Primary information |
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ID | 1531 |
Peptide Name | PLP-BPI |
Sequence | HSLGKWLGHPDKF-AcGAcGAc-ITDGEATDSG |
Length | 23 |
Chirality | L |
N-terminal Modification | None |
C-terminal Modification | None |
Chemical Modification | Chemical linker AcGAcGAc, where Ac is ε- aminicaproic acid |
Linear/ Cyclic | Linear |
Nature | Synthetic |
Source of Origin | Proteolipid protein (PLP) and bifunctional peptide inhibitor (BPI) |
Target | Regulatory T-Cell |
Mechanism of Action | Increase in CD4+ CD25+TGF-β+ , CD4 +CD25+ IL-4+ ,and CD4+ CD25+ IL-10 + T cells also CD4+ CD25+ IFN-γ+ cells |
In vitro/In vivo | In vivo |
Cell Line | NA |
Inhibition Concentartion | NA |
In vivo Model | SJL/J (H-2s) female mice |
Assay | NA |
Lethal Dose | NA |
Combination Therapy | NA |
Pubmed ID | 17522343 |
Year of Publication | 2007 |
3-D Structure | NA |