding DNA at F14.5 locus, LacZ gene at TK gene, noncoding DNA into HA locus |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | No |
| Source of cell line | NA |
| Origin of cell line | NA |
| Cell line | NA |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | Hsd athymic nude mice xenograft for GI-101A human breast carcinoma cells (5 ×10â¶) |
| In-vivo virus concentration | 5 ×10ⶠpfu |
| In-vivo toxicity | NA |
| In-vivo result | Tumor volume become 679mm compared to control 579.1 mm after 43 days |
| Mode of delivery | Intravenously |
| Pathway induction | Induction of apoptosis |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | US8052968 |