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The total number entries retrieved from this search are 594
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Note: Potential Biomarker with * indicates these signatures are candidate biomarkers extracted from experiments on mice, rat or cell lines and they are not validated on human patients'cohort.
Biomarker IDBiomarkerBiomoleculeSubjectRegulationBiomarker's typeExperimentLevel of significanceSourcePMID
2451IPO9RNAsHumanUpregulated in highly invasive HCC than less-invasive HCC (with fold change of 1.64 ) Prognosticless (L) invasive HCC v/s highly (H) invasive HCC; associated with survival of patients p < 0.01Tissue19945130
2452MTA3RNAsHumanUpregulated in highly invasive HCC than less-invasive HCC (with fold change of 1.61 ) Prognosticless (L) invasive HCC v/s highly (H) invasive HCC; associated with survival of patients p < 0.01Tissue19945130
2453CSRP2BPRNAsHumanUpregulated in highly invasive HCC than less-invasive HCC (with fold change of 1.57 ) Prognosticless (L) invasive HCC v/s highly (H) invasive HCC; associated with survival of patients p < 0.01Tissue19945130
2454XPO1RNAsHumanUpregulated in highly invasive HCC than less-invasive HCC (with fold change of 1.44 ) Prognosticless (L) invasive HCC v/s highly (H) invasive HCC; associated with survival of patients p < 0.01Tissue19945130
2455C14orf93RNAsHumanUpregulated in highly invasive HCC than less-invasive HCC (with fold change of 1.43 ) Prognosticless (L) invasive HCC v/s highly (H) invasive HCC; associated with survival of patients p < 0.01Tissue19945130
2456C5orf13RNAsHumanUpregulated in highly invasive HCC than less-invasive HCC (with fold change of 2.56 ) Prognosticless (L) invasive HCC v/s highly (H) invasive HCC; associated with survival of patients p < 0.01Tissue19945130
2457EHMT2RNAsHumanUpregulated in highly invasive HCC than less-invasive HCC (with fold change of 1.80 ) Prognosticless (L) invasive HCC v/s highly (H) invasive HCC; associated with survival of patients p < 0.01Tissue19945130
2458STX6RNAsHumanUpregulated in highly invasive HCC than less-invasive HCC (with fold change of 1.24 ) Prognosticless (L) invasive HCC v/s highly (H) invasive HCC; associated with survival of patients p < 0.01Tissue19945130
2459MCM8RNAsHumanUpregulated in highly invasive HCC than less-invasive HCC (with fold change of 2.34 ) Prognosticless (L) invasive HCC v/s highly (H) invasive HCC; associated with survival of patients p < 0.01Tissue19945130
2460MEF2BRNAsHumanUpregulated in highly invasive HCC than less-invasive HCC (with fold change of 1.49) Prognosticless (L) invasive HCC v/s highly (H) invasive HCC; associated with survival of patients p < 0.01Tissue19945130
2461FAM34A, NARS, HSPC152, GRP58, GBA, PVRL2, RPS17, LAMR1, GNB1, AHNAK, GRCC10, SPTAN1, CTSC, NSE1, COP1, NDRG1, HSPA5, SPARC, ATP5J2, KIAA0663, CD24, NUDT3, CANXRNAsHumanDownregulated in among all types HCC v/s non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue16391793
2462SMYD3, FABP1, Ceruloplasmin, A2M, IGFBP, PPAP2B, SHMT, PHLDA1, APOA1, SOCS2, ETS2, MT2A, CYP39A1, HAMP, CYP2C9, SLC22A1, PLG, GAMT, FGG, KRT8, IFITM1, C1R, FGB, FGA, GC (vitamin D binding protein), SERPINA3, WAC,RNAsHumanUpregulated in among all types HCC v/s non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue16391793
2463CLURNAsHumanUpregulated in metastatic HCC than primary HCC Diagnostic and PrognosticPrimary and metastatic HCC p < 0.001Cell line and Tissue16247463
2464EGR3, MFAP3, EST, MMP9, PDCD4, EST, FLJ37853, ARHE, MAD2L1, NMNAT2, FLJ22016, SND1, MIDORI, FLJ36229, MGST2, CTPS2, OASL, HK2, EEF2, Taxilin, NT5C, CLNS1A, UNC5B, TSC, TNFSF6, KIAA1691, S100A10, ATP6V1D, ASB4, AGR2, KIAA0205, JJAZ1, LOC285859, KIAA0157, PPA2, eIF3k, SGKL, BLMH, ERG-1, BRCA2, PPP2R2ARNAsHumanDifferentially expressed (14 Upregulated and 49 Downregulated) in treatment responder v/s non-responders Predictivetreatment responder v/s non-responders p < 0.01Tissue15447987
2465GPC3, CAP2, UBD, MT1F, PTDSS1, RDS, ID1, NNMT, AA127809, PRRG2, ACAA1, SLC22A1, BE779749, FACL2, PRLR, C8orf4, C6, CCNH, AK022114, CBFA2T3, EPAS1, API5, SULT2A1, PGM1, C9, NQO1, C1R, PMS1, DSCR1, PPP1R2, GOT1, ZNF6, AI831040, GCLC, MYOZ2, HMGCL, UBE4A, SERPING1, PLG, ADFP, RODH, MARCO, C9orf59, BG71RNAsHumanDifferentially expressed (GPC3, CAP2, UBD Upregulated and rest 41 are Downregulated) in tumor v/s non-tumor DiagnosticHCC v/s non-tumor p < 0.001Tissue15607117
2466MT1B, MT1E, MT1L, CP, ABCA1, CACNB3, PROS1, CPB2, SERPINC1, LACI, MDK, C6, C9, CD5L, GPR126, IL1RAP, DYRK3, PCDH17, TACSTD1, UAP1, C20orf3, CFL2, FLJ12666, KIAA0843, MRC1, NAT2, MYO1B, SIPL, SRD5A2, USP1,RNAsHumanDifferentially expressed (PCDH17, MDK, TACSTD1 Upregulated and rest 27 are Downregulated) in High-risk individuals with cirrhosis v/s patients with HCC PrognosticHigh-risk individuals with cirrhosis v/s patients with HCC p < 0.0003Tissue14768006
2467GRP94, GRP78, GRP75, HSC71, HSP90, HSP70, HSP60, Aconitase, EF-2, Nucleophosmin, VIM, NDK-A, Argininosuccinate synthase, CPSASE-I,ProteinHumanDifferentially expressed (Argininosuccinate synthase, Carbamoyl-phosphate synthase (CPSASE I) are Downregulated and rest 12 are Upregulated) in HCC tumor v/s non-tumorous DiagnosticHCC tumor v/s non-tumorous p < 0.05Tissue14654528
2468hnRNP K, HSP70RY, Lamin B1, 40S ribosomal protein SA, FTCD, SOD, Arginase, SMP-30, P5C dehydrogenase, Transitional endoplasmic reticulum ATPase, Ubiquitin carboxyl-terminal hydrolase 5, Thiosulfate sulfurtransferase (Rhodanese), Betaine-himocysteine S-methyltransferase, NCC27, FGB, RACK1, PDI, SARDHProteinHumanDifferentially expressed (hnRNP K, HSP70 RY, Lamin B1, 40S ribosomal protein SA, Transitional endoplasmic reticulum ATPase, Ubiquitin carboxyl-terminal hydrolase 5, Rhodanese, Betaine-himocysteine S-methyltransferase, NCC27, Fibrinogen β chain, RACK1 are Upregulated and rest 12 are Downregulated) DiagnosticHBV associated HCC tumor v/s non-tumorous p < 0.05Tissue14654528
2469GABA-AT, Cytosol aminopepsidase, AFB1-AR2, Acyl-CoA dehydrogenase, GDH,ProteinHumanDifferentially expressed (GABA-AT, AFB1-AR2) are Upregulated and rest 3 are Downregulated) in HCC tumor v/s non-tumorous DiagnosticHCV associated HCC tumor v/s non-tumorous p < 0.05Tissue14654528
2470HSP27, Enoyl-CoA hydratase, Tubulin β chain, Galactose kinase, Ubiquinol-cytochrome C reductase complex core protein I, Annexin V, P-PST, Ribosome binding protein, Fumarylacetoacetase, ALDH, Catalase,ProteinHumanDifferentially expressed (P-PST, Ribosome binding protein, Fumarylacetoacetase, Catalase and ALDH are Downregulated and rest 6 are Upregulated) in HCC tumor v/s non-tumorous DiagnosticBoth HBV- and HCV associated HCC tumor v/s non-tumorous p < 0.05Tissue14654528
2471Protein disulfide isomerase ER-60, PRBP, Tropomyosin 3, ATP synthase, Dihydropipoamide dehydrogenase, FABP, Cathepsin B1,ProteinHumanDifferentially expressed (FABP, Cathepsin B1 are Downregulated and rest 5 are Upregulated) in HCC tumor v/s non-tumorous Diagnosticboth (HBV and HCV) negative HCC tumor v/s non-tumorous p < 0.05Tissue14654528
2472AURKBProtein and RNAsHumanUpregulated in HCC tissues in association with aggressive recurrence v/s non-recurrence PrognosticAggressive recurrence HCC v/s non-recurrence HCC p < 0.001Tissue18311747
2473hnRNP C1/C2ProteinHumanUpregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2474Hcp70/Hsp90-organizing protein (HOP)ProteinHumanUpregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2475GRP-78ProteinHumanUpregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2476heat shock 70-kDa protein 1ProteinHumanUpregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2477heat shock 70-kDa protein 4ProteinHumanUpregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2478T-complex protein 1ProteinHumanUpregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2479MATProteinHumanDownregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2480GNMTProteinHumanDownregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2481BHMTProteinHumanDownregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2482COMTProteinHumanDownregulated in HCC tissues in HCC tumor than non-tumor DiagnosticHCC v/s non-tumor p < 0.01Tissue17627933
2483MYO1D, EST, PDGF-B, LOC113246, SPTAN1, MGC19556, IL6R, PRPSAP1, PDCD6IP, AHNAK, BCL2L11, GPAA1, c-fos, SLC11A2, LOC51235, PRPF8, CD36L1, KIAA1055, HNRPDL, NDRG1, NARS, PABPC4, RDBP, CALM2, PDCD6, C1R, ALB, MT1G, CED-6, AMACR, A2M, FGG, SUPV3L1, PHLDA1, NBP, HAMP, HCS, KIAA0635, ECHS1, SHMT1, NNMT, ARNAsHumanDifferentially expressed between HCC and non-tumor liver tissue DiagnosticHCC v/s non-tumor p < 0.01Tissue14642619
2484SOX6, ITIH4, HDGF, SKIP1, RBP4, LOC92033, UGT2B7, FABP1, GATM, UQCRC1, UK114, CP, PBEF, KAL1, CES2, GPX4, UGT1A4, RCL, PABPC1, EST, FGA, RARRES2, SLC22A, SRP14, FLJ14294, cyclin, CA2, CLDN1, FTL, FLJ10004, CYP3A5, ARHGEF12, TDO2, NDUFB2, TEGT, SPR, PCK2, MGC13114, EST, MTHFS, F2, FLJ22313, C9orf5, HRNAsHumanDifferentially expressed between HCC and normal tissues DiagnosticHCC v/s normal p < 0.01Tissue14642619
2485IGFBP3, c-fos, p21RNAsHumanDifferentially expressed between HCC and non-tumor liver tissue DiagnosticHCC v/s non-tumor p < 0.01Tissue14642619
2486p53, cyclin D1RNAsHumanDifferentially expressed between HCC and normal tissues DiagnosticHCC v/s normal p < 0.01Tissue14642619
2487Protein disulfide isomerase A3ProteinHumanUpregulated in HCC than non tumor (with mean ratio of 4.3 +/- 3.7) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271
2488Heat shock 27 kDa proteinProteinHumanDownregulated in HCC than non tumor (with mean ratio of nearly 8.4 +/- 5.8) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271
2489Glycerol-3-phosphate dehydrogenaseProteinHumanDownregulated in HCC than non tumor (with mean ratio of nearly 9.9 +/- 9.6) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271
2490Senescence marker protein-30ProteinHumanDownregulated in HCC than non tumor (with mean ratio of nearly 7.9 +/- 11.1) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271
2491Acyl-CoA dehydrogenaseProteinHumanDownregulated in HCC than non tumor (with mean ratio of nearly 4.7 +/- 2.5) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271
2492KetohexokinaseProteinHumanDownregulated in HCC than non tumor (with mean ratio of nearly 4.7 +/- 3.7) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271
2493GRB2ProteinHumanDownregulated in HCC than non tumor (with mean ratio of nearly 6.7 +/- 5.4) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271
2494Aldehyde dehydrogenaseProteinHumanDownregulated in HCC than non tumor (with mean ratio of nearly 3.7 +/- 2.8) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271
2495Cathepsin DProteinHumanDownregulated in HCC than non tumor (with mean ratio of nearly 3.5 +/- 3.3) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271
2496Guanidinoacetate N-methyltransferaseProteinHumanDownregulated in HCC than non tumor (with mean ratio of nearly 5.3 +/- 8.6) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271
2497Catechol O-methyltransferaseProteinHumanDownregulated in HCC than non tumor (with mean ratio of nearly 3.2 +/- 3.8) DiagnosticHCC v/s non-tumor p < 0.05Tissue12481271
2498TGM2ProteinHumanUpregulated in HCC than non tumor DiagnosticHCC v/s normal p < 0.05Cell line, Tissue, Serum18646787
2499SEMA3F, DDX17, TNFAIP, PDGFRA, VIM, LAPTM5, CCND2, HLADRA, MEF2C, Staf50, SGK, REL,RNAsHumanDiffrenetially Expressed between recurrent and non-recurrent HCC PrognosticEarly intrahepatic recurrence and non-recurrence HCC p < 0.05Tissue12648972
2500RYBP, ATP1B3, TMC, ZNF567, GPR108, CD19, SPINK1, CDC2L6, RSRC1, METAP, GPC3, SNHG11, RY1, CRELD2, GLUL, SERPINB1, TRMT6, UNC13D, E4F1--E4F, SLC22A2, CNIH4, TK1, MAFB, PPP1CB, DNTTIP2, ARID4B, SMARCC2, PRO1386, TRIOBP, VARS, ITGA5, TERF1, PURA, TUBA1B, SNRPE, RRAGD, VWF, GLRX3, ILF2,RNAsHumanUpregulated in HCV related HCC than normal control (With 3-fold change) DiagnosticHCV related HCC v/s normal control p < 0.01Tissue19821982

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