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1142 details |
| Primary information | |
|---|---|
| ID | 1142 |
| Peptide Name | RDP1258 |
| Sequence | RNleNleNleRNleNleNleGY |
| Length | 22 |
| Chirality | L |
| N-terminal Modification | None |
| C-terminal Modification | Amidation |
| Chemical Modification | None |
| Linear/ Cyclic | Linear |
| Nature | Protein Derived |
| Source of Origin | NA |
| Target | TNF-α |
| Mechanism of Action | Enhanced expression of splenic heme oxygenase 1 (HO-1). Decreased expression of tumor necrosis factor a (TNF-α) mRNA; and an increased level of inducible nitric oxide synthase (iNOS) mRNA. |
| In vitro/In vivo | In vivo |
| Cell Line | NA |
| Inhibition Concentartion | 20 micromolar |
| In vivo Model | Eight- to 12-week-old male Lewis.lW (RTI.u) and Lewis.lA (RTI.')rats |
| Assay | Graft transplation assay |
| Lethal Dose | NA |
| Combination Therapy | NA |
| Pubmed ID | 10666482 |
| Year of Publication | 2000 |
| 3-D Structure | NA |