Representation of Major Biochemical Pathway categories by the genes in PCMdb


A list of genes in PCMdb that can be classified as "Positive Regulators of molecular function" by the UniProt database is given below.
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Gene Symbol Gene Name # of Entries
SH3BP1SH3-domain binding protein 11
ADORA3adenosine A3 receptor9
ABRactive BCR-related55
ACAP3ArfGAP with coiled-coil, ankyrin repeat and PH domains 31
CHRNA3cholinergic receptor, nicotinic, alpha 3 (neuronal)20
ACRCacrosin1
ACTN2actinin, alpha 240
ACVR1Cactivin A receptor, type IC1
ADRA1Aadrenoceptor alpha 1A31
ADRA2Aadrenoceptor alpha 2A10
ADRA2Badrenoceptor alpha 2B30
ADRA2Cadrenoceptor alpha 2C10
ADAM33ADAM metallopeptidase domain 81
ADAP1ArfGAP with dual PH domains 11
ADAP2ArfGAP with dual PH domains 21
CENTA2ArfGAP with dual PH domains 220
ADCY1adenylate cyclase 1 (brain)30
ADCY2adenylate cyclase 2 (brain)20
ADCY4adenylate cyclase 411
ADCY5adenylate cyclase 510
ADCY8adenylate cyclase 8 (brain)30
ADCY9adenylate cyclase 910
ADD2adducin 2 (beta)41
ADRB1adrenoceptor beta 120
ADRB3adrenoceptor beta 351
AGAP1ArfGAP with GTPase domain, ankyrin repeat and PH domain 11
AGAP2ArfGAP with GTPase domain, ankyrin repeat and PH domain 21
CENTG1ArfGAP with GTPase domain, ankyrin repeat and PH domain 29
AGFG1ArfGAP with FG repeats 11
HRBLArfGAP with FG repeats 29
AGTR1angiotensin II receptor, type 110
AHSA2AHA1, activator of heat shock 90kDa protein ATPase homolog 2 (yeast)9
JUBajuba LIM protein1
AKT1v-akt murine thymoma viral oncogene homolog 19
ALKBH4anaplastic lymphoma receptor tyrosine kinase1
FLIIflightless I homolog (Drosophila)1
ANGangiogenin, ribonuclease, RNase A family, 521
ANK2ankyrin 2, neuronal21
NPR3natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)30
ANKRD27ankyrin repeat domain 27 (VPS9 domain)1
ANXA3annexin A320
APOA1apolipoprotein A-I13
APOA4apolipoprotein A-IV20
ARAFv-raf murine sarcoma 3611 viral oncogene homolog10
ARAP2ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 21
ARFGAP1ADP-ribosylation factor GTPase activating protein 110
ARHGEF7Rho guanine nucleotide exchange factor (GEF) 720
ARHGEF15Rho guanine nucleotide exchange factor (GEF) 1520
ARHGEF19Rho guanine nucleotide exchange factor (GEF) 191
ACVR2Bactivin A receptor, type IIB13
BCL2BCL2-like 10 (apoptosis facilitator)62
BCL2L10BCL2-like 11 (apoptosis facilitator)11
BAMBIBMP and activin membrane-bound inhibitor homolog (Xenopus laevis)9
BCAP31B-cell receptor-associated protein 3110
BAXBCL2-associated X protein13
BAZ1Bbromodomain adjacent to zinc finger domain, 1B9
BCL10B-cell CLL/lymphoma 109
BCL2L2B-cell CLL/lymphoma 21
BCRbreakpoint cluster region13
BMI1BMI1 polycomb ring finger oncogene9
BMP4bone morphogenetic protein 414
BRD4bromodomain containing 420
CALCRcalcitonin receptor20
CALCAcalcitonin-related polypeptide alpha49
CAP1CAP, adenylate cyclase-associated protein 1 (yeast)1
CARTPTCART prepropeptide10
CARTCART prepropeptide51
CASP3caspase 3, apoptosis-related cysteine peptidase13
CASP7caspase 7, apoptosis-related cysteine peptidase1
CASP8caspase 8, apoptosis-related cysteine peptidase13
CCKBRcholecystokinin21
CCL5chemokine (C-C motif) ligand 520
CCL8chemokine (C-C motif) ligand 820
CCNB1cyclin B19
CCND1cyclin D114
CCND2cyclin D2142
CCND3cyclin D313
CDK5R2cyclin-dependent kinase 5, regulatory subunit 2 (p39)30
p21cip1cyclin-dependent kinase inhibitor 1A (p21, Cip1)2
CEBPGCCAAT/enhancer binding protein (C/EBP), gamma1
CHP2calcineurin-like EF-hand protein 29
TERTtescalcin9
CYP27B1cytochrome P450, family 27, subfamily B, polypeptide 120
CR1complement component (3b/4b) receptor 1 (Knops blood group)97
CREB1cAMP responsive element binding protein 19
CRHR1corticotropin releasing hormone receptor 19
CRKv-crk sarcoma virus CT10 oncogene homolog (avian)33
CSF1Rcolony stimulating factor 1 receptor13
CSF3colony stimulating factor 3 (granulocyte)13
CXCR4chemokine (C-X-C motif) receptor 48
DAB1Dab, reelin signal transducer, homolog 1 (Drosophila)37
DAPK1death-associated protein63
DAPdeath-associated protein197
DCTN1dynactin 120
DDX3XDEAD (Asp-Glu-Ala-Asp) box polypeptide 3, X-linked1
DEPDC1DEP domain containing 11
DNAJB11DnaJ (Hsp40) homolog, subfamily B, member 119
DNAJB6DnaJ (Hsp40) homolog, subfamily B, member 61
DOCK11dedicator of cytokinesis 11
DOCK2dedicator of cytokinesis 220
FLJ33718docking protein 71
DRD1dopamine receptor D150
DRD2dopamine receptor D231
DRD4dopamine receptor D421
DRD5dopamine receptor D520
EPB41L5erythrocyte membrane protein band 4.1 like 59
EDAectodysplasin A10
ELMOD1ELMO/CED-12 domain containing 11
ELA2elastase, neutrophil expressed1
EPHA2EPH receptor A21
EPHA4EPH receptor A41
EPHA5EPH receptor A563
EPHA8EPH receptor A820
EPOerythropoietin50
ERBB4v-erb-a erythroblastic leukemia viral oncogene homolog 4 (avian)49
ERCC2excision repair cross-complementing rodent repair deficiency, complementation group 29
ERepiregulin520
ESR1estrogen receptor 1109
EVI5Lecotropic viral integration site 5-like1
EXTL3exostosin-like glycosyltransferase 31
PFKFB26-phosphofructo-2-kinase/fructose-2,6-biphosphatase 21
FABP1fatty acid binding protein 1, liver20
FBLN1fibulin 121
FGF1fibroblast growth factor 10233
FGF12fibroblast growth factor 1351
FGF22fibroblast growth factor 2 (basic)9
FGFR1fibroblast growth factor receptor 114
FGFR2fibroblast growth factor receptor 214
FGFR3fibroblast growth factor receptor 31
FGFR4fibroblast growth factor receptor 413
FGRGardner-Rasheed feline sarcoma viral (v-fgr) oncogene homolog1
FLT3fms-related tyrosine kinase 342
FOXA1forkhead box A110
FOXJ1forkhead box J111
FOXL2forkhead box L249
FOXQ1forkhead box Q110
FTMTferritin mitochondrial1
FZD1frizzled family receptor 1041
FZD10frizzled family receptor 131
FZD2frizzled family receptor 210
FZD5frizzled family receptor 51
FZD8frizzled family receptor 89
FZR1fizzy/cell division cycle 20 related 1 (Drosophila)1
GADD45Bgrowth arrest and DNA-damage-inducible, beta9
GAS6growth arrest-specific 610
GATA3GATA binding protein 311
GNB2L1guanine nucleotide binding protein (G protein), beta polypeptide 2-like 11
ARHGDIBRho GDP dissociation inhibitor (GDI) beta13
ARHGDIGRho GDP dissociation inhibitor (GDI) gamma1
GDNFglial cell derived neurotrophic factor50
GHRHRgrowth hormone releasing hormone receptor20
GIPRgastric inhibitory polypeptide receptor9
GLP1Rglucagon-like peptide 1 receptor20
GMFGglia maturation factor, gamma1
GNAI2guanine nucleotide binding protein (G protein), alpha inhibiting activity polypeptide 29
GNAO1guanine nucleotide binding protein (G protein), alpha activating activity polypeptide O29
GNAT1guanine nucleotide binding protein (G protein), alpha transducing activity polypeptide 110
GPR55G protein-coupled receptor 5520
GREM1gremlin 1, DAN family BMP antagonist30
GRHL3grainyhead-like 3 (Drosophila)2
GRM1glutamate receptor, metabotropic 120
GRTP1growth hormone regulated TBC protein 19
GSTM2glutathione S-transferase mu 2 (muscle)13
HAND2heart and neural crest derivatives expressed 230
HDAC4histone deacetylase 41
HGFhepatocyte growth factor (hepapoietin A; scatter factor)20
HIP1huntingtin interacting protein 19
HMHA1histocompatibility (minor) HA-110
HSPA2heat shock 70kDa protein 29
HYOU1hypoxia up-regulated 19
IGFBP3insulin-like growth factor binding protein 3110
EIF2S1eukaryotic translation initiation factor 2, subunit 1 alpha, 35kDa1
IFNGinterferon, gamma13
IGF2BP3insulin-like growth factor 2 (somatomedin A)1
IL1Binterleukin 1, beta20
IL1RNinterleukin 1 receptor antagonist33
IL21Rinterleukin 220
IL8interleukin 833
INSRinsulin receptor11
INSM2insulin10
IRAK1interleukin-1 receptor-associated kinase 19
IRF4interferon regulatory factor 430
IRS1insulin receptor substrate 11
ISL1ISL LIM homeobox 11
ITKIL2-inducible T-cell kinase13
ITPR2inositol 1,4,5-trisphosphate receptor, type 214
JAK2Janus kinase 21
MAPK8IP2mitogen-activated protein kinase 8 interacting protein 21
MAPK8IP3mitogen-activated protein kinase 8 interacting protein 310
JMYjunction mediating and regulatory protein, p53 cofactor1
JPH2junctophilin 29
KDM1lysine (K)-specific demethylase 1A1
KITLGv-kit Hardy-Zuckerman 4 feline sarcoma viral oncogene homolog1
PRKCAprotein kinase C, alpha10
PRKCBprotein kinase C, beta31
PRKCB1protein kinase C, beta21
PRKD2protein kinase D21
PRKCHprotein kinase C, eta10
PRKCZprotein kinase C, zeta1
RPS6KA4ribosomal protein S6 kinase, 90kDa, polypeptide 41
Sykspleen tyrosine kinase3
SYKspleen tyrosine kinase13
LMF1lipase maturation factor 110
ALOX12Barachidonate 12-lipoxygenase9
EDG4lysophosphatidic acid receptor 29
LRP8low density lipoprotein receptor-related protein 8, apolipoprotein e receptor1
LHCGRluteinizing hormone/choriogonadotropin receptor20
MID1IP1MID1 interacting protein 11
MAP3K1mitogen-activated protein kinase kinase kinase 1022
MAP3K10mitogen-activated protein kinase kinase kinase 131
MAP3K13mitogen-activated protein kinase kinase kinase 1, E3 ubiquitin protein ligase20
MAP3K3mitogen-activated protein kinase kinase kinase 31
MAP3K7mitogen-activated protein kinase kinase kinase 738
MAP3K8mitogen-activated protein kinase kinase kinase 813
MAP4K1mitogen-activated protein kinase kinase kinase kinase 120
MALmal, T-cell differentiation protein40
MAPKAPK2mitogen-activated protein kinase-activated protein kinase 21
MDFIMyoD family inhibitor domain containing12
MDFICMyoD family inhibitor1
MED16mediator complex subunit 161
MEN1multiple endocrine neoplasia I24
AMHanti-Mullerian hormone30
MMP11matrix metallopeptidase 14 (membrane-inserted)20
MMP14matrix metallopeptidase 15 (membrane-inserted)1
MMP15matrix metallopeptidase 16 (membrane-inserted)1
MMP16matrix metallopeptidase 17 (membrane-inserted)29
MSH6mutS homolog 6 (E. coli)5
MT3metallothionein 345
MUC2 CpG54mucin 2, oligomeric mucus/gel-forming2
MYL4myosin, light chain 4, alkali; atrial, embryonic1
PPP1R12Bprotein phosphatase 1, regulatory subunit 12B1
CIAS1NLR family, pyrin domain containing 31
NEUROD1neuronal differentiation 149
NEUROD2neuronal differentiation 220
NEDD4Lneural precursor cell expressed, developmentally down-regulated 4-like, E3 ubiquitin protein ligase1
NFAM1NFAT activating protein with ITAM motif 120
NGFBnerve growth factor (beta polypeptide)33
NEUROG1neurogenin 191
NGN1neurogenin 124
NEUROG2neurogenin 210
NEUROG3neurogenin 330
NKX2-2NK2 homeobox 230
NKX2-5NK2 homeobox 530
NKX6-1NK6 homeobox 10
NLGN3neuroligin 31
CARD15nucleotide-binding oligomerization domain containing 213
NODALnodal growth differentiation factor10
NOS1nitric oxide synthase 1 (neuronal)21
NOS2Anitric oxide synthase 2, inducible33
NOS3nitric oxide synthase 3 (endothelial cell)34
NOX4NADPH oxidase 41
NPM2nucleophosmin/nucleoplasmin 21
NRG1neuregulin 123
NRP1neuropilin 11
NTF3neurotrophin 339
NTRK1neurotrophic tyrosine kinase, receptor, type 110
TrkAneurotrophic tyrosine kinase, receptor, type 12
NTRK2neurotrophic tyrosine kinase, receptor, type 231
NTRK3neurotrophic tyrosine kinase, receptor, type 362
P2RY11purinergic receptor P2Y, G-protein coupled, 111
TP73tumor protein p73100
p73tumor protein p7388
P73tumor protein p73156
ADCYAP1adenylate cyclase activating polypeptide 1 (pituitary)64
ADCYAP1R1adenylate cyclase activating polypeptide 1 (pituitary) receptor type I21
PAK3p21 protein (Cdc42/Rac)-activated kinase 31
F2Rcoagulation factor II (thrombin) receptor20
PDE5Aphosphodiesterase 5A, cGMP-specific1
PDPK13-phosphoinositide dependent protein kinase-120
PDX1pancreatic and duodenal homeobox 110
GPLD1glycosylphosphatidylinositol specific phospholipase D120
PITX2paired-like homeodomain 263
PLCG2phospholipase C, gamma 2 (phosphatidylinositol-specific)20
PLXNB2plexin B210
PPP1R3Gprotein phosphatase 1, regulatory subunit 3G10
PPARGC1Bperoxisome proliferator-activated receptor gamma1
CTSAcathepsin A9
PPM1Fprotein phosphatase, Mg2+/Mn2+ dependent, 1F1
DEPDC2phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 241
PPARGperoxisome proliferator-activated receptor gamma, coactivator 1 beta14
PROK1prokineticin 121
PROK2prokineticin 249
PSMC1proteasome (prosome, macropain) 26S subunit, ATPase, 11
PSMC3proteasome (prosome, macropain) 26S subunit, ATPase, 31
PSMA1proteasome (prosome, macropain) subunit, alpha type, 19
PSMA3proteasome (prosome, macropain) subunit, alpha type, 31
PSMA7proteasome (prosome, macropain) subunit, alpha type, 71
PSMD5proteasome (prosome, macropain) 26S subunit, non-ATPase, 520
PSMD8proteasome (prosome, macropain) 26S subunit, non-ATPase, 89
PTENphosphatase and tensin homolog9
RAD50RAD50 homolog (S. cerevisiae)1
RARAretinoic acid receptor, alpha96
RASA3RAS p21 protein activator 310
NRASneuroblastoma RAS viral (v-ras) oncogene homolog1
ERC1ELKS/RAB6-interacting/CAST family member 11
RALBP1ralA binding protein 11
RELNreelin78
RESTRE1-silencing transcription factor1
RGNregucalcin1
RASGRF1Ras protein-specific guanine nucleotide-releasing factor 163
RGS12regulator of G-protein signaling 129
RGS17regulator of G-protein signaling 1754
RGS20regulator of G-protein signaling 2026
ARHGAP4Rho GTPase activating protein 41
ARHGAP6Rho GTPase activating protein 61
DLC1deleted in liver cancer 113
ARHGAP9Rho GTPase activating protein 91
ARHGAP21Rho GTPase activating protein 219
ARHGAP22Rho GTPase activating protein 221
ARHGAP27Rho GTPase activating protein 271
RIN2Ras and Rab interactor 220
RIN3Ras and Rab interactor 332
RIPK3receptor-interacting serine-threonine kinase 333
UBA52ubiquitin A-52 residue ribosomal protein fusion product 11
ROBO1roundabout, axon guidance receptor, homolog 1 (Drosophila)10
MST1Rmacrophage stimulating 1 receptor (c-met-related tyrosine kinase)33
RAP1GAPRAP1 GTPase activating protein9
RPTORregulatory associated protein of MTOR, complex 11
RYR2ryanodine receptor 2 (cardiac)30
P8S100 calcium binding protein A8170
EDG1sphingosine-1-phosphate receptor 120
SLC27A1solute carrier family 27 (fatty acid transporter), member 11
KITKIT ligand15
SCRIBscribbled planar cell polarity protein1
SEMA4Dsema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D1
SERP1stress-associated endoplasmic reticulum protein 11
SFRP1secreted frizzled-related protein 1105
SARP2secreted frizzled-related protein 1235
SFRP2secreted frizzled-related protein 271
SGK1serum/glucocorticoid regulated kinase 11
SHANK3SH3 and multiple ankyrin repeat domains 31
SHC1SHC (Src homology 2 domain containing) transforming protein 11
SHHsonic hedgehog10
SKIv-ski sarcoma viral oncogene homolog (avian)41
SMOC2smoothened, frizzled family receptor50
SMARCB1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily b, member 19
SNX9sorting nexin 920
SOX7SRY (sex determining region Y)-box 710
SPAG8sperm associated antigen 89
SPDY1speedy/RINGO cell cycle regulator family member A1
SPHK1sphingosine kinase 19
SRCSRC kinase signaling inhibitor 134
STARD8StAR-related lipid transfer (START) domain containing 89
STIM2stromal interaction molecule 29
STK11serine/threonine kinase 119
LKB1serine/threonine kinase 1118
ALS2CR2STE20-related kinase adaptor beta9
SNCAIPsynuclein, alpha (non A4 component of amyloid precursor)41
MAP3K7IP1TGF-beta activated kinase 1/MAP3K7 binding protein 120
MAP3K7IP3TGF-beta activated kinase 1/MAP3K7 binding protein 39
TBC1D1TBC1 domain family, member 241
TAZTBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 11
TBC1D24tubulin folding cofactor D9
TBC1D2TBC1 domain family, member 210
TCF7L1transcription factor 7-like 2 (T-cell specific, HMG-box)1
TFRCtransforming growth factor, alpha10
TGFAtransforming growth factor, beta 11
TGFB1transforming growth factor, beta 21
TGFB2transforming growth factor, beta receptor II (70/80kDa)13
THPOThy-1 cell surface antigen20
MUC2 CpG47mucin 2, oligomeric mucus/gel-forming2
TLL2toll-like receptor 929
TNFSF10tumor necrosis factor (ligand) superfamily, member 1013
TNFSF11tumor necrosis factor (ligand) superfamily, member 1120
TNFRSF11Atumor necrosis factor receptor superfamily, member 11a, NFKB activator1
TOPORStopoisomerase I binding, arginine/serine-rich, E3 ubiquitin protein ligase1
TNFRSF10Atumor necrosis factor receptor superfamily, member 10a13
CART1TNF receptor-associated factor 440
TRAF7TNF receptor-associated factor 7, E3 ubiquitin protein ligase1
TRPC6transient receptor potential cation channel, subfamily C, member 651
THthrombospondin 1416
TWIST1twist basic helix-loop-helix transcription factor 1144
UBE2E1ubiquitin-conjugating enzyme E2E 11
UCNurocortin50
AVPR1Aarginine vasopressin receptor 1A10
AVPR2arginine vasopressin receptor 21
VAV2vav 2 guanine nucleotide exchange factor13
VAV3vav 3 guanine nucleotide exchange factor20
FLT1fms-related tyrosine kinase 143
VIPR2vasoactive intestinal peptide receptor 221
VLDLRvery low density lipoprotein receptor9
VTNvitronectin20
WRAP53WD repeat containing, antisense to TP531
WNT10Awingless-type MMTV integration site family, member 10B9
WNK2WNK lysine deficient protein kinase 220
WNT10Bwingless-type MMTV integration site family, member 111
WNT2Bwingless-type MMTV integration site family member 21
WNT3wingless-type MMTV integration site family, member 3A31
WNT3Awingless-type MMTV integration site family, member 321
WNT5Awingless-type MMTV integration site family, member 5A10
WNT7Awingless-type MMTV integration site family, member 7A39
WNT9Bwingless-type MMTV integration site family, member 9B20
XDHxanthine dehydrogenase40
RP2retinitis pigmentosa 2 (X-linked recessive)347
ZEB2zinc finger E-box binding homeobox 210
ZP4zona pellucida glycoprotein 421
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