Detailed description page of PRRDB2.0

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PRRID_1574 details
Primary information
PRRIDPRRID_1574
Ligand Namepolyinosinic-polycytidylic acid [poly(I:C)]
SourceNA
Sequence of ligandC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O
LengthNA
TypeNucleic Acid
OccurenceSynthetic
Role of Ligandact as a TLR3 agonist and induces protective responses against rapidly growing tumor cells
Name of receptorToll-like receptor 3 (TLR3)
Type of receptorToll-like receptor (TLR)
Source Chicken
LocalizationDendritic Cell, B-lymphocyte
Domaincell compartment
Sequence of ReceptorQ0PQ88.fasta
Swiss prot IDQ0PQ88
Length Of Receptor896
FunctionTLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response
Assay usedELISA
PMID24797893
Year of Publication2014
Pubchem assayPubchem_assay
Primary information
PRRIDPRRID_1574
Ligand Namepolyinosinic-polycytidylic acid [poly(I:C)]
SourceNA
Sequence of ligandC1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O
LengthNA
TypeNucleic Acid
OccurenceSynthetic
Role of Ligandact as a TLR3 agonist and induces protective responses against rapidly growing tumor cells
Name of receptorToll-like receptor 3 (TLR3)
Type of receptorToll-like receptor (TLR)
Source Chicken
LocalizationDendritic Cell, B-lymphocyte
Domaincell compartment
Sequence of ReceptorQ0PQ88.fasta
Swiss prot IDQ0PQ88
Length Of Receptor896
FunctionTLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response
Assay usedELISA
PMID24797893
Year of Publication2014
Pubchem assayPubchem_assay