Detailed description page of Selected OV_ID


OV_595 details
Primary information
OV_IDOV_595
Virus Name Alphavirus
StrainM1
Virus typeRNA
Virus familyTogaviridae
Modification in virus genomeNone
Virus aloneNo
Virus in combination iwth drug/radiationViral strain in combination with small interfering RNA (siRNAs) against Epac1 (siEpac1001) and with H89(10 μM)
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman colorectal carcinoma cell line
Cell lineHCT-116
Concentration of cell line4000
In-vitro toxicityVery small toxicity towards human immortalized liver cell line L-02
AssayMTT assay
In-vitro virus concentration10 PFU/cell
In-vitro result60% cancer cell viability at 72 hours post-infection
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionJNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated
Immunogenic effectM1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89
Clinical trialNA
PMID27374176