Browse By Cell Line Result Page of OvirusTdb

The total number of records retrieved from this search are 93. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_730	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	10 MOI	100% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_732	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	50 MOI	50% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_734	Adenovirus	AdAFPp-E1A	DNA	Adenoviridae	The viral mutant with E1A gene driven by AFP promoter	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	Slight toxicity to HL-7702 cell line	MTT assay	100 MOI	38% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_736	Adenovirus	AdTrack	DNA	Adenoviridae	None	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	10 MOI	100% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_738	Adenovirus	AdTrack	DNA	Adenoviridae	None	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	50 MOI	100% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_740	Adenovirus	AdTrack	DNA	Adenoviridae	None	Yes	No	No	Institute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	100 MOI	100% cancer cell viability on day 5	No	No	NA	No response	NA	NA	NA	NA	27450327
OV_1192	Adenovirus	ONYX-015	DNA	Adenoviridae	None	Yes	No	No	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	95% cancer cell survival	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1193	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	Yes	No	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	90% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1194	Adenovirus	ONYX-015	DNA	Adenoviridae	None	No	ONYX-015 in combination with cisplatin (1microgram/ml)	No	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	50% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1195	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	No	ZD55-smac in combination with cisplatin (1microgram/ml)	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	60% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1196	Adenovirus	ONYX-015	DNA	Adenoviridae	None	No	ONYX-015 in combination with 5 FU (5 microgram/ml)	No	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	60% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1197	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	No	ZD55-smac in combination with 5 FU (5 microgram/ml)	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	65% cancer cell killing	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1198	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	Yes	No	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	No cell killing at after day 1	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1199	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	Yes	No	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	10% cell killing after day 2	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1200	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	Yes	No	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	25% cell killing after day 3	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1201	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	Yes	No	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	40% cell killing after day 4	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1202	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	No	ZD55-smac in combination with cisplatin (1microgram/ml)	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	10% cell killing after day 1	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1203	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	No	ZD55-smac in combination with cisplatin (1microgram/ml)	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	30% cell killing after day 2	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1204	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	No	ZD55-smac in combination with cisplatin (1microgram/ml)	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	50% cell killing after day 3	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1205	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	No	ZD55-smac in combination with cisplatin (1microgram/ml)	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	50% cell killing after day 4	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1206	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	Yes	No	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	No cell killing after day 1	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1207	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	Yes	No	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	10% cell killing after day 2	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1208	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	Yes	No	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	30% cell killing aftewr day 3	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1209	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	Yes	No	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	40% cell killing after day 4	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1210	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	No	ZD55-smac in combination with 5 FU (5 microgram/ml)	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	20% cell killing after day 1	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1211	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	No	ZD55-smac in combination with 5 FU (5 microgram/ml)	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	30% cell killing after day 2	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1212	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	No	ZD55-smac in combination with 5 FU (5 microgram/ml)	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	60% cell killing after day 3	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_1213	Adenovirus	ZD55-smac	DNA	Adenoviridae	Deletion of E1B-55K gene and addition of smac gene	No	ZD55-smac in combination with 5 FU (5 microgram/ml)	Virus expressing smac gene	Shanghai cell collection	Liver cancer cell line	Huh-7	NA	NA	MTT assay	1 MOI	60% cell killing after day 4	No	No	NA	No response	NA	NA	NA	NA	18031615
OV_2047	Vaccinia virus	GLV-1h68	DNA	Poxviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	0.1 MOI	50% cell survival after 24 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer cell line	Increased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	NA	21779374
OV_2048	Vaccinia virus	GLV-1h68	DNA	Poxviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	0.1 MOI	20% cell survival after 48 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer cell line	Increased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	NA	21779374
OV_2049	Vaccinia virus	GLV-1h68	DNA	Poxviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	0.1 MOI	20% cell survival after 72 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer cell line	Increased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	NA	21779374
OV_2050	Vaccinia virus	GLV-1h68	DNA	Poxviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	0.1 MOI	22% cell survival after 96 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer cell line	Increased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	NA	21779374
OV_2051	Vaccinia virus	GLV-1h68	DNA	Poxviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	1 MOI	90% cell survival after 24 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer cell line	Increased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	NA	21779374
OV_2052	Vaccinia virus	GLV-1h68	DNA	Poxviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	1 MOI	58% cell survival after 48 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer cell line	Increased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	NA	21779374
OV_2053	Vaccinia virus	GLV-1h68	DNA	Poxviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	1 MOI	30% cell survial after 72 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer cell line	Increased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	NA	21779374
OV_2054	Vaccinia virus	GLV-1h68	DNA	Poxviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	1 MOI	22% cell survival after 96 hours	No	No	NA	No response	NA	Induction of apoptosis in cancer cell line	Increased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	NA	21779374
OV_2064	Vaccinia virus	GLV-1h68	DNA	Poxviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	NA	NA	NA	Athymic hsd nude mice xenograft for PLC cell line	5.0E+6 pfu	Reduction in tumor volume below 3000mm compared to control after 35 days		NA	Induction of apoptosis in cancer cell line	Increased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	NA	21779374
OV_2110	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of AFP gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	Crystal violet staining	0.1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2111	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of AFP gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	Crystal violet staining	1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2112	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of AFP gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	Crystal violet staining	10 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2113	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of AFP gene	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	Crystal violet staining	100 MOI	Most of the cells are died	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2130	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of TRAIL gene	Yes	No	Virus expressing TRAIL gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	Crystal violet staining	0.1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2131	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of TRAIL gene	Yes	No	Virus expressing TRAIL gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	Crystal violet staining	1 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2132	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of TRAIL gene	Yes	No	Virus expressing TRAIL gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	Crystal violet staining	10 MOI	Some cell death observed	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2133	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of TRAIL gene	Yes	No	Virus expressing TRAIL gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	Crystal violet staining	100 MOI	Most of the cells are died	No	No	NA	No response	NA	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2138	Adenovirus	Mutant	DNA	Adenoviridae	Deletion of E1BK55KD gene and addition of TRAIL gene	Yes	No	Virus expressing TRAIL gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	NA	NA	NA	BALB/c mice xenograft for Huh7 cell line (5.0E+6 Ã— 10â¶ pfu)	2.0E+9 pfu	NA	Significant reduction in tumor volume below 100mm and increase in median survival time after 57 days	Intratumoral	Induction of apoptosis in cancer as measured by TUNEL assay	NA	NA	21979578
OV_2528	Adenovirus	AD55-Apoptin	DNA	Adenoviridae	Deletion of E1B gene and insertion of Apoptin gene	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	0.1 MOI	90% cells are viable	No	No	NA	No response	NA	Induction of apotosis as measured by TUNEL assay	NA	NA	22321574
OV_2529	Adenovirus	AD55-Apoptin	DNA	Adenoviridae	Deletion of E1B gene and insertion of Apoptin gene	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	1 MOI	100% cells are viable	No	No	NA	No response	NA	Induction of apotosis as measured by TUNEL assay	NA	NA	22321574
OV_2530	Adenovirus	AD55-Apoptin	DNA	Adenoviridae	Deletion of E1B gene and insertion of Apoptin gene	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	10 MOI	35% cells are viable	No	No	NA	No response	NA	Induction of apotosis as measured by TUNEL assay	NA	NA	22321574
OV_2549	Adenovirus	AD55-Apoptin	DNA	Adenoviridae	Deletion of E1B gene and insertion of Apoptin gene	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	10 MOI	90% cells viable after day 1	No	No	NA	No response	NA	Induction of apotosis as measured by TUNEL assay	NA	NA	22321574
OV_2550	Adenovirus	AD55-Apoptin	DNA	Adenoviridae	Deletion of E1B gene and insertion of Apoptin gene	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	10 MOI	70% cells viable after day 2	No	No	NA	No response	NA	Induction of apotosis as measured by TUNEL assay	NA	NA	22321574
OV_2551	Adenovirus	AD55-Apoptin	DNA	Adenoviridae	Deletion of E1B gene and insertion of Apoptin gene	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	10 MOI	50% cells viable after day 3	No	No	NA	No response	NA	Induction of apotosis as measured by TUNEL assay	NA	NA	22321574
OV_2552	Adenovirus	AD55-Apoptin	DNA	Adenoviridae	Deletion of E1B gene and insertion of Apoptin gene	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	MTT assay	10 MOI	30% cells viable after day 4	No	No	NA	No response	NA	Induction of apotosis as measured by TUNEL assay	NA	NA	22321574
OV_2553	Adenovirus	AD55-Apoptin	DNA	Adenoviridae	Deletion of E1B gene and insertion of Apoptin gene	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for Huh7 cell line (1.0E+7)	3.0E+8 pfu	NA	Reduction in tumor volume below 425mm after 16 days	Intratumoral	Induction of apotosis as measured by TUNEL assay	NA	NA	22321574
OV_2589	Adenovirus	Ad.enAFP-E1A-delta-E1B-IL-24	DNA	Adenoviridae	Deletion of E1A, E1B and addition of AFP and IL-24	Yes	No	Virus expressing IL-24 gene	ATCC	Human liver cancer cell line	Huh-7	5.0E+4 cells per well	NA	MTT assay	10 MOI	10% cells are viable after 4 days	No	No	NA	No response	NA	Induction of apoptosis in cancer	Upregulation of GADD34	NA	22790965
OV_2601	Adenovirus	Ad.enAFP-E1A-delta-E1B-IL-24	DNA	Adenoviridae	Deletion of E1A, E1B and addition of AFP and IL-24	Yes	No	Virus expressing IL-24 gene	ATCC	Human liver cancer cell line	Huh-7	5.0E+4 cells per well	NA	Crystal violet staining	0.1 MOI	100% cells viavility	No	No	NA	No response	NA	Induction of apoptosis in cancer	Upregulation of GADD34	NA	22790965
OV_2602	Adenovirus	Ad.enAFP-E1A-delta-E1B-IL-24	DNA	Adenoviridae	Deletion of E1A, E1B and addition of AFP and IL-24	Yes	No	Virus expressing IL-24 gene	ATCC	Human liver cancer cell line	Huh-7	5.0E+4 cells per well	NA	Crystal violet staining	1 MOI	Some cells are viable	No	No	NA	No response	NA	Induction of apoptosis in cancer	Upregulation of GADD34	NA	22790965
OV_2603	Adenovirus	Ad.enAFP-E1A-delta-E1B-IL-24	DNA	Adenoviridae	Deletion of E1A, E1B and addition of AFP and IL-24	Yes	No	Virus expressing IL-24 gene	ATCC	Human liver cancer cell line	Huh-7	5.0E+4 cells per well	NA	Crystal violet staining	10 MOI	100% cell death	No	No	NA	No response	NA	Induction of apoptosis in cancer	Upregulation of GADD34	NA	22790965
OV_2604	Adenovirus	Ad.enAFP-E1A-delta-E1B-IL-24	DNA	Adenoviridae	Deletion of E1A, E1B and addition of AFP and IL-24	Yes	No	Virus expressing IL-24 gene	ATCC	Human liver cancer cell line	Huh-7	5.0E+4 cells per well	NA	Crystal violet staining	100 MOI	100% cell death	No	No	NA	No response	NA	Induction of apoptosis in cancer	Upregulation of GADD34	NA	22790965
OV_2605	Adenovirus	Ad.enAFP-E1A-delta-E1B-IL-24	DNA	Adenoviridae	Deletion of E1A, E1B and addition of AFP and IL-24	Yes	No	Virus expressing IL-24 gene	ATCC	Human liver cancer cell line	Huh-7	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for Huh7 cell line (5.0E+6 cells)	4.0E+8 pfu	NA	Complete regression in tumor after 28 days	Intratumoral	Induction of apoptosis in cancer	Upregulation of GADD34	NA	22790965
OV_2698	Adenovirus	AdCN205-IL12	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-12 gene	Shanghai cell collection	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	Spectrophotometer	10 MOI	85% cell viability after 24 hours	No	No	NA	No response	NA	NA	NA	NA	23028626
OV_2699	Adenovirus	AdCN205-IL12	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-12 gene	Shanghai cell collection	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	Spectrophotometer	10 MOI	80% cell viability after 48 hours	No	No	NA	No response	NA	NA	NA	NA	23028626
OV_2700	Adenovirus	AdCN205-IL12	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-12 gene	Shanghai cell collection	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	Spectrophotometer	10 MOI	70% cell viability after 72 hours	No	No	NA	No response	NA	NA	NA	NA	23028626
OV_2701	Adenovirus	AdCN205-IL12	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-12 gene	Shanghai cell collection	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	Spectrophotometer	10 MOI	40% cell viability after 96 hours	No	No	NA	No response	NA	NA	NA	NA	23028626
OV_2702	Adenovirus	AdCN205-IL12	DNA	Adenoviridae	None	No	Virus in combination with CIK	Virus expressing IL-12 gene	Shanghai cell collection	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	Spectrophotometer	10 MOI	70% cell viability after 24 hours	No	No	NA	No response	NA	NA	NA	NA	23028626
OV_2703	Adenovirus	AdCN205-IL12	DNA	Adenoviridae	None	No	Virus in combination with CIK	Virus expressing IL-12 gene	Shanghai cell collection	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	Spectrophotometer	10 MOI	40% cell viability after 48 hours	No	No	NA	No response	NA	NA	NA	NA	23028626
OV_2704	Adenovirus	AdCN205-IL12	DNA	Adenoviridae	None	No	Virus in combination with CIK	Virus expressing IL-12 gene	Shanghai cell collection	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	Spectrophotometer	10 MOI	20% cell viability after 72 hours	No	No	NA	No response	NA	NA	NA	NA	23028626
OV_2708	Adenovirus	AdCN205-IL12	DNA	Adenoviridae	None	No	Virus strain in combination with CIK (1 Ã— 10â· )	Virus expressing IL-12 gene	Shanghai cell collection	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	NA	NA	NA	SCID mice xenograft for Huh7 (1.0E+6 cell)	2.0E+8 pfu	NA	Reduction in tumor volume below 100mm after 40 days and increase in median survival time 40 days	Intratumoral	NA	NA	NA	23028626
OV_2709	Adenovirus	AdCN205-IL12	DNA	Adenoviridae	None	No	Virus strain in combination with CIK (1 Ã— 10â· )	Virus expressing IL-12 gene	Shanghai cell collection	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	NA	NA	NA	SCID mice xenograft for Huh7 (1.0E+6 cell)	2.0E+8 pfu	NA	Reduction in tumor volume below 100mm after 40 days and increase in median survival time 40 days	Intravenous	NA	NA	NA	23028626
OV_2747	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	90% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2748	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	80% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2749	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	60% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2750	Adenovirus	AdCN205	DNA	Adenoviridae	None	Yes	No	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	40% cell viability after 96 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2751	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	90% cell viability after 24 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2752	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	50% cell viability after 48 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2753	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	30% cell viability after 72 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2754	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	1.0E+4 cells per well	NA	MTT assay	5 MOI	20% cell viability after 96 hours	No	No	NA	No response	NA	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_2755	Adenovirus	AdCN205	DNA	Adenoviridae	None	No	Virus strain in combination with miR-34-a	Virus expressing IL-24 gene	ATCC	Human hepatocellular carcinoma cell line	Huh-7	NA	NA	NA	NA	NA	BALB/c nude mice xenograft for Huh cell (2.0E+6 cell)	7.0E+8 pfu	NA	Complete regression in tumor volume after 49 days	Intratumoral	Induction of apoptosis, G1 arrest and sensescence	Inhibition of oncogene and antiapototic gene	NA	23292172
OV_4299	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma	Huh-7	4000 cells per well	NA	MTT assay	10 pfu	52.2 % cell viability after 72 hours	No	No	NA	No response	NA	Activation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	NA	NA	26373347
OV_4881	Adenovirus	Ad-deltaB	DNA	Adenoviridae	None	Yes	No	No	JCRB gene bank japan	Human hepatocellular carcinoma	Huh-7	70% confluence on 24 well plate	NA	MTT assay	5 MOI	80% cell viability after 48 hours	No	No	NA	No response	NA	Combination therapy and alone promotes apoptosis	Activation of caspase-3 and 8 and upregulation of IFN-gamma	NA	27154307
OV_4882	Adenovirus	Ad-deltaB	DNA	Adenoviridae	None	Yes	No	No	JCRB gene bank japan	Human hepatocellular carcinoma	Huh-7	70% confluence on 24 well plate	NA	MTT assay	10 MOI	60% cell viability after 48 hours	No	No	NA	No response	NA	Combination therapy and alone promotes apoptosis	Activation of caspase-3 and 8 and upregulation of IFN-gamma	NA	27154307
OV_4883	Adenovirus	Ad-deltaB	DNA	Adenoviridae	Expressing TRAIL and IL-12 gene in under CMV promoter in deleted E3 region of virus backbone	Yes	No	Virus expressing IL12 gene	JCRB gene bank japan	Human hepatocellular carcinoma	Huh-7	70% confluence on 24 well plate	NA	MTT assay	10 MOI	20% cell viability after 48 hours	No	No	NA	No response	NA	Combination therapy and alone promotes apoptosis	Activation of caspase-3 and 8 and upregulation of IFN-gamma	NA	27154307
OV_4884	Adenovirus	Ad-deltaB	DNA	Adenoviridae	Expressing TRAIL and IL-12 gene in under CMV promoter in deleted E3 region of virus backbone	Yes	No	Virus expressing IL12 gene	JCRB gene bank japan	Human hepatocellular carcinoma	Huh-7	70% confluence on 24 well plate	NA	MTT assay	20 MOI	10% cell viability after 48 hours	No	No	NA	No response	NA	Combination therapy and alone promotes apoptosis	Activation of caspase-3 and 8 and upregulation of IFN-gamma	NA	27154307
OV_5214	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5215	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5216	Adenovirus	wild type	DNA	Adenoviridae	None	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5217	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5218	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5219	Adenovirus	TRAD-shLuc	DNA	Adenoviridae	Virus having shorthairpin RNA for Luciferase gene knockout	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5220	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	100% cell viable after 24 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5221	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	80% cell viable after 48 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5222	Adenovirus	TRAD-shDICER	DNA	Adenoviridae	Virus having shorthairpin RNA for DICER	Yes	No	No	JCRB cell bank	Human hepatocellular carcinoma cell line	Huh-7	NA	Toxic to normal human cell line above 10 MOI	Alamar blue assay	2 MOI	20% cell viable after 72 hours	No	No	NA	No response	NA	NA	NA	NA	27760834
OV_5340	Newcastle disease virus	LaSota	RNA	Paramyxoviridae	None	Yes	No	No	ATCC	Human hepatocellular carcinoma cell line	Huh-7	5.0E+4 cells per well	NA	MTT assay	0.001 MOI	37% cells remain viable after 72 hours	No	No	NA	No response	NA	Virus induce apoptosis	Induced production of IFN-alpha, IFN-beta, IL-6and IFN-gamma	NA	28293547