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The total number entries retrieved from this search are| ID | Sequence | Name | Nature of peptide or cargo | Assay | Tissue permeability | Tissue Sample | PUBMED ID |
|---|---|---|---|---|---|---|---|
| 1143 | r–nle–nle–nle–r–nle–nle–nle–g–y | RDP58 | Immunomodulator | Histological assay using bright field microscopy | It can be clearly seen from the histological images that topical application of RDP58results in significant decrease in tthe hickness of the ear skin as compared to control (TPA applied ear skin) | Ear of mice | 16117788 |
| 1283 | HSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | Stearyl-Nle17- VIP | A key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | Radioactive assay, Measurement of number of cups | Measurement of number of first cup: Control:7 minutes , Test:20.2 minutes | In castrated testosterone treated rats | 8156912 |
| 1284 | HSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | Stearyl-Nle17- VIP | A key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | Radioactive assay, Measurement of E2(Erection) | Measurement of number of first E2(Erection): Control:11 minutes , Test:35 minutes | In castrated testosterone treated rats | 8156912 |
| 1285 | HSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | Stearyl-Nle17- VIP | A key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | Radioactive assay, Measurement of latency of first cup | Measurement of latency of first cup: Control:23 minutes , Test:10 minutes | In castrated testosterone treated rats | 8156912 |
| 1286 | HSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | Stearyl-Nle17- VIP | A key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | Radioactive assay, Measurement of latency of first E2(Erection) | Measurement of latency of first E2(Erection): Control:3.5 minutes , Test:1.9 minutes | In castrated testosterone treated rats | 8156912 |
| 1287 | HSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | Stearyl-Nle17- VIP | A key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | Radioactive assay | Time course of distribution of radioactively labelled peptide: Control:6 minutes , Test:20 minutes | Three-month-old diabetic rats | 8156912 |
| 1288 | HSDAVFTDNYTRLR KQ-Nle-AVKKYLNSILN | Stearyl-Nle17- VIP | A key penile neurotransmitter, induces erection after local injection in man. Significantly increased sexual function as measured by copulatory activity and penile reflexes(erections) in testosterone-treated, castrated rats. | Radioactive assay | Time course of distribution of radioactively labelled peptide:Control:5.5 minutes , Test:21.5 minutes | Spontaneous high blood pressure rats(SHR) | 8156912 |
| 1302 | SYS-Nle-EHfRWGKPV | [Nle4, D-Phe7]-alpha-MSH | The analogue is superpotent, being 10- 1000 times more active than the native hormone | Light and electron microscopy | 10-7 to 10-12 concentrations turned yellow hair brown | Melanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect | 3684299 |
| 1303 | Nle-EHfRWGK | [Nle4, D-Phe7]-alpha-MSH4-11 | Not mentioned | Light and electron microscopy | 10-8 to 10-14 concentrations turned yellow hair brown | Melanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect | 3684299 |
| 1304 | Nle-EHfRWG | [Nle4, D-Phe7]-alpha-MSH4-10 | Not mentioned | Light and electron microscopy | 10-8 to 10-14 concentrations turned yellow hair brown | Melanotropin dose was applied on the shaved skin of C57BL/6AY mice which stimulated the yellow hair to turn yellow which was observed at other untouched areas proving systemic effect | 3684299 |
| 1306 | SYS-Nle-EHfRWGKPV | (Nle4, D-Phe7]-α-MSH | the melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of mice | Electron microscopy and Light microscopy | Concentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application. | dorsal trunk of mice (C57BL/6JA y) | 3624899 |
| 1307 | Nle-EHfFRWGK | Ac-[Nle4, D-Phe7]-α- MSH4–11-NH2 | the melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of mice | Electron microscopy and Light microscopy | Concentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application. | dorsal trunk of mice (C57BL/6JA y) | 3624899 |
| 1308 | Nle-EH-FRWG | Ac-[Nle4, D-Phe7]-α-MSH4–10-NH2 | the melanotropin analogs stimulated follicular eumelanogenesis when applied topically to the skin of mice | Electron microscopy and Light microscopy | Concentrations (10-7 M-10-15 M) induced the emergent hairs to become brown at the sites of application. | dorsal trunk of mice (C57BL/6JA y) | 3624899 |
| 1310 | SYS-Nle-EHfRWGKPV | (Nle4, D-Phe7)-a-MSH | The analogue is superpotent, being 10- 1000 times more active than the native hormone | Electron microscopic examination | Minimal effective dose=10-12M. It is transdermally delivered systemically to hair follicles throughout the body to induce follicular melanogenesis. Microscopic examination revealed eumelanin within hair bulbs by 24 hours after topical application of the analogue. | Posterior dorsum of mice (C57BL/6JA y) | 3573985 |
| 1311 | SYS-Nle-EHfRWGKPV | [Nle4, D-Phe7]-alpha-MSH | A superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | Frog Skin Bioassay | Percent positive samples of transdermal delivery :65% (15/23) | Full thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation | 2845208 |
| 1312 | SYS-Nle-EHfRWGKPV | [Nle4, D-Phe7]-alpha-MSH | A superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | Radioimmunoassay | Percent positive samples of transdermal delivery :85% (11/13) | Full thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation | 2845208 |
| 1313 | SYS-Nle-EHfRWGKPV | [Nle4, D-Phe7]-alpha-MSH | A superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | Frog Skin Bioassay | Percent positive samples of transdermal delivery :6.6% (1/15) | Full thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of mature Sprague Dawley rats. | 2845208 |
| 1314 | SYS-Nle-EHfRWGKPV | [Nle4, D-Phe7]-alpha-MSH | A superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | Radioimmunoassay | Percent positive samples of transdermal delivery :11.8% (2/17) | Full thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of mature Sprague Dawley rats. | 2845208 |
| 1315 | SYS-Nle-EHfRWGKPV | [Nle4, D-Phe7]-alpha-MSH | A superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | Frog Skin Bioassay, radioimmunoassay and microscopy | Transdermal delivery of 0.05% | Full thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation | 2845208 |
| 1316 | SYS-Nle-EHfRWGKPV | [Nle4, D-Phe7]-alpha-MSH | A superpotent(10-1000 times) analogue of alpha-melanocyte stimulating hormone, it causes a very long lasting stimulation of melanocytes in vitro and in vivo, its nonbiodegradeable and it is resistant to enzymatic inactivation by sera, brain enzymes or purified proteolytic enzymes. | Frog Skin Bioassay, radioimmunoassay and microscopy | Transdermal delivery of 0.08% | Full thickness skin samples (approximately 1 and a half" in diameter) were removed from the trunk area of either black or yellow adult C57BL/6JAy mice killed by cervical dislocation | 2845208 |
| 1333 | SYS-Nle-EHfRWGKPV | (Nle4, D-Phe7)-a-MSH | The analogue is superpotent, being 10- 1000 times more active than the native hormone, a-MSH, in several bioassays | Frog Skin Bioassay | Head and neck(85.7%), Trunk(8.7%),Leg(25%) | Stratum corneum of human skin samples (obtained from freshly excised surgical specimens) | 2155969 |
| 1334 | SYS-Nle-EHfRWGKPV | (Nle4, D-Phe7)-a-MSH | The analogue is superpotent, being 10- 1000 times more active than the native hormone, a-MSH, in several bioassays | Radioimmunoassay | Head and neck(78.6%), Trunk(8.8%),Leg(33.3%) | Stratum corneum of human skin samples (obtained from freshly excised surgical specimens) | 2155969 |