| Primary information |
|---|
| ID | 1550 |
| Peptide Name | R9-SOCS1-KIR |
| Sequence | RRRRRRRRRDTH-FRTFRSHSDYRRI |
| Length | 25 |
| Chirality | L |
| N-terminal Modification | None |
| C-terminal Modification | None |
| Chemical Modification | None |
| Linear/ Cyclic | Linear |
| Nature | Protein Derived |
| Source of Origin | kinase inhibitory region (KIR) of the intracellular checkpoint protein suppressor of cytokine signaling 1 (SOCS-1 |
| Target | phospho-tyrosine containing regions of the tyrosine kinases JAK2 and TYK2 and the adaptor protein MAL |
| Mechanism of Action | By blocking the inflammtory effects of IFN-γ, TNF-α or IL-17A. |
| In vitro/In vivo | Both |
| Cell Line | ARPE-19 cell |
| Inhibition Concentartion | NA |
| In vivo Model | B10. RIII mice |
| Assay | immunohistochemistry |
| Lethal Dose | NA |
| Combination Therapy | NA |
| Pubmed ID | 30048621 |
| Year of Publication | 2018 |
| 3-D Structure | NA |
