Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0429BV-nucleic acid

Click for more detail

Baculovirus(virus)NANANucleic AcidNaturalIt leads to increased expression of cytokine IL-12 p40Toll-like receptor 21 (TLR21)Toll-like receptor (TLR)ChickenMacrophage-like cell line (HD11)Leucine-rich Repeat (LRR) DomainNANANAThis results into the inflammatory response, which leads to clearance of pathogenNA204711862010NA
PRRID_0429BV-nucleic acid

Click for more detail

Baculovirus(virus)NANANucleic AcidNaturalIt leads to increased expression of cytokine IL-12 p40Toll-like receptor 21 (TLR21)Toll-like receptor (TLR)ChickenMacrophage-like cell line (HD11)Leucine-rich Repeat (LRR) DomainNANANAThis results into the inflammatory response, which leads to clearance of pathogenNA204711862010NA
PRRID_0444CpG DNA motifs

Click for more detail

Virus, BacteriaNANANucleic AcidNaturalNAToll-like receptor 21 (TLR21)Toll-like receptor (TLR)ChickenNALeucine-rich Repeat (LRR) DomainNANANAInflammationNA206922892010NA
PRRID_0444CpG DNA motifs

Click for more detail

Virus, BacteriaNANANucleic AcidNaturalNAToll-like receptor 21 (TLR21)Toll-like receptor (TLR)ChickenNALeucine-rich Repeat (LRR) DomainNANANAInflammationNA206922892010NA
PRRID_0534genomic DNA

Click for more detail

Salmonella enterica (Bacteria)NANANucleic AcidNaturalThe binding leads to the activation of the NF-chToll-like receptor 21 (TLR21)Toll-like receptor (TLR)ChickenHD11 macrophageLeucine-rich Repeat (LRR) DomainNANANAIt leads to the inflammatory response from the immune system leads to the clearance of pathogensLuciferase assay204983582010NA
PRRID_0534genomic DNA

Click for more detail

Salmonella enterica (Bacteria)NANANucleic AcidNaturalThe binding leads to the activation of the NF-chToll-like receptor 21 (TLR21)Toll-like receptor (TLR)ChickenHD11 macrophageLeucine-rich Repeat (LRR) DomainNANANAIt leads to the inflammatory response from the immune system leads to the clearance of pathogensLuciferase assay204983582010NA
PRRID_0752poly-UG dsRNA

Click for more detail

BacteriaNANANucleic AcidSyntheticproduction of IFN-⍺, IL-6 and IL-1βToll-like receptor 3 (TLR3)/Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)ChickenSpleenocytesLeucine-rich Repeat (LRR) DomainNANANAImmunostimulation and inflammationNA206922892010NA
PRRID_0752poly-UG dsRNA

Click for more detail

BacteriaNANANucleic AcidSyntheticproduction of IFN-⍺, IL-6 and IL-1βToll-like receptor 3 (TLR3)/Toll-like receptor 7 (TLR7)Toll-like receptor (TLR)ChickenSpleenocytesLeucine-rich Repeat (LRR) DomainNANANAImmunostimulation and inflammationNA206922892010NA
PRRID_0761polyinosinic-polycytidylic acid [poly(I:C)]

Click for more detail

NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticIt results into the induction of type I IFNsToll-like receptor 3 (TLR3)Toll-like receptor (TLR)ChickenSpleenocytesLeucine-rich Repeat (LRR) DomainD6R3C9.fastaD6R3C966ImmunostimulationNA206922892010Pubchem Assay
PRRID_0761polyinosinic-polycytidylic acid [poly(I:C)]

Click for more detail

NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticIt results into the induction of type I IFNsToll-like receptor 3 (TLR3)Toll-like receptor (TLR)ChickenSpleenocytesLeucine-rich Repeat (LRR) DomainD6R3C9.fastaD6R3C966ImmunostimulationNA206922892010Pubchem Assay
PRRID_0828Unmethylated CpG DNA

Click for more detail

BacteriaNANANucleic AcidSyntheticThe binding leads to the activation of the NF-chToll-like receptor 21 (TLR21)Toll-like receptor (TLR)ChickenHD11 macrophageLeucine-rich Repeat (LRR) DomainNANANAIt leads to the inflammatory response from the immune system leads to the clearance of pathogensLuciferase assay204983582010NA
PRRID_0828Unmethylated CpG DNA

Click for more detail

BacteriaNANANucleic AcidSyntheticThe binding leads to the activation of the NF-chToll-like receptor 21 (TLR21)Toll-like receptor (TLR)ChickenHD11 macrophageLeucine-rich Repeat (LRR) DomainNANANAIt leads to the inflammatory response from the immune system leads to the clearance of pathogensLuciferase assay204983582010NA
PRRID_0829Unmethylated CpG DNA

Click for more detail

BacteriaNANANucleic AcidSyntheticIt leads to increased expression of cytokine IL-12 p41Toll-like receptor 21 (TLR2)Toll-like receptor (TLR)ChickenMacrophage-like cell line (HD11)Leucine-rich Repeat (LRR) DomainNANANAThis results into the inflammatory response.NA204711862010NA
PRRID_0829Unmethylated CpG DNA

Click for more detail

BacteriaNANANucleic AcidSyntheticIt leads to increased expression of cytokine IL-12 p41Toll-like receptor 21 (TLR2)Toll-like receptor (TLR)ChickenMacrophage-like cell line (HD11)Leucine-rich Repeat (LRR) DomainNANANAThis results into the inflammatory response.NA204711862010NA
PRRID_1210class B CpG DNA motifs

Click for more detail

BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 21 (TLR2)Toll-like receptor (TLR)ChickenMacrophagesCell Compartment/Intracellular (ER compartment)H9BPA7.fastaH9BPA7972TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune responseELISA247978932014Pubchem_assay
PRRID_1210class B CpG DNA motifs

Click for more detail

BacteriaNANANucleic AcidSyntheticact as immuno stimulantsToll-like receptor 21 (TLR2)Toll-like receptor (TLR)ChickenMacrophagesCell Compartment/Intracellular (ER compartment)H9BPA7.fastaH9BPA7972TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune responseELISA247978932014Pubchem_assay
PRRID_1249dsRNA

Click for more detail

VirusNANANucleic AcidNaturaltriggers immune responsesToll-like receptor 3 (TLR3)Toll-like receptor (TLR)ChickenDendritic Cell, B-lymphocytecell compartmentQ0PQ88.fastaQ0PQ88896TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune responseELISA247978932014Pubchem_assay
PRRID_1249dsRNA

Click for more detail

VirusNANANucleic AcidNaturaltriggers immune responsesToll-like receptor 3 (TLR3)Toll-like receptor (TLR)ChickenDendritic Cell, B-lymphocytecell compartmentQ0PQ88.fastaQ0PQ88896TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune responseELISA247978932014Pubchem_assay
PRRID_1280Flagellin

Click for more detail

Salmonella typhimurium(Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Chickensplenocytescell surfaceQ5GR02.fastaQ5GR02862TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-cELISA247977222014Pubchem_assay
PRRID_1280Flagellin

Click for more detail

Salmonella typhimurium(Bacteria)MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR495ProteinNaturaltriggers immune responsesToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Chickensplenocytescell surfaceQ5GR02.fastaQ5GR02862TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-cELISA247977222014Pubchem_assay
PRRID_1409Lipopolysaccharide (LPS)

Click for more detail

Escherichia coli (0111:B4) (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduce inflammationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Chickenmonocyte/macrophagescell surfaceQ7ZTG5.fastaQ7ZTG5843TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune responseELISA247978932014Pubchem_assay
PRRID_1409Lipopolysaccharide (LPS)

Click for more detail

Escherichia coli (0111:B4) (Bacteria)CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalinduce inflammationToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Chickenmonocyte/macrophagescell surfaceQ7ZTG5.fastaQ7ZTG5843TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune responseELISA247978932014Pubchem_assay
PRRID_1446Lipoteichoic Acid (LTA)

Click for more detail

BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Chickensplenocytescell surfaceQ9DD78.fastaQ9DD78793TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-cELISA247977222014Pubchem_assay
PRRID_1446Lipoteichoic Acid (LTA)

Click for more detail

BacteriaC(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Chickensplenocytescell surfaceQ9DD78.fastaQ9DD78793TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-cELISA247977222014Pubchem_assay
PRRID_1527Pam3CSK4

Click for more detail

Salmonella typhimurium(Bacteria)CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONALipopeptidesSynthetictriacylated lipopeptide potent activator of the proinflammatory transcription factor NF-κB.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Chickensplenocytescell surfaceQ9DD78.fastaQ9DD78793TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-cELISA247977222014Pubchem_assay
PRRID_1527Pam3CSK4

Click for more detail

Salmonella typhimurium(Bacteria)CCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONALipopeptidesSynthetictriacylated lipopeptide potent activator of the proinflammatory transcription factor NF-κB.Toll-like receptor 2 (TLR2)Toll-like receptor (TLR)Chickensplenocytescell surfaceQ9DD78.fastaQ9DD78793TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-cELISA247977222014Pubchem_assay
PRRID_1546Peptidoglycan (PGN)

Click for more detail

BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Chickensplenocytescell surfaceQ9DD78.fastaQ9DD78793TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-cELISA247977222014Pubchem_assay
PRRID_1546Peptidoglycan (PGN)

Click for more detail

BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Chickensplenocytescell surfaceQ9DD78.fastaQ9DD78793TLR2 and TLR5 promote cellular activation and the production of cytokines including proinflammatory interleukin (IL)-6, as well as those cytokines that help to initiate and modulate the adaptive immune response, including IL-4, IL-12, and interferon (IFN)-cELISA247977222014Pubchem_assay
PRRID_1567poly I:C +CpG-ODN

Click for more detail

NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONAPattern-associated molecular patterns (PAMPs)Synthetichighly immunostimulatoryNANAChickenNANANANANAhighly immunostimulatory and show synergistic effect in cytokine productionELISA247978932014NA
PRRID_1567poly I:C +CpG-ODN

Click for more detail

NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONAPattern-associated molecular patterns (PAMPs)Synthetichighly immunostimulatoryNANAChickenNANANANANAhighly immunostimulatory and show synergistic effect in cytokine productionELISA247978932014NA
PRRID_1574polyinosinic-polycytidylic acid [poly(I:C)]

Click for more detail

NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticact as a TLR3 agonist and induces protective responses against rapidly growing tumor cellsToll-like receptor 3 (TLR3)Toll-like receptor (TLR)ChickenDendritic Cell, B-lymphocytecell compartmentQ0PQ88.fastaQ0PQ88896TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune responseELISA247978932014Pubchem_assay
PRRID_1574polyinosinic-polycytidylic acid [poly(I:C)]

Click for more detail

NAC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)ONANucleic AcidSyntheticact as a TLR3 agonist and induces protective responses against rapidly growing tumor cellsToll-like receptor 3 (TLR3)Toll-like receptor (TLR)ChickenDendritic Cell, B-lymphocytecell compartmentQ0PQ88.fastaQ0PQ88896TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune responseELISA247978932014Pubchem_assay
PRRID_2231Lipopolysaccharide (LPS)

Click for more detail

BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Chickencytoplasm of basal cells of the epithelium in the isthmus, uterus and vaginaLeucine-rich Repeat (LRR) DomainQ7ZTG5.fastaQ7ZTG5843NANA293306752017Pubchem_assay
PRRID_2231Lipopolysaccharide (LPS)

Click for more detail

BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)NaturalNAToll-like receptor 4 (TLR4)Toll-like receptor (TLR)Chickencytoplasm of basal cells of the epithelium in the isthmus, uterus and vaginaLeucine-rich Repeat (LRR) DomainQ7ZTG5.fastaQ7ZTG5843NANA293306752017Pubchem_assay