Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_0008Candida albicans

Click for more detail

Candida albicans(fungi)NANAWhole cellNaturalCandida albicans binds with human macrophage mannose receptor via carbohydrate recognition-like domains.Mannose receptorMannose receptor (MR)HumanMacrophagesCRDsP22897.fastaP228971456It leads to the receptor-mediated endorytosis of mannose-rich glycoconjugate as well as phagocytosis as well as pinocytisisof yeasts.Phagocytosis assay22587071990Pubchem Assay
PRRID_0008Candida albicans

Click for more detail

Candida albicans(fungi)NANAWhole cellNaturalCandida albicans binds with human macrophage mannose receptor via carbohydrate recognition-like domains.Mannose receptorMannose receptor (MR)HumanMacrophagesCRDsP22897.fastaP228971456It leads to the receptor-mediated endorytosis of mannose-rich glycoconjugate as well as phagocytosis as well as pinocytisisof yeasts.Phagocytosis assay22587071990Pubchem Assay
PRRID_0011D-mannose

Click for more detail

BacteriaC(C1C(C(C(C(O1)O)O)O)O)ONACarbohydrateNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0011D-mannose

Click for more detail

BacteriaC(C1C(C(C(C(O1)O)O)O)O)ONACarbohydrateNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0013L-fucose

Click for more detail

BacteriaCC(C(C(C(C=O)O)O)O)ONACarbohydrateNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0013L-fucose

Click for more detail

BacteriaCC(C(C(C(C=O)O)O)O)ONACarbohydrateNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0014N-acetylmannosamine

Click for more detail

BacteriaCC(=O)NC1C(C(C(OC1O)CO)O)ONACarbohydrateNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0014N-acetylmannosamine

Click for more detail

BacteriaCC(=O)NC1C(C(C(OC1O)CO)O)ONACarbohydrateNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0017TPA (tissue plasminogen activator)

Click for more detail

Endogenous (others)PERLQRVVTPVLARTDSEPSGLRGTHKPHRWGCRCGAHRAGARLVGTGMGPGESALGWAARMPPALFPPSHPFHFQRPRDIFKGKGKDREKCQAGLGSGPVGSSGRRGGLYHDGLELGLEVSLPGCWESPGGQEGCSRLREGQVQSPEWGRRWAAVWVVQPDWTEC166ProteinNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0017TPA (tissue plasminogen activator)

Click for more detail

Endogenous (others)PERLQRVVTPVLARTDSEPSGLRGTHKPHRWGCRCGAHRAGARLVGTGMGPGESALGWAARMPPALFPPSHPFHFQRPRDIFKGKGKDREKCQAGLGSGPVGSSGRRGGLYHDGLELGLEVSLPGCWESPGGQEGCSRLREGQVQSPEWGRRWAAVWVVQPDWTEC166ProteinNaturalelicit innate immune responseMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456Induces pro-inflammatory cytokine responseNA19068881991Pubchem Assay
PRRID_0025Mannan

Click for more detail

FungiCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalImmunostimulantMannose receptorMannose receptor (MR)NANANANANANANAELISA84169461993NA
PRRID_0025Mannan

Click for more detail

FungiCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAPolysaccharidesNaturalImmunostimulantMannose receptorMannose receptor (MR)NANANANANANANAELISA84169461993NA
PRRID_0044surfactant protein-A

Click for more detail

Host (Endogenous) (others)MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF248ProteinNaturalCarbohydrate moieties of SP-A enhanced adherence of Mycobacterium tuberculosis.Mannose receptorMannose receptor (MR)HumanMonocytes-derived macrophagesNAP22897.fastaP228971456Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis.NA75945491995Pubchem Assay
PRRID_0044surfactant protein-A

Click for more detail

Host (Endogenous) (others)MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF248ProteinNaturalCarbohydrate moieties of SP-A enhanced adherence of Mycobacterium tuberculosis.Mannose receptorMannose receptor (MR)HumanMonocytes-derived macrophagesNAP22897.fastaP228971456Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis.NA75945491995Pubchem Assay
PRRID_0045surfactant protein-A

Click for more detail

Host (Endogenous) (others)MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF248ProteinNaturalCarbohydrate moieties of SP-A enhanced adherence of Mycobacterium tuberculosis.Mannose receptorMannose receptor (MR)HumanAlveolar macrophagesNAP22897.fastaP228971456Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis.NA75945491995Pubchem Assay
PRRID_0045surfactant protein-A

Click for more detail

Host (Endogenous) (others)MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF248ProteinNaturalCarbohydrate moieties of SP-A enhanced adherence of Mycobacterium tuberculosis.Mannose receptorMannose receptor (MR)HumanAlveolar macrophagesNAP22897.fastaP228971456Pulmonary surfactant protein A mediates enhanced phagocytosis of Mycobacterium tuberculosis.NA75945491995Pubchem Assay
PRRID_0050lipo-arabinomannan

Click for more detail

mycobacteria (Mycobacterium tuberculosis; Erdman strain) (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalImmunostimulantMannose receptorMannose receptor (MR)HumanMacrophagesNAP22897.fastaP228971456NAChromatographic analyses 89068351996Pubchem Assay
PRRID_0050lipo-arabinomannan

Click for more detail

mycobacteria (Mycobacterium tuberculosis; Erdman strain) (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalImmunostimulantMannose receptorMannose receptor (MR)HumanMacrophagesNAP22897.fastaP228971456NAChromatographic analyses 89068351996Pubchem Assay
PRRID_0079Chondroitin Sulfates A

Click for more detail

Host (Endogenous) (others)CC(=O)NC1C(C(C(OC1O)CO)OS(=O)(=O)O)OC2C(C(C(C(O2)C(=O)O)O)O)ONACarbohydrateNaturalChondroitin Sulfates A binds to mannose receptor via a membrane-distal cysteine-rich domain (Cys-MR).Cys-MRMannose receptor (MR)HumanSpleenocytescarbohydrate-recognition domain (CRD)NANANAThe Cysteine-rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates A and B and Sulfated Oligosaccharides of Blood Group.NA107482302000NA
PRRID_0079Chondroitin Sulfates A

Click for more detail

Host (Endogenous) (others)CC(=O)NC1C(C(C(OC1O)CO)OS(=O)(=O)O)OC2C(C(C(C(O2)C(=O)O)O)O)ONACarbohydrateNaturalChondroitin Sulfates A binds to mannose receptor via a membrane-distal cysteine-rich domain (Cys-MR).Cys-MRMannose receptor (MR)HumanSpleenocytescarbohydrate-recognition domain (CRD)NANANAThe Cysteine-rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates A and B and Sulfated Oligosaccharides of Blood Group.NA107482302000NA
PRRID_0080Chondroitin Sulfates B

Click for more detail

Host (Endogenous) (others)NANACarbohydrateNaturalChondroitin Sulfates A binds to mannose receptor via a membrane-distal cysteine-rich domain (Cys-MR).Cys-MRMannose receptor (MR)HumanSpleenocytescarbohydrate-recognition domain (CRD)NANANAThe Cysteine-rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates A and B and Sulfated Oligosaccharides of Blood Group.NA107482302000NA
PRRID_0080Chondroitin Sulfates B

Click for more detail

Host (Endogenous) (others)NANACarbohydrateNaturalChondroitin Sulfates A binds to mannose receptor via a membrane-distal cysteine-rich domain (Cys-MR).Cys-MRMannose receptor (MR)HumanSpleenocytescarbohydrate-recognition domain (CRD)NANANAThe Cysteine-rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates A and B and Sulfated Oligosaccharides of Blood Group.NA107482302000NA
PRRID_0095Sulfated blood group chains

Click for more detail

Host (Endogenous) (others)NANACarbohydrateNaturalChondroitin Sulfates A binds to mannose receptor via a membrane-distal cysteine-rich domain (Cys-MR).Cys-MRMannose receptor (MR)HumanSpleenocytescarbohydrate-recognition domain (CRD)NANANAThe Cysteine-rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates A and B and Sulfated Oligosaccharides of Blood Group.NA107482302000NA
PRRID_0095Sulfated blood group chains

Click for more detail

Host (Endogenous) (others)NANACarbohydrateNaturalChondroitin Sulfates A binds to mannose receptor via a membrane-distal cysteine-rich domain (Cys-MR).Cys-MRMannose receptor (MR)HumanSpleenocytescarbohydrate-recognition domain (CRD)NANANAThe Cysteine-rich Domain of the Macrophage Mannose Receptor Is a Multispecific Lectin That Recognizes Chondroitin Sulfates A and B and Sulfated Oligosaccharides of Blood Group.NA107482302000NA
PRRID_0114alpha-methylmannoside

Click for more detail

BacteriaCOC1C(C(C(C(O1)CO)O)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0114alpha-methylmannoside

Click for more detail

BacteriaCOC1C(C(C(C(O1)CO)O)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0117Fucose

Click for more detail

BacteriaCC(C(C(C(C=O)O)O)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0117Fucose

Click for more detail

BacteriaCC(C(C(C(C=O)O)O)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0118glucose

Click for more detail

BacteriaC(C1C(C(C(C(O1)O)O)O)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0118glucose

Click for more detail

BacteriaC(C1C(C(C(C(O1)O)O)O)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0138Mannose

Click for more detail

FungiC(C1C(C(C(C(O1)O)O)O)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0138Mannose

Click for more detail

FungiC(C1C(C(C(C(O1)O)O)O)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0140N-acetylmannosamine

Click for more detail

BacteriaCC(=O)NC1C(C(C(OC1O)CO)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0140N-acetylmannosamine

Click for more detail

BacteriaCC(=O)NC1C(C(C(OC1O)CO)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0141N-acetylmannosamine

Click for more detail

BacteriaCC(=O)NC1C(C(C(OC1O)CO)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0141N-acetylmannosamine

Click for more detail

BacteriaCC(=O)NC1C(C(C(OC1O)CO)O)ONACarbohydrateNaturalImmunostimulantEndo180Mannose receptor (MR)HumanNAlectin-like domainsQ9UBG0.fastaQ9UBG01479NASugar-Binding assay123994582002Pubchem Assay
PRRID_0164Collagen

Click for more detail

Host (Endogenous) (others)MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGECCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPM1464ProteinNaturalelicit innate immune responseEndo180 (Endocytic receptor 180)Mannose receptor (MR)HumanEndosomesN-terminal cysteine-rich domain, a single fibronectin type II domain and eight C-type lectin- like domainsQ9UBG0.fastaQ9UBG01479Endo180 Functions in Cells as a Collagen Binding and Internalization ReceptorELISA129725492003Pubchem Assay
PRRID_0164Collagen

Click for more detail

Host (Endogenous) (others)MFSFVDLRLLLLLAATALLTHGQEEGQVEGQDEDIPPITCVQNGLRYHDRDVWKPEPCRICVCDNGKVLCDDVICDETKNCPGAEVPEGECCPVCPDGSESPTDQETTGVEGPKGDTGPRGPRGPAGPPGRDGIPGQPGLPGPPGPPGPPGPPGLGGNFAPQLSYGYDEKSTGGISVPGPMGPSGPRGLPGPPGAPGPQGFQGPPGEPGEPGASGPMGPRGPPGPPGKNGDDGEAGKPGRPGERGPPGPQGARGLPGTAGLPGMKGHRGFSGLDGAKGDAGPAGPKGEPGSPGENGAPGQMGPRGLPGERGRPGAPGPAGARGNDGATGAAGPPGPTGPAGPPGFPGAVGAKGEAGPQGPRGSEGPQGVRGEPGPPGPAGAAGPAGNPGADGQPGAKGANGAPGIAGAPGFPGARGPSGPQGPGGPPGPKGNSGEPGAPGSKGDTGAKGEPGPVGVQGPPGPAGEEGKRGARGEPGPTGLPGPPGERGGPGSRGFPGADGVAGPKGPAGERGSPGPAGPKGSPGEAGRPGEAGLPGAKGLTGSPGSPGPDGKTGPPGPAGQDGRPGPPGPPGARGQAGVMGFPGPKGAAGEPGKAGERGVPGPPGAVGPAGKDGEAGAQGPPGPAGPAGERGEQGPAGSPGFQGLPGPAGPPGEAGKPGEQGVPGDLGAPGPSGARGERGFPGERGVQGPPGPAGPRGANGAPGNDGAKGDAGAPGAPGSQGAPGLQGMPGERGAAGLPGPKGDRGDAGPKGADGSPGKDGVRGLTGPIGPPGPAGAPGDKGESGPSGPAGPTGARGAPGDRGEPGPPGPAGFAGPPGADGQPGAKGEPGDAGAKGDAGPPGPAGPAGPPGPIGNVGAPGAKGARGSAGPPGATGFPGAAGRVGPPGPSGNAGPPGPPGPAGKEGGKGPRGETGPAGRPGEVGPPGPPGPAGEKGSPGADGPAGAPGTPGPQGIAGQRGVVGLPGQRGERGFPGLPGPSGEPGKQGPSGASGERGPPGPM1464ProteinNaturalelicit innate immune responseEndo180 (Endocytic receptor 180)Mannose receptor (MR)HumanEndosomesN-terminal cysteine-rich domain, a single fibronectin type II domain and eight C-type lectin- like domainsQ9UBG0.fastaQ9UBG01479Endo180 Functions in Cells as a Collagen Binding and Internalization ReceptorELISA129725492003Pubchem Assay
PRRID_0207Opacity protein

Click for more detail

Neisseria meningitidis (Bacteria)MNPAPKNLLFSSLLFSSLLFSSLLFSSAAQAASEDSSRSPYYVQADLAYAAERITHDYPKATGANNTSTVSDYFRNIRAHSIHPRVSVGYDFGDWRIAADYASYRKWNNNKYSVNTKEVSRNNSNGNDTWQELKTENQENGSFHAVSSLGLSAIYDFKLNDKFDKFKPYIGARVAYGHVKHQVHSVRKETTTVFSKPSGSATKPGQIPSLVTKPAYHESHSISSLGLGVIAGVGFDITPKLTLDTGYRYHNWGRLENTRFKTHEVSLGVRYRF273ProteinNaturalelicit innate immune responseMannose-binding lectinsMannose receptor (MR)HumanNANAB1PN75.fastaB1PN7538MBL binding to N. meningitidis and increases complement activation and killing of organisms.ELISA150041832004Pubchem Assay
PRRID_0207Opacity protein

Click for more detail

Neisseria meningitidis (Bacteria)MNPAPKNLLFSSLLFSSLLFSSLLFSSAAQAASEDSSRSPYYVQADLAYAAERITHDYPKATGANNTSTVSDYFRNIRAHSIHPRVSVGYDFGDWRIAADYASYRKWNNNKYSVNTKEVSRNNSNGNDTWQELKTENQENGSFHAVSSLGLSAIYDFKLNDKFDKFKPYIGARVAYGHVKHQVHSVRKETTTVFSKPSGSATKPGQIPSLVTKPAYHESHSISSLGLGVIAGVGFDITPKLTLDTGYRYHNWGRLENTRFKTHEVSLGVRYRF273ProteinNaturalelicit innate immune responseMannose-binding lectinsMannose receptor (MR)HumanNANAB1PN75.fastaB1PN7538MBL binding to N. meningitidis and increases complement activation and killing of organisms.ELISA150041832004Pubchem Assay
PRRID_0208Porins

Click for more detail

Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396ProteinNaturalelicit innate immune responseMannose-binding lectinsMannose receptor (MR)HumanNANAB1PN75.fastaB1PN7538MBL binding to N. meningitidis and increases complement activation and killing of organisms.ELISA150041832004Pubchem Assay
PRRID_0208Porins

Click for more detail

Neisseria meningitidis (Bacteria)MRKKLTALVLSALPLAAVADVSLYGEIKAGVEGRNYQLQLTEAQAANGGASGQVKVTKVTKAKSRIRTKISDFGSFIGFKGSEDLGDGLKAVWQLEQDVSVAGGGATQWGNRESFIGLAGEFGTLRAGRVANQFDDASQAIDPWDSNNDVASQLGIFKRHDDMPVSVRYDSPEFSGFSGSVQFVPIQNSKSAYTPAYYTKNTNNNLTLVPAVVGKPGSDVYYAGLNYKNGGFAGNYAFKYARHANVGRNAFELFLIGSARSDQAKGTDPLKNHQVHRLTGGYEEGGLNLALAAQLDLSENGDKAKTKNSTTEIAATASYRFGNAVPRISYAHGFDFIERGKKGENTSYDQIIAGVDYDFSKRTSAIVSGAWLKRNTGIGNYTQINAASVGLRHKF396ProteinNaturalelicit innate immune responseMannose-binding lectinsMannose receptor (MR)HumanNANAB1PN75.fastaB1PN7538MBL binding to N. meningitidis and increases complement activation and killing of organisms.ELISA150041832004Pubchem Assay
PRRID_0378Pseudomonas aeruginosa

Click for more detail

Pseudomonas aeruginosa (Bacteria)NANAWhole organismNaturalP. aeruginosa activates NF-kappaB and MAPK, leads to the producion of proinflammatory cytokines.Mannose receptorMannose receptor (MR)HumanMonocytesNAP22897.fastaP228971456It has the role in the inflammation.ELISA191979422009Pubchem Assay
PRRID_0378Pseudomonas aeruginosa

Click for more detail

Pseudomonas aeruginosa (Bacteria)NANAWhole organismNaturalP. aeruginosa activates NF-kappaB and MAPK, leads to the producion of proinflammatory cytokines.Mannose receptorMannose receptor (MR)HumanMonocytesNAP22897.fastaP228971456It has the role in the inflammation.ELISA191979422009Pubchem Assay
PRRID_0606lipo-arabinomannan

Click for more detail

M. tuberculosis (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalBinding of ligand leads to the inhibition of phagolysosome maturationMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456It ensure its survival of M. toberculosis in the hostNA204887842010Pubchem Assay
PRRID_0606lipo-arabinomannan

Click for more detail

M. tuberculosis (Bacteria)CCC(CO)NCCNC(CC)CONAGlycolipidNaturalBinding of ligand leads to the inhibition of phagolysosome maturationMannose receptorMannose receptor (MR)HumanNANAP22897.fastaP228971456It ensure its survival of M. toberculosis in the hostNA204887842010Pubchem Assay
PRRID_0676mannose, fucose and N-acetylglucosamine residues

Click for more detail

Endogenous (others)C(C1C(C(C(C(O1)O)O)O)O)O, CC(C(C(C(C=O)O)O)O)O, CC(=O)NC1C(C(C(OC1O)CO)O)ONADamage-associated molecular patterns (DAMPs)NaturalThese ligands binds to MR in calcium-dependent fashion, leads to the secretion of proinflammatory molecules, resulted in inflammationMannose receptorMannose receptor (MR)Mice (Murine)macrophages, certain dendritic cells, endothelial cell and mesangial cellsNAQ61830.fastaQ618301456It helps in clearing endogenous ligands released in the inflammatory response including lysosomal hydrolases, tissue plasminogen activator and myeloperoxidase and also has tissue protection during inflammationNA206509062010Pubchem Assay
PRRID_0676mannose, fucose and N-acetylglucosamine residues

Click for more detail

Endogenous (others)C(C1C(C(C(C(O1)O)O)O)O)O, CC(C(C(C(C=O)O)O)O)O, CC(=O)NC1C(C(C(OC1O)CO)O)ONADamage-associated molecular patterns (DAMPs)NaturalThese ligands binds to MR in calcium-dependent fashion, leads to the secretion of proinflammatory molecules, resulted in inflammationMannose receptorMannose receptor (MR)Mice (Murine)macrophages, certain dendritic cells, endothelial cell and mesangial cellsNAQ61830.fastaQ618301456It helps in clearing endogenous ligands released in the inflammatory response including lysosomal hydrolases, tissue plasminogen activator and myeloperoxidase and also has tissue protection during inflammationNA206509062010Pubchem Assay
PRRID_1103Lipoteichoic Acid (LTA)

Click for more detail

Streptococcus pyogenes (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalPPL is a glycoprotein with a lipoteichoic acid binding specificity and elicits the downstream cascade.Philyra pisum lectin (PPL)Mannose receptor (MR)Philyra pisumNANANANANAIt has antiproliferative effects on human cancer cellsHemagglutination inhibition assay243815052013NA
PRRID_1103Lipoteichoic Acid (LTA)

Click for more detail

Streptococcus pyogenes (Bacteria)C(C1C(C(C(C(O1)OCC(CO)O)OC2C(C(C(C(O2)COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(COP(=O)(O)OCC(CO)O)O)O)O)O)O)O)O)O)ONAAmphiphileNaturalPPL is a glycoprotein with a lipoteichoic acid binding specificity and elicits the downstream cascade.Philyra pisum lectin (PPL)Mannose receptor (MR)Philyra pisumNANANANANAIt has antiproliferative effects on human cancer cellsHemagglutination inhibition assay243815052013NA
PRRID_1106Mannan

Click for more detail

S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)O)CO)CO)CO)O)O)O)ONAPolysaccharidesNaturalPPL is a glycoprotein with a mannan-binding specificity and elicits the downstream cascade.Philyra pisum lectin (PPL)Mannose receptor (MR)Philyra pisumNANANANANAIt has antiproliferative effects on human cancer cellsHemagglutination inhibition assay243815052013NA
PRRID_1106Mannan

Click for more detail

S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)O)CO)CO)CO)O)O)O)ONAPolysaccharidesNaturalPPL is a glycoprotein with a mannan-binding specificity and elicits the downstream cascade.Philyra pisum lectin (PPL)Mannose receptor (MR)Philyra pisumNANANANANAIt has antiproliferative effects on human cancer cellsHemagglutination inhibition assay243815052013NA
PRRID_1481Maltose-binding protein (MBP)

Click for more detail

E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396Pattern-associated molecular patterns (PAMPs)Naturalresponsible for the uptake and efficient catabolism of maltodextrinsMannose Receptor (CD206)Mannose receptor (MR)Miceperitoneal macrophagescell surfaceQ61830.fastaQ618301456Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammationELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR248256032014Pubchem_assay
PRRID_1481Maltose-binding protein (MBP)

Click for more detail

E. coli(Bacteria)MKIKTGARILALSALTTMMFSASALAKIEEGKLVIWINGDKGYNGLAEVGKKFEKDTGIKVTVEHPDKLEEKFPQVAATGDGPDIIFWAHDRFGGYAQSGLLAEITPDKAFQDKLYPFTWDAVRYNGKLIAYPIAVEALSLIYNKDLLPNPPKTWEEIPALDKELKAKGKSALMFNLQEPYFTWPLIAADGGYAFKYENGKYDIKDVGVDNAGAKAGLTFLVDLIKNKHMNADTDYSIAEAAFNKGETAMTINGPWAWSNIDTSKVNYGVTVLPTFKGQPSKPFVGVLSAGINAASPNKELAKEFLENYLLTDEGLEAVNKDKPLGAVALKSYEEELAKDPRIAATMENAQKGEIMPNIPQMSAFWYAVRTAVINAASGRQTVDEALKDAQTRITK396Pattern-associated molecular patterns (PAMPs)Naturalresponsible for the uptake and efficient catabolism of maltodextrinsMannose Receptor (CD206)Mannose receptor (MR)Miceperitoneal macrophagescell surfaceQ61830.fastaQ618301456Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammationELISA, Phagocytosis assay, Cytokine secretion assay, real-time PCR248256032014Pubchem_assay
PRRID_1482Mannan

Click for more detail

Fungi(Yeast)N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=ONAPolysaccharidesNaturalcell wall polysaccharide found in yeasts.Mannose receptorMannose receptor (MR)European and African ChildrenDC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin)NAA5D8T8.fastaA5D8T8446Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammationELISA247435422014Pubchem_assay
PRRID_1482Mannan

Click for more detail

Fungi(Yeast)N[C@@H](CCC[C@@H](NC(=O)CC[C@@H](N)C(O)=O)C(O)=O)C(O)=ONAPolysaccharidesNaturalcell wall polysaccharide found in yeasts.Mannose receptorMannose receptor (MR)European and African ChildrenDC-SIGN (dendritic cell-specific intercellular adhesion molecule-3-grabbing non-integrin)NAA5D8T8.fastaA5D8T8446Phagocytosis of pathogens, Antigen presentation, Intracellular signalling, Resolution of inflammationELISA247435422014Pubchem_assay
PRRID_1923App, MspA

Click for more detail

NANANANANaturalIn vivo virulenceMannose receptor/CD206 (terminal mannose, GlcNAc, fucose)Mannose receptor (MR)NACell surfaceNANANANANANA283342032017NA
PRRID_1923App, MspA

Click for more detail

NANANANANaturalIn vivo virulenceMannose receptor/CD206 (terminal mannose, GlcNAc, fucose)Mannose receptor (MR)NACell surfaceNANANANANANA283342032017NA
PRRID_2016endogenous glycoproteins

Click for more detail

NANANADamage-associated molecular patterns (DAMPs)Naturalelicit innate immune responseMannose Receptor 1Mannose receptor (MR)NANANANANANANANA288015212017NA
PRRID_2016endogenous glycoproteins

Click for more detail

NANANADamage-associated molecular patterns (DAMPs)Naturalelicit innate immune responseMannose Receptor 1Mannose receptor (MR)NANANANANANANANA288015212017NA
PRRID_2423NA

Click for more detail

pathogenic viruses, bacteria, and fungiNANANANaturalNAMRC1Mannose receptor (MR)HumanNANAP22897.fastaP228971456NANA290662552017Pubchem_assay
PRRID_2423NA

Click for more detail

pathogenic viruses, bacteria, and fungiNANANANaturalNAMRC1Mannose receptor (MR)HumanNANAP22897.fastaP228971456NANA290662552017Pubchem_assay
PRRID_2588repeated mannose units

Click for more detail

NAC(C1C(C(C(C(O1)O)O)O)O)O and CC(C(C(C(C=O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseMannose Receptor 1Mannose receptor (MR)NANANANANANANANA288015212017NA
PRRID_2588repeated mannose units

Click for more detail

NAC(C1C(C(C(C(O1)O)O)O)O)O and CC(C(C(C(C=O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)Naturalelicit innate immune responseMannose Receptor 1Mannose receptor (MR)NANANANANANANANA288015212017NA