The total number record retrieved from this search are 100. Click on ID to see further detail.

ID	Virus name	Virus strain	Virus genome type	Virus family	Virus genome modification	Virus alone	Virus in combination with drug/radiation	Immune gene insertion in viral genome	Source of cell line	Origin of cell line	Cell line	Concentration of cell line	In-vitro toxicity	Assay	In-vitro virus concentration	In-vitro result	Model organism	In-vivo virus concentration	In-vivo toxicity	In-vivo result	Mode of delivery	Pathway induced	Immunogenic effect	Clinical trial	PMID
OV_314	Adenovirus	Ad.sp-E1A	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP)	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	0.5 MOI	28% cancer cell viability at 96 hours	No	No	NA	No response	NA	NA	NA	NA	26554307
OV_315	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	0.5 MOI	78% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_316	Adenovirus	Ad.4N1-IL24	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettes	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	0.5 MOI	24% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_317	Adenovirus	Ad.sp-E1A	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP)	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	1 MOI	24% cancer cell viability at 96 hours	No	No	NA	No response	NA	NA	NA	NA	26554307
OV_318	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	1 MOI	57% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_319	Adenovirus	Ad.4N1-IL24	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettes	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	1 MOI	18% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_320	Adenovirus	Ad.sp-E1A	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP)	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	2 MOI	22% cancer cell viability at 96 hours	No	No	NA	No response	NA	NA	NA	NA	26554307
OV_321	Adenovirus	Ad.4N1	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 expression cassette	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	2 MOI	45% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_322	Adenovirus	Ad.4N1-IL24	DNA	Adenoviridae	Viral E1A promoter was replaced by human survivin promoter (hsurP) and contains a sCAR-4N1 with IL-24 expression cassettes	Yes	No	No	ATCC	Human lung cancer cell line	A549	NA	NA	MTT assay	2 MOI	11% cancer cell viability at 96 hours	No	No	NA	No response	NA	Induces apoptosis by upregulating Bax and activated caspase 3 levels	Induces expression of IL-24	NA	26554307
OV_345	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	10 MOI	58% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_346	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	H441	2.5E+4 cells per well	NA	MTT assay	10 MOI	62% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_347	Adenovirus	AdLacZ	DNA	Adenoviridae	E1/E3-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	Calu1	2.5E+4 cells per well	NA	MTT assay	10 MOI	74% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_348	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) - 0.6 mM	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	2.5 MOI	18% cancer cell viability	No	No	NA	No response	NA	JNK activation induces autophagy	NA	NA	26561948
OV_349	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) - 0.75 mM	No	ATCC	Human lung cancer cell line	H441	2.5E+4 cells per well	NA	MTT assay	20 MOI	22% cancer cell viability	No	No	NA	No response	NA	JNK activation induces autophagy	NA	NA	26561948
OV_350	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) - 1 mM	No	ATCC	Human lung cancer cell line	Calu1	2.5E+4 cells per well	NA	MTT assay	10 MOI	12% cancer cell viability	No	No	NA	No response	NA	JNK activation induces autophagy	NA	NA	26561948
OV_351	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	10 MOI	49% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_352	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	Yes	No	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	10 MOI	26% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	26561948
OV_353	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) and 3-MA at -0.75 mM and 10 mM concentration, respectively	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	10 MOI	62% cancer cell viability	No	No	NA	No response	NA	JNK activation induces autophagy (Autophagy effect slightly inhibited by 3-MA)	NA	NA	26561948
OV_354	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) and 3-MA at -0.75 mM and 10 mM concentration, respectively	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	10 MOI	44% cancer cell viability	No	No	NA	No response	NA	JNK activation induces autophagy (Autophagy effect slightly inhibited by 3-MA)	NA	NA	26561948
OV_355	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) and BAF-A1 at -0.75 mM and 10 nM concentration, respectively	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	10 MOI	65% cancer cell viability	No	No	NA	No response	NA	JNK activation induces autophagy (Autophagy effect slightly inhibited by Baf-A1)	NA	NA	26561948
OV_356	Adenovirus	Adhz60	DNA	Adenoviridae	E1b-deleted mutant	No	Virus in combination with temozolomide (TMZ) and BAF-A1 at -0.75 mM and 10 nM concentration, respectively	No	ATCC	Human lung cancer cell line	A549	2.5E+4 cells per well	NA	MTT assay	10 MOI	47% cancer cell viability	No	No	NA	No response	NA	JNK activation induces autophagy (Autophagy effect slightly inhibited by Baf-A1)	NA	NA	26561948
OV_568	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with PKA catalytic subunit siRNA and scramble siRNA (siPKA-1)	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	NA	MTT assay	10 PFU/cell	62% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	NA	NA	27374176
OV_569	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with PKA catalytic subunit siRNA and scramble siRNA (siPKA-2)	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	NA	MTT assay	10 PFU/cell	57% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	NA	NA	27374176
OV_570	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with PKA catalytic subunit siRNA and scramble siRNA (siPKA-3)	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	NA	MTT assay	10 PFU/cell	65% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	NA	NA	27374176
OV_571	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	NA	MTT assay	10 PFU/cell	50% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_572	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	0.001 PFU/cell	70% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_573	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	0.001 PFU/cell	100% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_574	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	0.01 PFU/cell	39% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_575	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	0.01 PFU/cell	100% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_576	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	0.1 PFU/cell	22% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_577	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	0.1 PFU/cell	92% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_578	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	1 PFU/cell	20% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_579	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	1 PFU/cell	80% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_580	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	10 PFU/cell	20% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_581	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	10 PFU/cell	75% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_582	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	0.001 PFU/cell	86% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_583	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	0.001 PFU/cell	100% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_584	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	0.01 PFU/cell	80% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_585	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	0.01 PFU/cell	100% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_586	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	0.1 PFU/cell	70% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_587	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	0.1 PFU/cell	100% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_588	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	1 PFU/cell	38% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_589	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	1 PFU/cell	90% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_590	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with H89(10 μM) for 1 hour	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	10 PFU/cell	25% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_591	Alphavirus	M1	RNA	Togaviridae	None	Yes	No	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	Non toxic to human immortalized liver cell line L-02	MTT assay	10 PFU/cell	80% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_592	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with small interfering RNA (siRNAs) against Epac1 (siEpac1001)	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	10 PFU/cell	100% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_593	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with small interfering RNA (siRNAs) against Epac1 (siEpac1002)	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	10 PFU/cell	70% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_594	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with small interfering RNA (siRNAs) against Epac1 (siEpac1003)	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	10 PFU/cell	90% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	NA	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_595	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with small interfering RNA (siRNAs) against Epac1 (siEpac1001) and with H89(10 μM)	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	10 PFU/cell	60% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_596	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with small interfering RNA (siRNAs) against Epac1 (siEpac1002) and with H89(10 μM)	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	10 PFU/cell	45% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_597	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with small interfering RNA (siRNAs) against Epac1 (siEpac1003) and with H89(10 μM)	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	Very small toxicity towards human immortalized liver cell line L-02	MTT assay	10 PFU/cell	75% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	JNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_598	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with ESI-09 and with H89(10 μM)	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	NA	MTT assay	0.1 PFU/cell	60% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	ESI-09 abrogates the activities of Caspase-3/9/8 induced by H89/M1 combination treatment.	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_599	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with ESI-09	No	ATCC	Human colorectal carcinoma cell line	HCT-116	4000 cells per well	NA	MTT assay	0.1 PFU/cell	80% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	ESI-09 abrogates the activities of Caspase-3/9/8 induced by H89/M1 combination treatment.	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_600	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with ESI-09 and with H89(10 μM)	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	NA	MTT assay	0.1 PFU/cell	75% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	ESI-09 abrogates the activities of Caspase-3/9/8 induced by H89/M1 combination treatment.	M1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89	NA	27374176
OV_601	Alphavirus	M1	RNA	Togaviridae	None	No	Viral strain in combination with ESI-09	No	ATCC	Human pancreatic ductal adenocarcinoma cell line	Capan-1	4000 cells per well	NA	MTT assay	0.1 PFU/cell	82% cancer cell viability at 72 hours post-infection	No	No	NA	No response	NA	ESI-09 abrogates the activities of Caspase-3/9/8 induced by H89/M1 combination treatment.	M1 upregulated transcriptional ISGs (329 shown here)	NA	27374176
OV_606	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	Key Laboratory of Zoonosis, Jilin University	Human prostate cancer cell line	PC-3M	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	70% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_607	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	ATCC	Human cervical cancer cell	HeLa	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	85% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_608	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	ATCC	Human bone osteosarcoma epithelial cell line	U2OS (telomerase-negative)	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	96% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_609	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	Key Laboratory of Zoonosis, Jilin University	Human prostate cancer cell line	PC-3M	1.0E+5 cells per well	NA	MTT assay	1 MOI	40% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_610	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	ATCC	Human cervical cancer cell	HeLa	1.0E+5 cells per well	NA	MTT assay	1 MOI	37% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_611	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	ATCC	Human bone osteosarcoma epithelial cell line	U2OS (telomerase-negative)	1.0E+5 cells per well	NA	MTT assay	1 MOI	94% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_612	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	Key Laboratory of Zoonosis, Jilin University	Human prostate cancer cell line	PC-3M	1.0E+5 cells per well	NA	MTT assay	10 MOI	18% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_613	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	ATCC	Human cervical cancer cell	HeLa	1.0E+5 cells per well	NA	MTT assay	10 MOI	8% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_614	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	ATCC	Human bone osteosarcoma epithelial cell line	U2OS (telomerase-negative)	1.0E+5 cells per well	NA	MTT assay	10 MOI	92% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_615	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	Key Laboratory of Zoonosis, Jilin University	Human prostate cancer cell line	PC-3M	1.0E+5 cells per well	NA	MTT assay	50 MOI	10% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_616	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	ATCC	Human cervical cancer cell	HeLa	1.0E+5 cells per well	NA	MTT assay	50 MOI	5% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_617	Adenovirus	CRAd-CCL21-IL15	DNA	Adenoviridae	Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells	Yes	No	IL-15	ATCC	Human bone osteosarcoma epithelial cell line	U2OS (telomerase-negative)	1.0E+5 cells per well	NA	MTT assay	50 MOI	90% cancer cell viability	No	No	NA	No response	NA	NA	NA	NA	27380620
OV_619	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	77% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_620	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	77% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_621	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	52% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_622	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	48% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_623	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	1 MOI	40% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_624	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	60% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_625	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	50% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_626	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	48% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_627	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	40% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_628	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	A375	1.0E+5 cells per well	NA	MTT assay	1 MOI	38% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_629	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	120% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_630	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	110% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_631	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	60% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_632	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	40% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_633	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	1 MOI	30% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_634	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	110% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_635	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_636	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	58% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_637	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	25% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_638	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	DO4	1.0E+5 cells per well	NA	MTT assay	1 MOI	25% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_639	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	105% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_640	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	107% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_641	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	90% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_642	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	70% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_643	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	1 MOI	61% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_644	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	90% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_645	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	93% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_646	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (antagonism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	87% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_647	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	0.5 MOI	58% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_648	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 5 Gy (synergism)	No	Prof. Richard Marais lab	Human melanoma cell line	MeWo	1.0E+5 cells per well	NA	MTT assay	1 MOI	59% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_649	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.001 MOI	111% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_650	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.01 MOI	102% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486
OV_651	Reovirus	RT3D (Reolysin)	RNA	Reoviridae	None	No	Viral strain in combination with radiation, 3 Gy (synergism)	No	Prof. Richard Marais lab	Human malignant melanoma cell line	Mel624	1.0E+5 cells per well	NA	MTT assay	0.1 MOI	98% cancer cell viability (calculated as relative to non-infected group)	No	No	NA	No response	NA	Down-regulation of the inhibitor of apoptosis (IAP) family of proteins with a corresponding increase in cleaved caspase 9/3	NA	NA	27384486