Please click on the ID to see detailed information about each entry.
The total number entries retrieved from this search are| ID1143 | Sequencer–nle–nle–nle–r–nle–nle–nle–g–y | NameRDP58 | Nature of peptide or cargoImmunomodulator | AssayHistological assay using bright field microscopy | Tissue permeabilityIt can be clearly seen from the histological images that topical application of RDP58results in significant decrease in tthe hickness of the ear skin as compared to control (TPA applied ear skin) | Tissue SampleEar of mice | PUBMED ID16117788 |
| ID1283 | SequenceHSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | NameStearyl-Nle17- VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of number of cups | Tissue permeabilityMeasurement of number of first cup: Control:7 minutes , Test:20.2 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1284 | SequenceHSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | NameStearyl-Nle17- VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of E2(Erection) | Tissue permeabilityMeasurement of number of first E2(Erection): Control:11 minutes , Test:35 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1285 | SequenceHSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | NameStearyl-Nle17- VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of latency of first cup | Tissue permeabilityMeasurement of latency of first cup: Control:23 minutes , Test:10 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1286 | SequenceHSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | NameStearyl-Nle17- VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay, Measurement of latency of first E2(Erection) | Tissue permeabilityMeasurement of latency of first E2(Erection): Control:3.5 minutes , Test:1.9 minutes | Tissue SampleIn castrated testosterone treated rats | PUBMED ID8156912 |
| ID1287 | SequenceHSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | NameStearyl-Nle17- VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay | Tissue permeabilityTime course of distribution of radioactively labelled peptide: Control:6 minutes , Test:20 minutes | Tissue SampleThree-month-old diabetic rats | PUBMED ID8156912 |
| ID1288 | SequenceHSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | NameStearyl-Nle17- VIP | Nature of peptide or cargoA key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | AssayRadioactive assay | Tissue permeabilityTime course of distribution of radioactively labelled peptide:Control:5.5 minutes , Test:21.5 minutes | Tissue SampleSpontaneous high blood pressure rats(SHR) | PUBMED ID8156912 |
| ID1302 | SequenceSYS-Nle-EHfRWGKPV | Name[Nle4, D-Phe7]-alpha-MSH | Nature of peptide or cargoThe analogue is superpotent, being 10- 1000 times more active than the native hormone | AssayLight and electron microscopy | Tissue permeability10-7 to 10-12 concentrations turned yellow hair brown | Tissue SampleMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect | PUBMED ID3684299 |
| ID1303 | SequenceNle-EHfRWGK | Name[Nle4, D-Phe7]-alpha-MSH4-11 | Nature of peptide or cargoNot mentioned | AssayLight and electron microscopy | Tissue permeability10-8 to 10-14 concentrations turned yellow hair brown | Tissue SampleMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect | PUBMED ID3684299 |
| ID1304 | SequenceNle-EHfRWG | Name[Nle4, D-Phe7]-alpha-MSH4-10 | Nature of peptide or cargoNot mentioned | AssayLight and electron microscopy | Tissue permeability10-8 to 10-14 concentrations turned yellow hair brown | Tissue SampleMelanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect | PUBMED ID3684299 |
| ID1306 | SequenceSYS-Nle-EHfRWGKPV | Name(Nle4, D-Phe7]-α-MSH | Nature of peptide or cargothe melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of mice | AssayElectron microscopy and Light microscopy | Tissue permeabilityConcentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application. | Tissue Sampledorsal trunk of mice (C57BL/6JA y) | PUBMED ID3624899 |
| ID1307 | SequenceNle-EHfFRWGK | NameAc-[Nle4, D-Phe7]-α- MSH4–11-NH2 | Nature of peptide or cargothe melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of mice | AssayElectron microscopy and Light microscopy | Tissue permeabilityConcentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application. | Tissue Sampledorsal trunk of mice (C57BL/6JA y) | PUBMED ID3624899 |
| ID1308 | SequenceNle-EH-FRWG | NameAc-[Nle4, D-Phe7]-α-MSH4–10-NH2 | Nature of peptide or cargothe melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of mice | AssayElectron microscopy and Light microscopy | Tissue permeabilityConcentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application. | Tissue Sampledorsal trunk of mice (C57BL/6JA y) | PUBMED ID3624899 |
| ID1310 | SequenceSYS-Nle-EHfRWGKPV | Name(Nle4, D-Phe7)-a-MSH | Nature of peptide or cargoThe analogue is superpotent, being 10- 1000 times more active than the native hormone | AssayElectron microscopic examination | Tissue permeabilityMinimal effective dose=10-12M. It is transdermally delivered systemically to hair follicles throughout the body to induce follicular melanogenesis. Microscopic examination revealed eumelanin within hair bulbs by 24 hours after topical application of the analogue. | Tissue SamplePosterior dorsum of mice (C57BL/6JA y) | PUBMED ID3573985 |
| ID1311 | SequenceSYS-Nle-EHfRWGKPV | Name[Nle4, D-Phe7]-alpha-MSH | Nature of peptide or cargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | AssayFrog Skin Bioassay | Tissue permeabilityPercent positive samples of transdermal delivery :65% (15/23) | Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation | PUBMED ID2845208 |
| ID1312 | SequenceSYS-Nle-EHfRWGKPV | Name[Nle4, D-Phe7]-alpha-MSH | Nature of peptide or cargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | AssayRadioimmunoassay | Tissue permeabilityPercent positive samples of transdermal delivery :85% (11/13) | Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation | PUBMED ID2845208 |
| ID1313 | SequenceSYS-Nle-EHfRWGKPV | Name[Nle4, D-Phe7]-alpha-MSH | Nature of peptide or cargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | AssayFrog Skin Bioassay | Tissue permeabilityPercent positive samples of transdermal delivery :6.6% (1/15) | Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of mature Sprague Dawley rats. | PUBMED ID2845208 |
| ID1314 | SequenceSYS-Nle-EHfRWGKPV | Name[Nle4, D-Phe7]-alpha-MSH | Nature of peptide or cargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | AssayRadioimmunoassay | Tissue permeabilityPercent positive samples of transdermal delivery :11.8% (2/17) | Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of mature Sprague Dawley rats. | PUBMED ID2845208 |
| ID1315 | SequenceSYS-Nle-EHfRWGKPV | Name[Nle4, D-Phe7]-alpha-MSH | Nature of peptide or cargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | AssayFrog Skin Bioassay, radioimmunoassay and microscopy | Tissue permeabilityTransdermal delivery of 0.05% | Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation | PUBMED ID2845208 |
| ID1316 | SequenceSYS-Nle-EHfRWGKPV | Name[Nle4, D-Phe7]-alpha-MSH | Nature of peptide or cargoA superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | AssayFrog Skin Bioassay, radioimmunoassay and microscopy | Tissue permeabilityTransdermal delivery of 0.08% | Tissue SampleFull thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation | PUBMED ID2845208 |
| ID1333 | SequenceSYS-Nle-EHfRWGKPV | Name(Nle4, D-Phe7)-a-MSH | Nature of peptide or cargoThe analogue is superpotent, being 10- 1000 times more active than the native hormone, a-MSH, in several bioassays | AssayFrog Skin Bioassay | Tissue permeabilityHead and neck(85.7%), Trunk(8.7%),Leg(25%) | Tissue SampleStratum corneum of human skin samples (obtained from freshly excised surgical specimens) | PUBMED ID2155969 |
| ID1334 | SequenceSYS-Nle-EHfRWGKPV | Name(Nle4, D-Phe7)-a-MSH | Nature of peptide or cargoThe analogue is superpotent, being 10- 1000 times more active than the native hormone, a-MSH, in several bioassays | AssayRadioimmunoassay | Tissue permeabilityHead and neck(78.6%), Trunk(8.8%),Leg(33.3%) | Tissue SampleStratum corneum of human skin samples (obtained from freshly excised surgical specimens) | PUBMED ID2155969 |