Detailed description page of Selected OV_ID


OV_4884 details
Primary information
OV_IDOV_4884
Virus Name Adenovirus
StrainAd-deltaB
Virus typeDNA
Virus familyAdenoviridae
Modification in virus genomeExpressing TRAIL and IL-12 gene in under CMV promoter in deleted E3 region of virus backbone
Virus aloneYes
Virus in combination iwth drug/radiationNo
Immune gene induction in virus genomeVirus expressing IL12 gene
Source of cell lineJCRB gene bank japan
Origin of cell lineHuman hepatocellular carcinoma
Cell lineHuh-7
Concentration of cell line70
In-vitro toxicityNA
AssayMTT assay
In-vitro virus concentration20 MOI
In-vitro result10% cell viability after 48 hours
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionCombination therapy and alone promotes apoptosis
Immunogenic effectActivation of caspase-3 and 8 and upregulation of IFN-gamma
Clinical trialNA
PMID27154307