Detailed description page of Selected OV_ID


OV_2047 details
Primary information
OV_IDOV_2047
Virus Name Vaccinia virus
StrainGLV-1h68
Virus typeDNA
Virus familyPoxviridae
Modification in virus genomeNone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman hepatocellular carcinoma cell line
Cell lineHuh-7
Concentration of cell line0
In-vitro toxicityNA
AssayMTT assay
In-vitro virus concentration0.1 MOI
In-vitro result50% cell survival after 24 hours
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionInduction of apoptosis in cancer cell line
Immunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2
Clinical trialNA
PMID21779374