The total number of records retrieved from this search are 93. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
IDOV_730	Virus nameAdenovirus	Virus strainAdAFPp-E1A	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationThe viral mutant with E1A gene driven by AFP promoter	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineInstitute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicitySlight toxicity to HL-7702 cell line	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result100% cancer cell viability on day 5	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27450327
IDOV_732	Virus nameAdenovirus	Virus strainAdAFPp-E1A	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationThe viral mutant with E1A gene driven by AFP promoter	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineInstitute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicitySlight toxicity to HL-7702 cell line	AssayMTT assay	In-vitro virus concentration50 MOI	In-vitro result50% cancer cell viability on day 5	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27450327
IDOV_734	Virus nameAdenovirus	Virus strainAdAFPp-E1A	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationThe viral mutant with E1A gene driven by AFP promoter	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineInstitute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicitySlight toxicity to HL-7702 cell line	AssayMTT assay	In-vitro virus concentration100 MOI	In-vitro result38% cancer cell viability on day 5	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27450327
IDOV_736	Virus nameAdenovirus	Virus strainAdTrack	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineInstitute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result100% cancer cell viability on day 5	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27450327
IDOV_738	Virus nameAdenovirus	Virus strainAdTrack	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineInstitute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration50 MOI	In-vitro result100% cancer cell viability on day 5	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27450327
IDOV_740	Virus nameAdenovirus	Virus strainAdTrack	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineInstitute of Hematology and Blood Diseases Hospital, Chinese Academy of Medical Sciences, and Peking Union Medical College (PUMC), Tianjin, China	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration100 MOI	In-vitro result100% cancer cell viability on day 5	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27450327
IDOV_1192	Virus nameAdenovirus	Virus strainONYX-015	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result95% cancer cell survival	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1193	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result90% cancer cell killing	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1194	Virus nameAdenovirus	Virus strainONYX-015	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneNo	Virus in combination with drug/radiationONYX-015 in combination with cisplatin (1microgram/ml)	Immune gene insertion in viral genomeNo	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result50% cancer cell killing	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1195	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneNo	Virus in combination with drug/radiationZD55-smac in combination with cisplatin (1microgram/ml)	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result60% cancer cell killing	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1196	Virus nameAdenovirus	Virus strainONYX-015	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneNo	Virus in combination with drug/radiationONYX-015 in combination with 5 FU (5 microgram/ml)	Immune gene insertion in viral genomeNo	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result60% cancer cell killing	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1197	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneNo	Virus in combination with drug/radiationZD55-smac in combination with 5 FU (5 microgram/ml)	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result65% cancer cell killing	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1198	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro resultNo cell killing at after day 1	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1199	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result10% cell killing after day 2	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1200	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result25% cell killing after day 3	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1201	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result40% cell killing after day 4	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1202	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneNo	Virus in combination with drug/radiationZD55-smac in combination with cisplatin (1microgram/ml)	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result10% cell killing after day 1	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1203	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneNo	Virus in combination with drug/radiationZD55-smac in combination with cisplatin (1microgram/ml)	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result30% cell killing after day 2	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1204	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneNo	Virus in combination with drug/radiationZD55-smac in combination with cisplatin (1microgram/ml)	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result50% cell killing after day 3	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1205	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneNo	Virus in combination with drug/radiationZD55-smac in combination with cisplatin (1microgram/ml)	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result50% cell killing after day 4	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1206	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro resultNo cell killing after day 1	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1207	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result10% cell killing after day 2	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1208	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result30% cell killing aftewr day 3	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1209	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result40% cell killing after day 4	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1210	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneNo	Virus in combination with drug/radiationZD55-smac in combination with 5 FU (5 microgram/ml)	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result20% cell killing after day 1	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1211	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneNo	Virus in combination with drug/radiationZD55-smac in combination with 5 FU (5 microgram/ml)	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result30% cell killing after day 2	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1212	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneNo	Virus in combination with drug/radiationZD55-smac in combination with 5 FU (5 microgram/ml)	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result60% cell killing after day 3	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_1213	Virus nameAdenovirus	Virus strainZD55-smac	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B-55K gene and addition of smac gene	Virus aloneNo	Virus in combination with drug/radiationZD55-smac in combination with 5 FU (5 microgram/ml)	Immune gene insertion in viral genomeVirus expressing smac gene	Source of cell lineShanghai cell collection	Origin of cell lineLiver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result60% cell killing after day 4	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID18031615
IDOV_2047	Virus nameVaccinia virus	Virus strainGLV-1h68	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration0.1 MOI	In-vitro result50% cell survival after 24 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer cell line	Immunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	Clinical trialNA	PMID21779374
IDOV_2048	Virus nameVaccinia virus	Virus strainGLV-1h68	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration0.1 MOI	In-vitro result20% cell survival after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer cell line	Immunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	Clinical trialNA	PMID21779374
IDOV_2049	Virus nameVaccinia virus	Virus strainGLV-1h68	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration0.1 MOI	In-vitro result20% cell survival after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer cell line	Immunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	Clinical trialNA	PMID21779374
IDOV_2050	Virus nameVaccinia virus	Virus strainGLV-1h68	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration0.1 MOI	In-vitro result22% cell survival after 96 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer cell line	Immunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	Clinical trialNA	PMID21779374
IDOV_2051	Virus nameVaccinia virus	Virus strainGLV-1h68	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result90% cell survival after 24 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer cell line	Immunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	Clinical trialNA	PMID21779374
IDOV_2052	Virus nameVaccinia virus	Virus strainGLV-1h68	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result58% cell survival after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer cell line	Immunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	Clinical trialNA	PMID21779374
IDOV_2053	Virus nameVaccinia virus	Virus strainGLV-1h68	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result30% cell survial after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer cell line	Immunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	Clinical trialNA	PMID21779374
IDOV_2054	Virus nameVaccinia virus	Virus strainGLV-1h68	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result22% cell survival after 96 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer cell line	Immunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	Clinical trialNA	PMID21779374
IDOV_2064	Virus nameVaccinia virus	Virus strainGLV-1h68	Virus genome typeDNA	Virus familyPoxviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayNA	In-vitro virus concentrationNA	In-vitro resultNA	Model organismAthymic hsd nude mice xenograft for PLC cell line	In-vivo virus concentration5.0E+6 pfu	In-vivo toxicityReduction in tumor volume below 3000mm compared to control after 35 days	In-vivo result	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer cell line	Immunogenic effectIncreased expression of immunological gene such as GM-CSF, IFN-gamma, IL-6,2,12,18, IP-10, MCP-1,3,5, TNF-alpha and MIP-2	Clinical trialNA	PMID21779374
IDOV_2110	Virus nameAdenovirus	Virus strainMutant	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1BK55KD gene and addition of AFP gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayCrystal violet staining	In-vitro virus concentration0.1 MOI	In-vitro resultSome cell death observed	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID21979578
IDOV_2111	Virus nameAdenovirus	Virus strainMutant	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1BK55KD gene and addition of AFP gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayCrystal violet staining	In-vitro virus concentration1 MOI	In-vitro resultSome cell death observed	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID21979578
IDOV_2112	Virus nameAdenovirus	Virus strainMutant	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1BK55KD gene and addition of AFP gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayCrystal violet staining	In-vitro virus concentration10 MOI	In-vitro resultSome cell death observed	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID21979578
IDOV_2113	Virus nameAdenovirus	Virus strainMutant	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1BK55KD gene and addition of AFP gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayCrystal violet staining	In-vitro virus concentration100 MOI	In-vitro resultMost of the cells are died	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID21979578
IDOV_2130	Virus nameAdenovirus	Virus strainMutant	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1BK55KD gene and addition of TRAIL gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing TRAIL gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayCrystal violet staining	In-vitro virus concentration0.1 MOI	In-vitro resultSome cell death observed	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID21979578
IDOV_2131	Virus nameAdenovirus	Virus strainMutant	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1BK55KD gene and addition of TRAIL gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing TRAIL gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayCrystal violet staining	In-vitro virus concentration1 MOI	In-vitro resultSome cell death observed	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID21979578
IDOV_2132	Virus nameAdenovirus	Virus strainMutant	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1BK55KD gene and addition of TRAIL gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing TRAIL gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayCrystal violet staining	In-vitro virus concentration10 MOI	In-vitro resultSome cell death observed	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID21979578
IDOV_2133	Virus nameAdenovirus	Virus strainMutant	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1BK55KD gene and addition of TRAIL gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing TRAIL gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayCrystal violet staining	In-vitro virus concentration100 MOI	In-vitro resultMost of the cells are died	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID21979578
IDOV_2138	Virus nameAdenovirus	Virus strainMutant	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1BK55KD gene and addition of TRAIL gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing TRAIL gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayNA	In-vitro virus concentrationNA	In-vitro resultNA	Model organismBALB/c mice xenograft for Huh7 cell line (5.0E+6 × 10⁶ pfu)	In-vivo virus concentration2.0E+9 pfu	In-vivo toxicityNA	In-vivo resultSignificant reduction in tumor volume below 100mm and increase in median survival time after 57 days	Mode of deliveryIntratumoral	Pathway inducedInduction of apoptosis in cancer as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID21979578
IDOV_2528	Virus nameAdenovirus	Virus strainAD55-Apoptin	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of Apoptin gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration0.1 MOI	In-vitro result90% cells are viable	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apotosis as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID22321574
IDOV_2529	Virus nameAdenovirus	Virus strainAD55-Apoptin	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of Apoptin gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration1 MOI	In-vitro result100% cells are viable	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apotosis as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID22321574
IDOV_2530	Virus nameAdenovirus	Virus strainAD55-Apoptin	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of Apoptin gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result35% cells are viable	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apotosis as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID22321574
IDOV_2549	Virus nameAdenovirus	Virus strainAD55-Apoptin	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of Apoptin gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result90% cells viable after day 1	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apotosis as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID22321574
IDOV_2550	Virus nameAdenovirus	Virus strainAD55-Apoptin	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of Apoptin gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result70% cells viable after day 2	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apotosis as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID22321574
IDOV_2551	Virus nameAdenovirus	Virus strainAD55-Apoptin	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of Apoptin gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result50% cells viable after day 3	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apotosis as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID22321574
IDOV_2552	Virus nameAdenovirus	Virus strainAD55-Apoptin	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of Apoptin gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result30% cells viable after day 4	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apotosis as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID22321574
IDOV_2553	Virus nameAdenovirus	Virus strainAD55-Apoptin	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1B gene and insertion of Apoptin gene	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayNA	In-vitro virus concentrationNA	In-vitro resultNA	Model organismBALB/c nude mice xenograft for Huh7 cell line (1.0E+7)	In-vivo virus concentration3.0E+8 pfu	In-vivo toxicityNA	In-vivo resultReduction in tumor volume below 425mm after 16 days	Mode of deliveryIntratumoral	Pathway inducedInduction of apotosis as measured by TUNEL assay	Immunogenic effectNA	Clinical trialNA	PMID22321574
IDOV_2589	Virus nameAdenovirus	Virus strainAd.enAFP-E1A-delta-E1B-IL-24	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1A, E1B and addition of AFP and IL-24	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman liver cancer cell line	Cell lineHuh-7	Concentration of cell line5.0E+4 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result10% cells are viable after 4 days	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer	Immunogenic effectUpregulation of GADD34	Clinical trialNA	PMID22790965
IDOV_2601	Virus nameAdenovirus	Virus strainAd.enAFP-E1A-delta-E1B-IL-24	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1A, E1B and addition of AFP and IL-24	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman liver cancer cell line	Cell lineHuh-7	Concentration of cell line5.0E+4 cells per well	In-vitro toxicityNA	AssayCrystal violet staining	In-vitro virus concentration0.1 MOI	In-vitro result100% cells viavility	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer	Immunogenic effectUpregulation of GADD34	Clinical trialNA	PMID22790965
IDOV_2602	Virus nameAdenovirus	Virus strainAd.enAFP-E1A-delta-E1B-IL-24	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1A, E1B and addition of AFP and IL-24	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman liver cancer cell line	Cell lineHuh-7	Concentration of cell line5.0E+4 cells per well	In-vitro toxicityNA	AssayCrystal violet staining	In-vitro virus concentration1 MOI	In-vitro resultSome cells are viable	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer	Immunogenic effectUpregulation of GADD34	Clinical trialNA	PMID22790965
IDOV_2603	Virus nameAdenovirus	Virus strainAd.enAFP-E1A-delta-E1B-IL-24	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1A, E1B and addition of AFP and IL-24	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman liver cancer cell line	Cell lineHuh-7	Concentration of cell line5.0E+4 cells per well	In-vitro toxicityNA	AssayCrystal violet staining	In-vitro virus concentration10 MOI	In-vitro result100% cell death	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer	Immunogenic effectUpregulation of GADD34	Clinical trialNA	PMID22790965
IDOV_2604	Virus nameAdenovirus	Virus strainAd.enAFP-E1A-delta-E1B-IL-24	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1A, E1B and addition of AFP and IL-24	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman liver cancer cell line	Cell lineHuh-7	Concentration of cell line5.0E+4 cells per well	In-vitro toxicityNA	AssayCrystal violet staining	In-vitro virus concentration100 MOI	In-vitro result100% cell death	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis in cancer	Immunogenic effectUpregulation of GADD34	Clinical trialNA	PMID22790965
IDOV_2605	Virus nameAdenovirus	Virus strainAd.enAFP-E1A-delta-E1B-IL-24	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationDeletion of E1A, E1B and addition of AFP and IL-24	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman liver cancer cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayNA	In-vitro virus concentrationNA	In-vitro resultNA	Model organismBALB/c nude mice xenograft for Huh7 cell line (5.0E+6 cells)	In-vivo virus concentration4.0E+8 pfu	In-vivo toxicityNA	In-vivo resultComplete regression in tumor after 28 days	Mode of deliveryIntratumoral	Pathway inducedInduction of apoptosis in cancer	Immunogenic effectUpregulation of GADD34	Clinical trialNA	PMID22790965
IDOV_2698	Virus nameAdenovirus	Virus strainAdCN205-IL12	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-12 gene	Source of cell lineShanghai cell collection	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssaySpectrophotometer	In-vitro virus concentration10 MOI	In-vitro result85% cell viability after 24 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID23028626
IDOV_2699	Virus nameAdenovirus	Virus strainAdCN205-IL12	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-12 gene	Source of cell lineShanghai cell collection	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssaySpectrophotometer	In-vitro virus concentration10 MOI	In-vitro result80% cell viability after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID23028626
IDOV_2700	Virus nameAdenovirus	Virus strainAdCN205-IL12	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-12 gene	Source of cell lineShanghai cell collection	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssaySpectrophotometer	In-vitro virus concentration10 MOI	In-vitro result70% cell viability after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID23028626
IDOV_2701	Virus nameAdenovirus	Virus strainAdCN205-IL12	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-12 gene	Source of cell lineShanghai cell collection	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssaySpectrophotometer	In-vitro virus concentration10 MOI	In-vitro result40% cell viability after 96 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID23028626
IDOV_2702	Virus nameAdenovirus	Virus strainAdCN205-IL12	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneNo	Virus in combination with drug/radiationVirus in combination with CIK	Immune gene insertion in viral genomeVirus expressing IL-12 gene	Source of cell lineShanghai cell collection	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssaySpectrophotometer	In-vitro virus concentration10 MOI	In-vitro result70% cell viability after 24 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID23028626
IDOV_2703	Virus nameAdenovirus	Virus strainAdCN205-IL12	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneNo	Virus in combination with drug/radiationVirus in combination with CIK	Immune gene insertion in viral genomeVirus expressing IL-12 gene	Source of cell lineShanghai cell collection	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssaySpectrophotometer	In-vitro virus concentration10 MOI	In-vitro result40% cell viability after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID23028626
IDOV_2704	Virus nameAdenovirus	Virus strainAdCN205-IL12	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneNo	Virus in combination with drug/radiationVirus in combination with CIK	Immune gene insertion in viral genomeVirus expressing IL-12 gene	Source of cell lineShanghai cell collection	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssaySpectrophotometer	In-vitro virus concentration10 MOI	In-vitro result20% cell viability after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID23028626
IDOV_2708	Virus nameAdenovirus	Virus strainAdCN205-IL12	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneNo	Virus in combination with drug/radiationVirus strain in combination with CIK (1 × 10⁷ )	Immune gene insertion in viral genomeVirus expressing IL-12 gene	Source of cell lineShanghai cell collection	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayNA	In-vitro virus concentrationNA	In-vitro resultNA	Model organismSCID mice xenograft for Huh7 (1.0E+6 cell)	In-vivo virus concentration2.0E+8 pfu	In-vivo toxicityNA	In-vivo resultReduction in tumor volume below 100mm after 40 days and increase in median survival time 40 days	Mode of deliveryIntratumoral	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID23028626
IDOV_2709	Virus nameAdenovirus	Virus strainAdCN205-IL12	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneNo	Virus in combination with drug/radiationVirus strain in combination with CIK (1 × 10⁷ )	Immune gene insertion in viral genomeVirus expressing IL-12 gene	Source of cell lineShanghai cell collection	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayNA	In-vitro virus concentrationNA	In-vitro resultNA	Model organismSCID mice xenograft for Huh7 (1.0E+6 cell)	In-vivo virus concentration2.0E+8 pfu	In-vivo toxicityNA	In-vivo resultReduction in tumor volume below 100mm after 40 days and increase in median survival time 40 days	Mode of deliveryIntravenous	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID23028626
IDOV_2747	Virus nameAdenovirus	Virus strainAdCN205	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration5 MOI	In-vitro result90% cell viability after 24 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis, G1 arrest and sensescence	Immunogenic effectInhibition of oncogene and antiapototic gene	Clinical trialNA	PMID23292172
IDOV_2748	Virus nameAdenovirus	Virus strainAdCN205	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration5 MOI	In-vitro result80% cell viability after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis, G1 arrest and sensescence	Immunogenic effectInhibition of oncogene and antiapototic gene	Clinical trialNA	PMID23292172
IDOV_2749	Virus nameAdenovirus	Virus strainAdCN205	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration5 MOI	In-vitro result60% cell viability after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis, G1 arrest and sensescence	Immunogenic effectInhibition of oncogene and antiapototic gene	Clinical trialNA	PMID23292172
IDOV_2750	Virus nameAdenovirus	Virus strainAdCN205	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration5 MOI	In-vitro result40% cell viability after 96 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis, G1 arrest and sensescence	Immunogenic effectInhibition of oncogene and antiapototic gene	Clinical trialNA	PMID23292172
IDOV_2751	Virus nameAdenovirus	Virus strainAdCN205	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneNo	Virus in combination with drug/radiationVirus strain in combination with miR-34-a	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration5 MOI	In-vitro result90% cell viability after 24 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis, G1 arrest and sensescence	Immunogenic effectInhibition of oncogene and antiapototic gene	Clinical trialNA	PMID23292172
IDOV_2752	Virus nameAdenovirus	Virus strainAdCN205	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneNo	Virus in combination with drug/radiationVirus strain in combination with miR-34-a	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration5 MOI	In-vitro result50% cell viability after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis, G1 arrest and sensescence	Immunogenic effectInhibition of oncogene and antiapototic gene	Clinical trialNA	PMID23292172
IDOV_2753	Virus nameAdenovirus	Virus strainAdCN205	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneNo	Virus in combination with drug/radiationVirus strain in combination with miR-34-a	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration5 MOI	In-vitro result30% cell viability after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis, G1 arrest and sensescence	Immunogenic effectInhibition of oncogene and antiapototic gene	Clinical trialNA	PMID23292172
IDOV_2754	Virus nameAdenovirus	Virus strainAdCN205	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneNo	Virus in combination with drug/radiationVirus strain in combination with miR-34-a	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line1.0E+4 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration5 MOI	In-vitro result20% cell viability after 96 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedInduction of apoptosis, G1 arrest and sensescence	Immunogenic effectInhibition of oncogene and antiapototic gene	Clinical trialNA	PMID23292172
IDOV_2755	Virus nameAdenovirus	Virus strainAdCN205	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneNo	Virus in combination with drug/radiationVirus strain in combination with miR-34-a	Immune gene insertion in viral genomeVirus expressing IL-24 gene	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityNA	AssayNA	In-vitro virus concentrationNA	In-vitro resultNA	Model organismBALB/c nude mice xenograft for Huh cell (2.0E+6 cell)	In-vivo virus concentration7.0E+8 pfu	In-vivo toxicityNA	In-vivo resultComplete regression in tumor volume after 49 days	Mode of deliveryIntratumoral	Pathway inducedInduction of apoptosis, G1 arrest and sensescence	Immunogenic effectInhibition of oncogene and antiapototic gene	Clinical trialNA	PMID23292172
IDOV_4299	Virus nameAlphavirus	Virus strainM1	Virus genome typeRNA	Virus familyTogaviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma	Cell lineHuh-7	Concentration of cell line4000 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 pfu	In-vitro result52.2 % cell viability after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedActivation of cAMP signalling leads to induced expression of antiviral factors, severe ER stress and cell apoptosis	Immunogenic effectNA	Clinical trialNA	PMID26373347
IDOV_4881	Virus nameAdenovirus	Virus strainAd-deltaB	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineJCRB gene bank japan	Origin of cell lineHuman hepatocellular carcinoma	Cell lineHuh-7	Concentration of cell line70% confluence on 24 well plate	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration5 MOI	In-vitro result80% cell viability after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedCombination therapy and alone promotes apoptosis	Immunogenic effectActivation of caspase-3 and 8 and upregulation of IFN-gamma	Clinical trialNA	PMID27154307
IDOV_4882	Virus nameAdenovirus	Virus strainAd-deltaB	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineJCRB gene bank japan	Origin of cell lineHuman hepatocellular carcinoma	Cell lineHuh-7	Concentration of cell line70% confluence on 24 well plate	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result60% cell viability after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedCombination therapy and alone promotes apoptosis	Immunogenic effectActivation of caspase-3 and 8 and upregulation of IFN-gamma	Clinical trialNA	PMID27154307
IDOV_4883	Virus nameAdenovirus	Virus strainAd-deltaB	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationExpressing TRAIL and IL-12 gene in under CMV promoter in deleted E3 region of virus backbone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL12 gene	Source of cell lineJCRB gene bank japan	Origin of cell lineHuman hepatocellular carcinoma	Cell lineHuh-7	Concentration of cell line70% confluence on 24 well plate	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration10 MOI	In-vitro result20% cell viability after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedCombination therapy and alone promotes apoptosis	Immunogenic effectActivation of caspase-3 and 8 and upregulation of IFN-gamma	Clinical trialNA	PMID27154307
IDOV_4884	Virus nameAdenovirus	Virus strainAd-deltaB	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationExpressing TRAIL and IL-12 gene in under CMV promoter in deleted E3 region of virus backbone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeVirus expressing IL12 gene	Source of cell lineJCRB gene bank japan	Origin of cell lineHuman hepatocellular carcinoma	Cell lineHuh-7	Concentration of cell line70% confluence on 24 well plate	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration20 MOI	In-vitro result10% cell viability after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedCombination therapy and alone promotes apoptosis	Immunogenic effectActivation of caspase-3 and 8 and upregulation of IFN-gamma	Clinical trialNA	PMID27154307
IDOV_5214	Virus nameAdenovirus	Virus strainwild type	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineJCRB cell bank	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityToxic to normal human cell line above 10 MOI	AssayAlamar blue assay	In-vitro virus concentration2 MOI	In-vitro result100% cell viable after 24 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27760834
IDOV_5215	Virus nameAdenovirus	Virus strainwild type	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineJCRB cell bank	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityToxic to normal human cell line above 10 MOI	AssayAlamar blue assay	In-vitro virus concentration2 MOI	In-vitro result100% cell viable after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27760834
IDOV_5216	Virus nameAdenovirus	Virus strainwild type	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineJCRB cell bank	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityToxic to normal human cell line above 10 MOI	AssayAlamar blue assay	In-vitro virus concentration2 MOI	In-vitro result80% cell viable after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27760834
IDOV_5217	Virus nameAdenovirus	Virus strainTRAD-shLuc	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationVirus having shorthairpin RNA for Luciferase gene knockout	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineJCRB cell bank	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityToxic to normal human cell line above 10 MOI	AssayAlamar blue assay	In-vitro virus concentration2 MOI	In-vitro result100% cell viable after 24 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27760834
IDOV_5218	Virus nameAdenovirus	Virus strainTRAD-shLuc	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationVirus having shorthairpin RNA for Luciferase gene knockout	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineJCRB cell bank	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityToxic to normal human cell line above 10 MOI	AssayAlamar blue assay	In-vitro virus concentration2 MOI	In-vitro result100% cell viable after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27760834
IDOV_5219	Virus nameAdenovirus	Virus strainTRAD-shLuc	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationVirus having shorthairpin RNA for Luciferase gene knockout	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineJCRB cell bank	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityToxic to normal human cell line above 10 MOI	AssayAlamar blue assay	In-vitro virus concentration2 MOI	In-vitro result80% cell viable after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27760834
IDOV_5220	Virus nameAdenovirus	Virus strainTRAD-shDICER	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationVirus having shorthairpin RNA for DICER	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineJCRB cell bank	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityToxic to normal human cell line above 10 MOI	AssayAlamar blue assay	In-vitro virus concentration2 MOI	In-vitro result100% cell viable after 24 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27760834
IDOV_5221	Virus nameAdenovirus	Virus strainTRAD-shDICER	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationVirus having shorthairpin RNA for DICER	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineJCRB cell bank	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityToxic to normal human cell line above 10 MOI	AssayAlamar blue assay	In-vitro virus concentration2 MOI	In-vitro result80% cell viable after 48 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27760834
IDOV_5222	Virus nameAdenovirus	Virus strainTRAD-shDICER	Virus genome typeDNA	Virus familyAdenoviridae	Virus genome modificationVirus having shorthairpin RNA for DICER	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineJCRB cell bank	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell lineNA	In-vitro toxicityToxic to normal human cell line above 10 MOI	AssayAlamar blue assay	In-vitro virus concentration2 MOI	In-vitro result20% cell viable after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedNA	Immunogenic effectNA	Clinical trialNA	PMID27760834
IDOV_5340	Virus nameNewcastle disease virus	Virus strainLaSota	Virus genome typeRNA	Virus familyParamyxoviridae	Virus genome modificationNone	Virus aloneYes	Virus in combination with drug/radiationNo	Immune gene insertion in viral genomeNo	Source of cell lineATCC	Origin of cell lineHuman hepatocellular carcinoma cell line	Cell lineHuh-7	Concentration of cell line5.0E+4 cells per well	In-vitro toxicityNA	AssayMTT assay	In-vitro virus concentration0.001 MOI	In-vitro result37% cells remain viable after 72 hours	Model organismNo	In-vivo virus concentrationNo	In-vivo toxicityNA	In-vivo resultNo response	Mode of deliveryNA	Pathway inducedVirus induce apoptosis	Immunogenic effectInduced production of IFN-alpha, IFN-beta, IL-6and IFN-gamma	Clinical trialNA	PMID28293547