Detailed description page of Selected OV_ID


OV_588 details
Primary information
OV_IDOV_588
Virus Name Alphavirus
StrainM1
Virus typeRNA
Virus familyTogaviridae
Modification in virus genomeNone
Virus aloneNo
Virus in combination iwth drug/radiationViral strain in combination with H89(10 μM) for 1 hour
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman pancreatic ductal adenocarcinoma cell line
Cell lineCapan-1
Concentration of cell line4000
In-vitro toxicityVery small toxicity towards human immortalized liver cell line L-02
AssayMTT assay
In-vitro virus concentration1 PFU/cell
In-vitro result38% cancer cell viability at 72 hours post-infection
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionJNK, mitochondrial apoptotic pathway, Caspase-3/7, Caspase-9 and Caspase-8 (active caspases activates downstream apoptotic pathway) are activated
Immunogenic effectM1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89
Clinical trialNA
PMID27374176