Detailed description page of Selected OV_ID


OV_2708 details
Primary information
OV_IDOV_2708
Virus Name Adenovirus
StrainAdCN205-IL12
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeNone
Virus aloneNo
Virus in combination iwth drug/radiationVirus strain in combination with CIK (1 × 10⁷ )
Immune gene induction in virus genomeVirus expressing IL-12 gene
Source of cell lineShanghai cell collection
Origin of cell lineHuman hepatocellular carcinoma cell line
Cell lineHuh-7
Concentration of cell line0
In-vitro toxicityNA
AssayNA
In-vitro virus concentrationNA
In-vitro resultNA
Model organismSCID mice xenograft for Huh7 (1 × 10⁶ cell)
In-vivo virus concentration2 × 10⁸ pfu
In-vivo toxicityNA
In-vivo resultReduction in tumor volume below 100mm after 40 days and increase in median survival time 40 days
Mode of deliveryIntratumoral
Pathway inductionNA
Immunogenic effectNA
Clinical trialNA
PMID23028626