| Primary information |
|---|
| OV_ID | OV_2708 |
| Virus Name | Adenovirus |
| Strain | AdCN205-IL12 |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | None |
| Virus alone | No |
| Virus in combination iwth drug/radiation | Virus strain in combination with CIK (1 × 10ⷠ) |
| Immune gene induction in virus genome | Virus expressing IL-12 gene |
| Source of cell line | Shanghai cell collection |
| Origin of cell line | Human hepatocellular carcinoma cell line |
| Cell line | Huh-7 |
| Concentration of cell line | 0 |
| In-vitro toxicity | NA |
| Assay | NA |
| In-vitro virus concentration | NA |
| In-vitro result | NA |
| Model organism | SCID mice xenograft for Huh7 (1 × 10ⶠcell) |
| In-vivo virus concentration | 2 × 10⸠pfu
|
| In-vivo toxicity | NA |
| In-vivo result | Reduction in tumor volume below 100mm after 40 days and increase in median survival time 40 days |
| Mode of delivery | Intratumoral |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 23028626 |