| Detailed information |
|---|
| CancerLivER ID | 2472 |
| Biomarker | AURKB |
| Biomarker Name/Symbol (given in Publication) | Aurora kinase B |
| Biomolecule | Protein and RNAs |
| Subject | Human |
| Degree of Validity | Prognostic marker for HCC recurrence (Aurora kinase B protein expression was significantly associated with aggressive recurrence (P < 0·001) and prognosis (P < 0·001)) and validated on independent dataset |
| Experimental Condition | Aggressive recurrence HCC v/s non-recurrence HCC |
| Cancer type | Hepatocellular carcinoma |
| Regulation | Upregulated in HCC tissues in association with aggressive recurrence v/s non-recurrence |
| Level of significance | p < 0.001 |
| Source | Tissue |
| PMID | 18311747 |
| Type of Biomarker | Prognostic |
| Pathway | transferase activity, transferring phosphorus-containing groups and protein tyrosine kinase activity. |
| Cohort | Primary HCC tissues from 107 patients (22 HCC samples in the microarray group and an additional 67 HCC samples for validation [22 cases with aggressive recurrence and 45 cases with no-recurrence]) |
| Sensitivity | NA |
| Specificity | NA |
| Accuracy | NA |
| AUC | NA |
| Disease | Aggressive recurrence HCC v/s non-recurrence HCC |
| Year of Publication | 2008 |
| Clinical trial | YES |
| NCT No# (Clinical trial) | NCT03245190 |