| Detailed information |
|---|
| CancerLivER ID | 2468 |
| Biomarker | hnRNP K, HSP70RY, Lamin B1, 40S ribosomal protein SA, FTCD, SOD, Arginase, SMP-30, P5C dehydrogenase, Transitional endoplasmic reticulum ATPase, Ubiquitin carboxyl-terminal hydrolase 5, Thiosulfate sulfurtransferase (Rhodanese), Betaine-himocysteine S-methyltransferase, NCC27, FGB, RACK1, PDI, SARDH |
| Biomarker Name/Symbol (given in Publication) | 23-proteins signature (Heterogeneous nuclear ribonucleoprotein K (hnRNP K), Heat shock 70 kDa protein 4 (HSP70 RY), Lamin B1, 40S ribosomal protein SA, Formininotransferase-cyclodeaminase (FTCD), SOD [Cu-Zn], Arginase, Senescence marker protein-30 (SMP-30), P5C dehydrogenase, Transitional endoplasmic reticulum ATPase, Ubiquitin carboxyl-terminal hydrolase 5, Thiosulfate sulfurtransferase (Rhodanese), Betaine-himocysteine S-methyltransferase, Chloride intracellular channel protein I (NCC27), Fibrinogen β chain, Receptor of activated protein kinase C 1 (RACK1), Protein disulfide isomerase (PDI), Sarcosine dehydrogenase (SARDH), Cytochrome B5, Phosphatidylethanolamine-binding protein (PEBP), Fructose-bisphosphate aldolase B, alpha- enolase, Serotransferrin precursor) |
| Biomolecule | Protein |
| Subject | Human |
| Degree of Validity | HBV- associated HCC marker; but not validated on independent dataset |
| Experimental Condition | HBV associated HCC tumor v/s non-tumorous |
| Cancer type | Hepatocellular carcinoma |
| Regulation | Differentially expressed (hnRNP K, HSP70 RY, Lamin B1, 40S ribosomal protein SA, Transitional endoplasmic reticulum ATPase, Ubiquitin carboxyl-terminal hydrolase 5, Rhodanese, Betaine-himocysteine S-methyltransferase, NCC27, Fibrinogen β chain, RACK1 are Upregulated and rest 12 are Downregulated) |
| Level of significance | p < 0.05 |
| Source | Tissue |
| PMID | 14654528 |
| Type of Biomarker | Diagnostic |
| Pathway | NA |
| Cohort | Paired tumorous and surrounding nontumorous tissues obtained from 21 HCC patients. They were divided into three HCC types by viral markers: 7 hepatitis B surface antigen-positive (B-type HCC), 7 anti-HCV-positive (C-type HCC), and 7 hepatitis B surface antigen-negative and anti-HCV-negative. |
| Sensitivity | NA |
| Specificity | NA |
| Accuracy | NA |
| AUC | NA |
| Disease | HBV- associated HCC |
| Year of Publication | 2003 |
| Clinical trial | NO |
| Clinical trial (NCT Number) | NA |