Primary information |
---|
PRRID | PRRID_1574 |
Ligand Name | polyinosinic-polycytidylic acid [poly(I:C)] |
Source | NA |
Sequence of ligand | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O |
Length | NA |
Type | Nucleic Acid |
Occurence | Synthetic |
Role of Ligand | act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells |
Name of receptor | Toll-like receptor 3 (TLR3) |
Type of receptor | Toll-like receptor (TLR) |
Source | Chicken |
Localization | Dendritic Cell, B-lymphocyte |
Domain | cell compartment |
Sequence of Receptor | Q0PQ88.fasta |
Swiss prot ID | Q0PQ88 |
Length Of Receptor | 896 |
Function | TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response |
Assay used | ELISA |
PMID | 24797893 |
Year of Publication | 2014 |
Pubchem assay | Pubchem_assay |
Primary information |
---|
PRRID | PRRID_1574 |
Ligand Name | polyinosinic-polycytidylic acid [poly(I:C)] |
Source | NA |
Sequence of ligand | C1=CN(C(=O)N=C1N)C2C(C(C(O2)COP(=O)(O)O)O)O.C1=NC(=O)C2=C(N1)N(C=N2)C3C(C(C(O3)COP(=O)(O)O)O)O |
Length | NA |
Type | Nucleic Acid |
Occurence | Synthetic |
Role of Ligand | act as a TLR3 agonist and induces protective responses against rapidly growing tumor cells |
Name of receptor | Toll-like receptor 3 (TLR3) |
Type of receptor | Toll-like receptor (TLR) |
Source | Chicken |
Localization | Dendritic Cell, B-lymphocyte |
Domain | cell compartment |
Sequence of Receptor | Q0PQ88.fasta |
Swiss prot ID | Q0PQ88 |
Length Of Receptor | 896 |
Function | TLRs promote cellular activation and the production of cytokines such as interleukin (IL)-12 and interferon (IFN)-c In the case of antigen presenting cells (APCs), TLR stimulation also promotes the up-regulation of major histocompatibility complex class II (MHC-II) and co- stimulatory molecules including CD80 therefore elicitation of a robust adaptive immune response |
Assay used | ELISA |
PMID | 24797893 |
Year of Publication | 2014 |
Pubchem assay | Pubchem_assay |