Primary information |
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ID | 1550 |
Peptide Name | R9-SOCS1-KIR |
Sequence | RRRRRRRRRDTH-FRTFRSHSDYRRI |
Length | 25 |
Chirality | L |
N-terminal Modification | None |
C-terminal Modification | None |
Chemical Modification | None |
Linear/ Cyclic | Linear |
Nature | Protein Derived |
Source of Origin | kinase inhibitory region (KIR) of the intracellular checkpoint protein suppressor of cytokine signaling 1 (SOCS-1 |
Target | phospho-tyrosine containing regions of the tyrosine kinases JAK2 and TYK2 and the adaptor protein MAL |
Mechanism of Action | By blocking the inflammtory effects of IFN-γ, TNF-α or IL-17A. |
In vitro/In vivo | Both |
Cell Line | ARPE-19 cell |
Inhibition Concentartion | NA |
In vivo Model | B10. RIII mice |
Assay | immunohistochemistry |
Lethal Dose | NA |
Combination Therapy | NA |
Pubmed ID | 30048621 |
Year of Publication | 2018 |
3-D Structure | NA |