Detailed description page of Selected OV_ID


OV_598 details
Primary information
OV_IDOV_598
Virus Name Alphavirus
StrainM1
Virus typeRNA
Virus familyTogaviridae
Modification in virus genomeNone
Virus aloneNo
Virus in combination iwth drug/radiationViral strain in combination with ESI-09 and with H89(10 μM)
Immune gene induction in virus genomeNo
Source of cell lineATCC
Origin of cell lineHuman colorectal carcinoma cell line
Cell lineHCT-116
Concentration of cell line4000
In-vitro toxicityNA
AssayMTT assay
In-vitro virus concentration0.1 PFU/cell
In-vitro result60% cancer cell viability at 72 hours post-infection
Model organismNo
In-vivo virus concentrationNo
In-vivo toxicityNA
In-vivo resultNo response
Mode of deliveryNA
Pathway inductionESI-09 abrogates the activities of Caspase-3/9/8 induced by H89/M1 combination treatment.
Immunogenic effectM1 upregulated transcriptional ISGs (329 shown here) were inhibited by H89
Clinical trialNA
PMID27374176