| Primary information |
|---|
| OV_ID | OV_615 |
| Virus Name | Adenovirus |
| Strain | CRAd-CCL21-IL15 |
| Virus type | DNA |
| Virus family | Adenoviridae |
| Modification in virus genome | Insertion mutant for CCL21 and IL15 genes with TERTp to target the TERT-positive cancer cells |
| Virus alone | Yes |
| Virus in combination iwth drug/radiation | No |
| Immune gene induction in virus genome | IL-15 |
| Source of cell line | Key Laboratory of Zoonosis, Jilin University |
| Origin of cell line | Human prostate cancer cell line |
| Cell line | PC-3M |
| Concentration of cell line | 1 |
| In-vitro toxicity | NA |
| Assay | MTT assay |
| In-vitro virus concentration | 50 MOI |
| In-vitro result | 10% cancer cell viability |
| Model organism | No |
| In-vivo virus concentration | No |
| In-vivo toxicity | NA |
| In-vivo result | No response |
| Mode of delivery | NA |
| Pathway induction | NA |
| Immunogenic effect | NA |
| Clinical trial | NA |
| PMID | 27380620 |