| 1094 | HLA-A2 (60-84) | FDSDAASQRMEPRAPWIEQEGPEYW | 25 | L | None | None | None | Linear | Protein Derived | MHC molecule | NA | NA | Both | NA | NA | LEW rat | Graft transplation assay | NA | NA | 8573307 | 1995 |
| 1142 | RDP1258 | RNleNleNleRNleNleNleGY | 22 | L | None | Amidation | None | Linear | Protein Derived | NA | TNF-α | Enhanced expression of splenic heme oxygenase 1 (HO-1). Decreased expression of tumor necrosis factor a (TNF-α) mRNA; and an increased level of inducible nitric oxide synthase (iNOS) mRNA. | In vivo | NA | 20 micromolar | Eight- to 12-week-old male Lewis.lW (RTI.u) and Lewis.lA (RTI.')rats | Graft transplation assay | NA | NA | 10666482 | 2000 |
| 1164 | HIV-env 586-606 | RILAVERYLKDQQLLGIWGCS | 21 | L | None | None | None | Linear | Synthetic | NA | NA | Not Available | In vitro | Human sera | NA | NA | NA | NA | NA | 2455899 | 1988 |
| 1213 | SEQ ID NO: 2 | AEHRLREEILAKFLHWLMSVYVVEL | 25 | L | None | None | None | Linear | Protein Derived | human telomerase reverse transcriptase | Proteasome | Inhibits the overall activity of the proteasome | In vitro | HeLa, Saos | NA | NA | NA | NA | NA | DE 102006025146 A1 | 2007 |
| 1215 | SEQ ID NO: 4 | RLMYDILAKFLHWLGPSEKRVWMS | 24 | L | None | None | None | Linear | Protein Derived | human telomerase reverse transcriptase | Proteasome | Inhibits the overall activity of the proteasome | In vitro | HeLa, Saos | NA | NA | NA | NA | NA | DE 102006025146 A1 | 2007 |
| 1221 | Aalpha (SEQ ID NO 12) | ERHQSACKDSDWPFCSDEDWNYK | 23 | L | None | None | None | Linear | Protein Derived | Alpha chain of the fibrin | Lymphocyte | Suppress increase in inflammatory cells, Aalpha Gly Pro Arg (Pro) - NH 2 acetate (Aalpha derivative) short peptide is equally effective as the long peptides in appropriate continuous addition at inhibiting monocyte migration | In vivo | PBMC | NA | HU-SCID mouse model | NA | NA | NA | WO 2002048180 A2 | 2002 |
| 1222 | Bbeta (SEQ ID NO 11) | DKRKEEAPSLRPAPPPISGGGYR | 23 | L | None | None | None | Linear | Protein Derived | Beta chain of the fibrin | Lymphocyte | Inhibition of Lymphocyte migration, blocks the lymphocytic inflammation, Bbeta Gly His Arg Pro-OH acetate (Bbeta derivative) short peptide is equally effective as the long peptides in appropriate continuous addition at inhibiting monocyte migration | In vivo | PBMC | NA | HU-SCID mouse model | NA | NA | NA | WO 2002048180 A2 | 2002 |
| 1317 | CS-22 | GLDLLFLKEGGLCAALKEECCF | 22 | L | None | None | None | Linear | Protein Derived | Retrovial envelope protein | Human Monocytes | Inhibit CTLL-2 proliferation | Both | Human mononuclear cells, Murine CTLL-2 cells, Balb/3T3 cells, NIH/3T8 | NA | BALB/c and NIH/Swiss mice, Rabbits | Hummoral Immune Response assay, Monocytes O2 release assay | NA | BSA | US 4822606 | 1989 |
| 1318 | HTLV-I | GLDLLFWEQGGLCKALQEQCRF | 22 | L | None | None | None | Linear | Protein Derived | Human T-cell Leukemia Virus envelope proteins | Human Monocytes | Inhibit CTLL-2 proliferation | Both | Human mononuclear cells, Murine CTLL-2 cells, Balb/3T3 cells, NIH/3T9 | NA | BALB/c and NIH/Swiss mice, Rabbits | Hummoral Immune Response assay, Monocytes O2 release assay | NA | BSA | US 4822606 | 1989 |
| 1319 | HTLV-II | GLDLLFWEQGGLCKAIQEQCCF | 22 | L | None | None | None | Linear | Protein Derived | Human T-cell Leukemia Virus envelope proteins | Human Monocytes | Inhibit CTLL-2 proliferation | Both | Human mononuclear cells, Murine CTLL-2 cells, Balb/3T3 cells, NIH/3T10 | NA | BALB/c and NIH/Swiss mice, Rabbits | Hummoral Immune Response assay, Monocytes O2 release assay | NA | BSA | US 4822606 | 1989 |
| 1320 | Feline | GLDILFLQEGGLCAALKEECCF | 22 | L | None | None | None | Linear | Protein Derived | Feline virus envelope proteins | Human Monocytes | Inhibit CTLL-2 proliferation | Both | Human mononuclear cells, Murine CTLL-2 cells, Balb/3T3 cells, NIH/3T11 | NA | BALB/c and NIH/Swiss mice, Rabbits | Hummoral Immune Response assay, Monocytes O2 release assay | NA | BSA | US 4822606 | 1989 |
| 1321 | Endog-22 | ALDYLLAAEGGVCGKFNLTQYC | 22 | L | None | None | None | Linear | Protein Derived | Retrovial envelope protein | Human Monocytes | Inhibit CTLL-2 proliferation | Both | Human mononuclear cells, Murine CTLL-2 cells, Balb/3T3 cells, NIH/3T12 | NA | BALB/c and NIH/Swiss mice, Rabbits | Hummoral Immune Response assay, Monocytes O2 release assay | NA | BSA | US 4822606 | 1989 |
| 1322 | None | GLDLLTAEQGGICLALQEKCCF | 22 | L | None | None | None | Linear | Protein Derived | Retrovial envelope protein | Human Monocytes | Inhibit CTLL-2 proliferation | Both | Human mononuclear cells, Murine CTLL-2 cells, Balb/3T3 cells, NIH/3T13 | NA | BALB/c and NIH/Swiss mice, Rabbits | Hummoral Immune Response assay, Monocytes O2 release assay | NA | BSA | US 4822606 | 1989 |
| 1334 | None | QNRLDYLLAAEGGVCGKFNLTNYC | 24 | L | None | None | None | Linear | Protein Derived | Retrovial envelope protein | Human Monocytes | Inhibit CTLL-2 proliferation | Both | Human mononuclear cells, Murine CTLL-2 cells, Balb/3T3 cells, NIH/3T25 | NA | BALB/c and NIH/Swiss mice, Rabbits | Hummoral Immune Response assay, Monocytes O2 release assay | NA | BSA | US 4822606 | 1989 |
| 1335 | None | QARILAVERYLDQQLLGIWGCSGKL | 25 | L | None | None | Coupled with carrier protein human serum albumin, bovine serum albumin | Linear | Protein Derived | Retrovial envelope protein | Human Monocytes | Inhibit CTLL-2 proliferation | Both | Human mononuclear cells, Murine CTLL-2 cells, Balb/3T3 cells, NIH/3T26 | NA | BALB/c and NIH/Swiss mice, Rabbits | Hummoral Immune Response assay, Monocytes O2 release assay | NA | BSA | US 4822606 | 1989 |
| 1360 | CDP2 | GE(HP)GA(HP)GPAGP(HP)GE(HP)GA(HP)GPAG | 22 | L | None | None | HP = Hydroxyproline | Linear | Protein Derived | Collagen derived | Bystander antigens | By releasing transforming growth factor β (TGF-β) | In vivo | None | NA | Rats | NA | NA | NA | US 5399347 | 1995 |
| 1361 | CDP3 | GEEGLRGARGE(HP)GERGP(HP)GPQGAR | 24 | L | None | None | HP = Hydroxyproline | Linear | Protein Derived | Collagen derived | Bystander antigens | By releasing transforming growth factor β (TGF-β) | In vivo | None | NA | Rats | NA | NA | NA | US 5399347 | 1995 |
| 1362 | CDP2 | GE(HP)GA(HP)GPAGP(HP)GE(HP)GA(HP)GpAGp(HP)G | 25 | Mix | None | None | HP = Hydroxyproline | Linear | Protein Derived | Collagen derived | Bystander antigens | By releasing transforming growth factor β (TGF-β) | In vivo | None | NA | Rats | NA | NA | NA | US 5720955 | 1998 |
| 1363 | CDP3 | GEEGLRGARGE(HP)GERGP(HP)GPQGA | 23 | L | None | None | HP = Hydroxyproline | Linear | Protein Derived | Collagen derived | Bystander antigens | By releasing transforming growth factor β (TGF-β) | In vivo | None | NA | Rats | NA | NA | NA | US 5720955 | 1998 |
| 1365 | CDP2 | GE(HP)GA(HP)GPAGP(HP)GE(HP)GA(HP)GPAGP(HP)G | 25 | L | None | None | HP = Hydroxyproline | Linear | Protein Derived | Collagen derived | Bystander antigens | By releasing transforming growth factor β (TGF-β) | In vivo | None | NA | Rats | NA | NA | NA | US 5783188 | 1998 |
| 1366 | CDP3 | GEEGLRGARGE(HP)GERGP(HP)GPQGAR | 24 | L | None | None | HP = Hydroxyproline | Linear | Protein Derived | Collagen derived | Bystander antigens | By releasing transforming growth factor β (TGF-β) | In vivo | None | NA | Rats | NA | NA | NA | US 5783188 | 1998 |
| 1368 | CDP2 | GE(HP)GA(HP)GPAGP(HP)GE(HP)GA(HP)GPAGP(HP)G | 25 | L | None | None | HP = Hydroxyproline | Linear | Protein Derived | Collagen derived | Bystander antigens | By releasing transforming growth factor β (TGF-β) | In vivo | None | NA | Rats | NA | NA | NA | US 5843445 | 1998 |
| 1369 | CDP3 | GEEGLRGARGE(HP)GERGP(HP)GPQGAR | 24 | L | None | None | HP = Hydroxyproline | Linear | Protein Derived | Collagen derived | Bystander antigens | By releasing transforming growth factor β (TGF-β) | In vivo | None | NA | Rats | NA | NA | NA | US 5843445 | 1998 |
| 1374 | Nef2-19 | GGKWSKSSVIGWPAVRERMRR | 21 | L | None | None | None | Linear | Natural | NL4.3 strain of HIV-1 | T -cells | Downregulates CD4 and IL-2 | In vitro | MT-2 cells | NA | None | Electroporation technique | NA | GST | US 5962635 | 1999 |
| 1435 | Nef2-19 | GGKWSKSSVIGWPAVRERMRR | 21 | L | None | None | None | Linear | Natural | NL4.3 strain of HIV-1 | T -cells | Downregulates CD4 and IL-2 | In vitro | CD4+ T-cell lines, PBMC, MT-2 cells, Jurkat cells | NA | None | Hummoral Immune Response assay | NA | NA | US 6197583 B1 | 2001 |
| 1522 | Peptide 131-151 | RIHMVYSKRSGKPRGYAFIEY | 21 | L | None | None | None | Linear | Protein Derived | Spliceosomal U1-70K protein | HLA class II molecules | IL-10 secretion | In vivo | NA | NA | MRL/lpr mice | HLA-DR peptide-binding assay, ELISA, CFSE, PBMC Proliferation assay | NA | lupus | 16237076 | 2005 |
| 1523 | Peptide 131-151 P140 | RIHMVYSKRS(P)GKPRGYAFIEY | 21 | L | None | None | phosphorylation at Ser140 | Linear | Protein Derived | Spliceosomal U1-70K protein | HLA class II molecules | IL-10 secretion | In vivo | NA | NA | MRL/lpr mice | HLA-DR peptide-binding assay, ELISA, CFSE, PBMC Proliferation assay | NA | lupus | 16237076 | 2005 |
| 1526 | A12 | GEBGIAGNKGDQGPKGEBGPA | 21 | L | None | None | None | Linear | Protein Derived | Type II collagen | T-cells | Decrease in IFN-γ and increase in IL-4 production | In vivo | NA | NA | DR4 transgenic Mice | ELISA, Class II binding assay, Proliferation assay | NA | NA | 16982003 | 2006 |
| 1531 | PLP-BPI | HSLGKWLGHPDKF-AcGAcGAc-ITDGEATDSG | 23 | L | None | None | Chemical linker AcGAcGAc, where Ac is ε- aminicaproic acid | Linear | Synthetic | Proteolipid protein (PLP) and bifunctional peptide inhibitor (BPI) | Regulatory T-Cell | Increase in CD4+ CD25+TGF-β+ , CD4 +CD25+ IL-4+ ,and CD4+ CD25+ IL-10 + T cells also CD4+ CD25+ IFN-γ+ cells | In vivo | NA | NA | SJL/J (H-2s) female mice | NA | NA | NA | 17522343 | 2007 |
| 1533 | MOG peptide | MEVGWYRSPFSRVVHLYRNGK | 21 | L | None | None | None | Linear | Protein Derived | Myelin oligodendrocyte glycoprotein | IL-10, TGF-β | Not Available | In vivo | NLDC-145 for DEC205 and GL117 for b-galactosidase | NA | C57/Bl6 mice, 2D2 mice or BALB/c mice | Proliferation assay | NA | NA | 23945139 | 2013 |
| 1535 | MOG35-55 | MEVGWYRSPFSRVVHLYRNGK | 21 | L | None | None | None | Linear | Protein Derived | Myelin oligodendrocyte glycoprotein | IL-10, TGF-β1, FoxP3 | Not Available | Both | splenocytes | NA | C57BL/6 mice | Proliferation assay | NA | NA | 23077616 | 2012 |
| 1538 | ApoB peptide | CIEIGLEGKGFEPTLEALFGK | 21 | L | None | None | None | Linear | Protein Derived | Apolipoprotein B100 (ApoB) | IL-10, TGF-β | Induced T-cell proliferation and expansion of regulatory T cells | Both | Splenocytes, Dendritic Cells | NA | C57BL6/J | Cytometric bead assay | NA | NA | 23400302 | 2013 |
| 1541 | MOG35-55 peptide | MEVGWYRSPFSRVVHLYRNGK | 21 | L | None | None | None | Linear | Protein Derived | Myelin oligodendrocyte glycoprotein | IL-10 | Not Available | Both | Spleen cells | NA | C57BL/6 and IL-10-/-(B6.129P2-Il10tmlCgn/J) mice | Proliferation assay | NA | NA | 20624940 | 2010 |
| 1543 | MOG35-55 peptide | MEVGWYRSPFSRVVHLYRNGK | 21 | L | None | None | None | Linear | Protein Derived | Myelin oligodendrocyte glycoprotein | IL-10 | Not Available | Both | Spleen and lymph node cells | NA | C57BL/6 mice | Bio-Plex Cytokine Assay | NA | NA | 23033382 | 2012 |
| 1545 | H471 | TYTEHAKRKTVTAMDVVYALKRQ | 23 | L | None | None | None | Linear | Protein Derived | Histone H4 protein | T-cell epitope of histone protein H4 of mononucleosome | Producing large amount of IL-10 and decreasing IFN-gamma by lymph node cells | Both | LN cells | NA | Lupus prone SNF1 female mice | ELISA, Cell Proliferation Assay, Ce1ELISA | NA | CFA | 12097422 | 2002 |
| 1546 | CII(256-276, N263, D266) | GEBGIAGFKGEQGPKGEBGA | 21 | L | None | None | None | Linear | Protein Derived | Type II Collagen | Spleen and Lymph node | Produce large amount of IL-4. | in vivo | None | NA | HLA-DR1 Transgenic mice, C57BL/6 IL-4 knockout mice | Class II binding assay, ELISA | NA | NA | 12483744 | 2002 |
| 1550 | R9-SOCS1-KIR | RRRRRRRRRDTH-FRTFRSHSDYRRI | 25 | L | None | None | None | Linear | Protein Derived | kinase inhibitory region (KIR) of the intracellular checkpoint protein suppressor of cytokine signaling 1 (SOCS-1 | phospho-tyrosine containing regions of the tyrosine kinases JAK2 and TYK2 and the adaptor protein MAL | By blocking the inflammtory effects of IFN-γ, TNF-α or IL-17A. | Both | ARPE-19 cell | NA | B10. RIII mice | immunohistochemistry | NA | NA | 30048621 | 2018 |
