| Primary information |
|---|
| OV_ID | OV_4883 |
| Virus Name | Adenovirus |
| Strain | Ad-deltaB |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Expressing TRAIL and IL-12 gene in under CMV promoter in deleted E3 region of virus backbone |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | Virus expressing IL12 gene |
| Source of cell line | JCRB gene bank japan |
| Origin of cell line | Human hepatocellular carcinoma |
| Cell line | Huh-7 |
| Concentration of cell line | 70 |
| In-vitro toxicity | NA |
| Assay | MTT assay |
| In-vitro virus concentration | 10 MOI |
| In-vitro result | 20% cell viability after 48 hours |
| Model organism | No |
| In-vivo virus concentration | No |
| In-vivo toxicity | NA |
| In-vivo result | No response |
| Mode of delivery | NA |
| Pathway induction | Combination therapy and alone promotes apoptosis |
| Immunogenic effect | Activation of caspase-3 and 8 and upregulation of IFN-gamma |
| Clinical trial | NA |
| PMID | 27154307 |