Browse result page of PRRDB 2.0

PRRID	Name of Ligand	Source of ligand	Sequence of Ligand	Length of Ligand	Type of Ligand	Occurence	Role of Ligand	Name of Receptor	Type of Reeptor	Source of the Receptor	Localization	Domain	Sequence of Receptor	Swiss prot ID	Length of receptor	Function of Receptor	Assay used	PMID	Year of publication	Pubchem assay
PRRID_1643	surfactant protein-A Click for more detail	Host (Endogenous) (others)	MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF	248	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1643	surfactant protein-A Click for more detail	Host (Endogenous) (others)	MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF	248	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	Q9QUK6.fasta	Q9QUK6	835	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1644	surfactant protein-A Click for more detail	Host (Endogenous) (others)	MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF	248	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1644	surfactant protein-A Click for more detail	Host (Endogenous) (others)	MWLCPLALNLILMAASGAVCEVKDVCVGSPGIPGTPGSHGLPGRDGRDGLKGDPGPPGPMGPPGEMPCPPGNDGLPGAPGIPGECGEKGEPGERGPPGLPAHLDEELQATLHDFRHQILQTRGALSLQGSIMTVGEKVFSSNGQSITFDAIQEACARAGGRIAVPRNPEENEAIASFVKKYNTYAYVGLTEGPSPGDFRYSDGTPVNYTNWYRGEPAGRGKEQCVEMYTDGQWNDRNCLYSRLTICEF	248	Protein	Natural	triggers immune responses	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	monocyte/macrophages, Myeloid DCs, neutrophils, Mast cells, B-lymphocyte	signaling occurs through an adapter protein Toll/IL-1 receptor domain-containing adaptor inducing IFN-b (TRIF)	O00206.fasta	O00206	839	plays a fundamental role in pathogen recognition and activation of innate immunity	NA	24754320	2014	Pubchem_assay
PRRID_1646	Tandem CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	cluster of differentiation 147 (CD147)	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1646	Tandem CARDs Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	cluster of differentiation 147 (CD147)	Pattern recognition receptor (PRR)	NA	NA	NA	NA	NA	NA	NA	NA	25520185	2014	NA
PRRID_1649	TgPRF (T. gondii profilin-like protein) Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	potently activate the innate immune system through its specific recognition by TLR11, which plays an important role in T. gondii infection in mice	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Swiss albino mice brain	microglia/macrophages, astrocytes, and neurons	NA	Q6R5P0.fasta	Q6R5P0	926	TLR11 activation is unique in its ability to initiate a parasite-specific innate immune response. TLR11 is unusual in its recognition of T. gondii, because it senses the pathogen by recognizing a profilin released by the microbe rather than by directly interacting with the live parasite	Double-labeling immunohistochemistry, Real-time quantitative polymerase chain reaction (PCR)	24704432	2014	Pubchem_assay
PRRID_1649	TgPRF (T. gondii profilin-like protein) Click for more detail	T. gondii (others)	MSDWDPVVKEWLVDTGYCCAGGIANVSAEDGVVFAAAADDDDGWSKLYKDDHEEDTIGEDGNACGKVSINEASTIKAAVDDGSAPNGVWIGGQKYKVVRPEKGFEYNDCTFDITMCARSKGGAHLIKTPNGSIVIALYDEEKEQDKGNSRTSALAFAEYLHQSGY	165	Protein	Natural	potently activate the innate immune system through its specific recognition by TLR11, which plays an important role in T. gondii infection in mice	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Swiss albino mice brain	microglia/macrophages, astrocytes, and neurons	NA	Q6R5P0.fasta	Q6R5P0	926	TLR11 activation is unique in its ability to initiate a parasite-specific innate immune response. TLR11 is unusual in its recognition of T. gondii, because it senses the pathogen by recognizing a profilin released by the microbe rather than by directly interacting with the live parasite	Double-labeling immunohistochemistry, Real-time quantitative polymerase chain reaction (PCR)	24704432	2014	Pubchem_assay
PRRID_1657	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F0X6.fasta	S0F0X6	1063	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1657	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 7 (TLR7)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F0X6.fasta	S0F0X6	1063	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1658	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8a1 (TLR8a1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	NA	NA	NA	antiviral response in salmon	Real-time PCR	24736205	2014	NA
PRRID_1658	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8a1 (TLR8a1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	NA	NA	NA	antiviral response in salmon	Real-time PCR	24736205	2014	NA
PRRID_1659	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8a2 (TLR8a2)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F0N4.fasta	S0F0N4	1035	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1659	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8a2 (TLR8a2)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F0N4.fasta	S0F0N4	1035	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1660	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8b1 (TLR8b1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F1A6.fasta	S0F1A6	1034	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1660	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8b1 (TLR8b1)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F1A6.fasta	S0F1A6	1034	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1661	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8b2 (TLR8b2)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F1D1.fasta	S0F1D1	1036	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1661	type I interferons Click for more detail	Host (Endogenous) (others)	MYTVQSWTCICLIICSMQSVCHCCDWIRHHYGHLSSEYLSLLDQMGGDITKQDAPVFFPTSLYRHIDDAEVEDQVRFLKETIYQITKLFDGNMKSVTWDKKKLDDFLNILERQLENLKSCVSPAMKPEKRLKRYFKKLNKNVLRKMNYSAQAWELIRKETKRHLQRLDILAAQMY	175	Protein	Natural	induces TLR7 and TLR 8 in salmon	Toll-like receptor 8b2 (TLR8b2)	Toll-like receptor (TLR)	Atlantic salmon (Salmo salar)	highest expression in spleen and head kidney and relatively low expression in muscle, liver, gut, heart and gill	NA	S0F1D1.fasta	S0F1D1	1036	antiviral response in salmon	Real-time PCR	24736205	2014	Pubchem_assay
PRRID_1702	Surface Layer Proteins (SLPs) Click for more detail	Clostridium difficile(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Protein	Natural	The binding induces the production of IL-23 via MyD-88 signalling pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Dendritic cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It has the role in the inflammation.	ELISA	25626905	2015	Pubchem_assay
PRRID_1702	Surface Layer Proteins (SLPs) Click for more detail	Clostridium difficile(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Protein	Natural	The binding induces the production of IL-23 via MyD-88 signalling pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Mice (Murine)	Dendritic cells	LRR	Q9QUK6.fasta	Q9QUK6	835	It has the role in the inflammation.	ELISA	25626905	2015	Pubchem_assay
PRRID_1703	Surface Layer Proteins (SLPs) Click for more detail	Clostridium difficile(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Protein	Natural	The binding induces the production of IL-23 via MyD-88 signalling pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Dendritic cells	LRR	O00206.fasta	O00206	839	It has the role in the inflammation.	ELISA	25626905	2015	Pubchem_assay
PRRID_1703	Surface Layer Proteins (SLPs) Click for more detail	Clostridium difficile(Bacteria)	CCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCC	NA	Protein	Natural	The binding induces the production of IL-23 via MyD-88 signalling pathway.	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	Dendritic cells	LRR	O00206.fasta	O00206	839	It has the role in the inflammation.	ELISA	25626905	2015	Pubchem_assay
PRRID_1737	Flagellin Click for more detail	Salmonella (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Mice	Plasma membrane	extracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domain	Q6R5P0.fasta	Q6R5P0	926	Activate NF-KB	NA	27756604	2016	Pubchem_assay
PRRID_1737	Flagellin Click for more detail	Salmonella (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 10 (TLR10)	Toll-like receptor (TLR)	Mice	Plasma membrane	extracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domain	Q6R5P0.fasta	Q6R5P0	926	Activate NF-KB	NA	27756604	2016	Pubchem_assay
PRRID_1738	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	Plasma membrane	extracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domain	Q9JLF7.fasta	Q9JLF7	859	nuclear factor NF- Œ∫B mobilization and the stimulation and secretion of cytokines.	NA	27756604	2016	Pubchem_assay
PRRID_1738	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	Plasma membrane	extracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domain	Q9JLF7.fasta	Q9JLF7	859	nuclear factor NF- Œ∫B mobilization and the stimulation and secretion of cytokines.	NA	27756604	2016	Pubchem_assay
PRRID_1739	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5a/b (TLR5a/b)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	NA	NA	NA	induce IFN expression	NA	27721456	2016	NA
PRRID_1739	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5a/b (TLR5a/b)	Toll-like receptor (TLR)	Zebrafish	endosomes and lysosomes.	extracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domain	NA	NA	NA	induce IFN expression	NA	27721456	2016	NA
PRRID_1740	Flagellin Click for more detail	NA	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9JLF7.fasta	Q9JLF7	859	induce asthma	NA	27120222	2016	Pubchem_assay
PRRID_1740	Flagellin Click for more detail	NA	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice (Murine)	NA	NA	Q9JLF7.fasta	Q9JLF7	859	induce asthma	NA	27120222	2016	Pubchem_assay
PRRID_1747	Gram-negative and Gram-positive bacteria Click for more detail	NA	NA	NA	Protein	Natural	elicit innate immune response	rMrLec	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	26923244	2016	NA
PRRID_1747	Gram-negative and Gram-positive bacteria Click for more detail	NA	NA	NA	Protein	Natural	elicit innate immune response	rMrLec	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	26923244	2016	NA
PRRID_1791	b-1, 3-glucans Click for more detail	Bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Protein	Natural	elicit innate immune response	MnCTLDcp2	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	26208755	2016	NA
PRRID_1791	b-1, 3-glucans Click for more detail	Bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Protein	Natural	elicit innate immune response	MnCTLDcp2	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	26208755	2016	NA
PRRID_1796	b-1, 3-glucans Click for more detail	Bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Protein	Natural	elicit innate immune response	MnCTLDcp3	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	26208755	2016	NA
PRRID_1796	b-1, 3-glucans Click for more detail	Bacteria	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Protein	Natural	elicit innate immune response	MnCTLDcp3	C type Lectin (CTL/CLR)	NA	NA	NA	NA	NA	NA	NA	NA	26208755	2016	NA
PRRID_1830	NA Click for more detail	NA	NA	NA	Protein	Natural	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	26958928	2016	NA
PRRID_1830	NA Click for more detail	NA	NA	NA	Protein	Natural	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	26958928	2016	NA
PRRID_1838	PAMPS Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	CfLRRop-1	Leucine rich repeats (LRR)	NA	NA	NA	NA	NA	NA	NA	NA	26385592	2016	NA
PRRID_1838	PAMPS Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	CfLRRop-1	Leucine rich repeats (LRR)	NA	NA	NA	NA	NA	NA	NA	NA	26385592	2016	NA
PRRID_1845	phenol-soluble modulin Click for more detail	S. aureus (Bacteria)	MEFVAKLFKFFKDLLGKFLGNN	22	Protein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Inhibit proinflammatory cytokines TNF, IL-12 and IL-6	NA	26775799	2016	NA
PRRID_1845	phenol-soluble modulin Click for more detail	S. aureus (Bacteria)	MEFVAKLFKFFKDLLGKFLGNN	22	Protein	Natural	Immunostimulant	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	NA	NA	NA	NA	Inhibit proinflammatory cytokines TNF, IL-12 and IL-6	NA	26775799	2016	NA
PRRID_1887	Œ≤ -1,3-glucan Click for more detail	NA	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Protein	Natural	NA	GRP2	Gastrin-releasing peptide receptor (GRP)	NA	NA	NA	NA	NA	NA	NA	NA	26504233	2016	NA
PRRID_1887	Œ≤ -1,3-glucan Click for more detail	NA	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Protein	Natural	NA	GRP2	Gastrin-releasing peptide receptor (GRP)	NA	NA	NA	NA	NA	NA	NA	NA	26504233	2016	NA
PRRID_1917	Anthrax lethal toxin Click for more detail	NA	NA	NA	Protein	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Rat	Hippocampus	NA	D9I2G4 .fasta	D9I2G4	1218	NLRP1 inflammasome activation in aging	NA	28801521	2017	Pubchem_assay
PRRID_1917	Anthrax lethal toxin Click for more detail	NA	NA	NA	Protein	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Rat	Hippocampus	NA	D9I2G4 .fasta	D9I2G4	1218	NLRP1 inflammasome activation in aging	NA	28801521	2017	Pubchem_assay
PRRID_1918	Anthrax lethal toxin Click for more detail	NA	NA	NA	Protein	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Human	hippocampus (neurons)	NA	Q9C000.fasta	Q9C000	1473	protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairment	NA	28801521	2017	Pubchem_assay
PRRID_1918	Anthrax lethal toxin Click for more detail	NA	NA	NA	Protein	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Human	hippocampus (neurons)	NA	Q9C000.fasta	Q9C000	1473	protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairment	NA	28801521	2017	Pubchem_assay
PRRID_1919	Anthrax lethal toxin Click for more detail	NA	NA	NA	Protein	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Mice	models of AD	NA	Q2LKU9.fasta	Q2LKU9	1182	protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairment	NA	28801521	2017	Pubchem_assay
PRRID_1919	Anthrax lethal toxin Click for more detail	NA	NA	NA	Protein	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Mice	models of AD	NA	Q2LKU9.fasta	Q2LKU9	1182	protein ‚Üë in AD, role in neuronal pyroptosis and cognitive impairment	NA	28801521	2017	Pubchem_assay
PRRID_1920	Anthrax lethal toxin Click for more detail	NA	NA	NA	Protein	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Mice	cortical neurons (cell culture, stroke model)	NA	Q2LKU9.fasta	Q2LKU9	1182	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_1920	Anthrax lethal toxin Click for more detail	NA	NA	NA	Protein	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Mice	cortical neurons (cell culture, stroke model)	NA	Q2LKU9.fasta	Q2LKU9	1182	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_1921	Anthrax lethal toxin Click for more detail	NA	NA	NA	Protein	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Human	Brain	NA	Q9C000.fasta	Q9C000	1473	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_1921	Anthrax lethal toxin Click for more detail	NA	NA	NA	Protein	Natural	NA	Nod-like receptor protein 1 (NLRP1)	NOD-like receptor (NLR)	Human	Brain	NA	Q9C000.fasta	Q9C000	1473	protein ‚Üë in ischemia/reperfusion, role in neuronal cell death and behavioral deficits	NA	28801521	2017	Pubchem_assay
PRRID_1922	Anthrax lethal toxin Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	NALP3/ cryopyrin	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_1922	Anthrax lethal toxin Click for more detail	Bacteria	NA	NA	Protein	Natural	NA	NALP3/ cryopyrin	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_1945	b-1,3-glucans. Click for more detail	Fungi	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Protein	Natural	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	16S rRNA gene analysis	29133884	2017	NA
PRRID_1945	b-1,3-glucans. Click for more detail	Fungi	C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)O	NA	Protein	Natural	NA	NA	NA	NA	NA	NA	NA	NA	NA	NA	16S rRNA gene analysis	29133884	2017	NA
PRRID_1987	CpG motif Click for more detail	NA	NA	NA	Protein	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	human peripheral B¬≠lymphocytes	NA	Q96P20.fasta	Q96P20	1036	NA	NA	29170665	2017	Pubchem_assay
PRRID_1987	CpG motif Click for more detail	NA	NA	NA	Protein	Natural	NA	Nod-like receptor P3 (NLRP3)	NOD-like receptor (NLR)	Human	human peripheral B¬≠lymphocytes	NA	Q96P20.fasta	Q96P20	1036	NA	NA	29170665	2017	Pubchem_assay
PRRID_2035	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	NA	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	NA	NA	O60602.fasta	O60602	858	NA	NA	29066255	2017	Pubchem_assay
PRRID_2035	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	NA	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	NA	NA	O60602.fasta	O60602	858	NA	NA	29066255	2017	Pubchem_assay
PRRID_2036	Flagellin Click for more detail	Gram negative bacteria(Leptospira spp.)	MIINHNLAAINSHRVLKFQNEEVSKNMEKLSSGMRINRAGDDASGLAVSEKMRTQVNGLRQAERNTEDGMSLIQTTEGFLQESNDIIQRIRTLAIQSSNGIYTDEDRQMIQVEVSQLIDEVDRIASQAEFNKMNLLQGDFARGSRATSMWFHLGPNMHQRERVFIATMTARALNLKGQSGDLLSLSTADKSNDAIGTLDAALTRISKQRANLGAYFNRLEHAAKGLMNAYENTQASESRIRDADMAEETVAFTKNQILVQSGTAMLAQANVRPQGVLSLLR	281	Protein	Natural	NA	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9JLF7.fasta	Q9JLF7	859	NA	NA	29038956	2017	Pubchem_assay
PRRID_2036	Flagellin Click for more detail	Gram negative bacteria(Leptospira spp.)	MIINHNLAAINSHRVLKFQNEEVSKNMEKLSSGMRINRAGDDASGLAVSEKMRTQVNGLRQAERNTEDGMSLIQTTEGFLQESNDIIQRIRTLAIQSSNGIYTDEDRQMIQVEVSQLIDEVDRIASQAEFNKMNLLQGDFARGSRATSMWFHLGPNMHQRERVFIATMTARALNLKGQSGDLLSLSTADKSNDAIGTLDAALTRISKQRANLGAYFNRLEHAAKGLMNAYENTQASESRIRDADMAEETVAFTKNQILVQSGTAMLAQANVRPQGVLSLLR	281	Protein	Natural	NA	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Mice	NA	Leucine-rich Repeat (LRR) Domain	Q9JLF7.fasta	Q9JLF7	859	NA	NA	29038956	2017	Pubchem_assay
PRRID_2037	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Induce secretion of cytokines, chemokines and co-stimulatory molecules from T cells	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60602.fasta	O60602	858	NA	NA	29028369	2017	Pubchem_assay
PRRID_2037	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Induce secretion of cytokines, chemokines and co-stimulatory molecules from T cells	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	NA	Leucine-rich Repeat (LRR) Domain	O60602.fasta	O60602	858	NA	NA	29028369	2017	Pubchem_assay
PRRID_2038	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Bacterial infection	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	oral squamous cell carcinomas	Leucine-rich Repeat (LRR) Domain	O60602.fasta	O60602	858	NA	NA	28982847	2017	Pubchem_assay
PRRID_2038	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Bacterial infection	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	oral squamous cell carcinomas	Leucine-rich Repeat (LRR) Domain	O60602.fasta	O60602	858	NA	NA	28982847	2017	Pubchem_assay
PRRID_2039	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Innate immunity elicitor	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Membrane	D0 domain	O60602.fasta	O60602	858	recognizes a conserved region within the D1 domain of flagellin, crucial for the interaction between subunits in the flagellum and for bacterial motility.	Co-immunoprecipitataion Binding assay	28827825	2017	Pubchem_assay
PRRID_2039	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Innate immunity elicitor	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	Human	Membrane	D0 domain	O60602.fasta	O60602	858	recognizes a conserved region within the D1 domain of flagellin, crucial for the interaction between subunits in the flagellum and for bacterial motility.	Co-immunoprecipitataion Binding assay	28827825	2017	Pubchem_assay
PRRID_2040	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Innate immunity elicitor	NAIP5/NLRC4 inflammasome receptor	NOD-like receptor (NLR)	Human	intracellular	NA	NA	NA	NA	Recognizes flagellin and bind it.	Co-immunoprecipitataion Binding assay	28827825	2017	NA
PRRID_2040	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Innate immunity elicitor	NAIP5/NLRC4 inflammasome receptor	NOD-like receptor (NLR)	Human	intracellular	NA	NA	NA	NA	Recognizes flagellin and bind it.	Co-immunoprecipitataion Binding assay	28827825	2017	NA
PRRID_2041	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	NA	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2041	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	NA	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2042	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	NA	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2042	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	NA	Nod-like receptor C4 (NLRC4)	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	28801521	2017	NA
PRRID_2043	Flagellin Click for more detail	Vibrio (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Leulectin	Pattern recognition receptor (PRR)	Marsupenaeus japonicus	Hemocytes	LRR	NA	NA	NA	Hemocytic Phagocytosis	Pull- down and far-Western assays	28258197	2017	NA
PRRID_2043	Flagellin Click for more detail	Vibrio (Bacteria)	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	Leulectin	Pattern recognition receptor (PRR)	Marsupenaeus japonicus	Hemocytes	LRR	NA	NA	NA	Hemocytic Phagocytosis	Pull- down and far-Western assays	28258197	2017	NA
PRRID_2044	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	EcToll-like receptor 5M (TLR5M)	Toll-like receptor (TLR)	Epinephelus coioides	Spleen	LRR domain, a transmembrane region and a TIR domain	NA	NA	NA	recognize flagellin and activate NF-Œ∫B,	qRT-PCR	28159696	2017	NA
PRRID_2044	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	EcToll-like receptor 5M (TLR5M)	Toll-like receptor (TLR)	Epinephelus coioides	Spleen	LRR domain, a transmembrane region and a TIR domain	NA	NA	NA	recognize flagellin and activate NF-Œ∫B,	qRT-PCR	28159696	2017	NA
PRRID_2045	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	EcToll-like receptor 5s (TLR5s)	Toll-like receptor (TLR)	Epinephelus coioides	Liver	LRR domain	NA	NA	NA	recognize flagellin and activate NF-Œ∫B,	qRT-PCR	28159696	2017	NA
PRRID_2045	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	EcToll-like receptor 5s (TLR5s)	Toll-like receptor (TLR)	Epinephelus coioides	Liver	LRR domain	NA	NA	NA	recognize flagellin and activate NF-Œ∫B,	qRT-PCR	28159696	2017	NA
PRRID_2046	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	OfToll-like receptor 5 (TLR5)M	Toll-like receptor (TLR)	Oplegnathus fasciatus	Liver	extracellular domain with 22 leucine rich repeats (LRR), a transmembrane domain and an 32 endodomain with TIR motif.	NA	NA	NA	responds to flagellin challenge and activates NF-Œ∫B	qRT-PCR	28111358	2017	NA
PRRID_2046	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	Immunostimulant	OfToll-like receptor 5 (TLR5)M	Toll-like receptor (TLR)	Oplegnathus fasciatus	Liver	extracellular domain with 22 leucine rich repeats (LRR), a transmembrane domain and an 32 endodomain with TIR motif.	NA	NA	NA	responds to flagellin challenge and activates NF-Œ∫B	qRT-PCR	28111358	2017	NA
PRRID_2047	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	NA	IPAF	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2047	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	NA	IPAF	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2048	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	NA	NAIP	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2048	Flagellin Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	NA	NAIP	NOD-like receptor (NLR)	NA	NA	NA	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2049	Flagellin (Legionella recognized) Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	NA	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2049	Flagellin (Legionella recognized) Click for more detail	Bacteria	MAQVINTNSLSLLTQNNLNKSQSALGTAIERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDTLNVQQKYKVSDTAATVTGYADTTIALDNSTFKASATGLGGTDQKIDGDLKFDDTTGKYYAKVTVTGGTGKDGYYEVSVDKTNGEVTLAGGATSPLTGGLPATATEDVKNVQVANADLTEAKAALTAAGVTGTASVVKMSYTDNNGKTIDGGLAVKVGDDYYSATQNKDGSISINTTKYTADDGTSKTALNKLGGADGKTEVVSIGGKTYAASKAEGHNFKAQPDLAEAAATTTENPLQKIDAALAQVDTLRSDLGAVQNRFNSAITNLGNTVNNLTSARSRIEDSDYATEVSNMSRAQILQQAGTSVLAQANQVPQNVLSLLR	495	Protein	Natural	NA	Toll-like receptor 5 (TLR5)	Toll-like receptor (TLR)	NA	NA	Leucine-rich Repeat (LRR) Domain	NA	NA	NA	NA	NA	28063015	2017	NA
PRRID_2162	HMGB1 Click for more detail	nucleus, autophagosome (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	extracellular domain formed by three immunoglobulin domains (V-C1-C2), a single transmembrane domain and cytosolic portions.	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2162	HMGB1 Click for more detail	nucleus, autophagosome (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 2 (TLR2)	Toll-like receptor (TLR)	NA	NA	extracellular domain formed by three immunoglobulin domains (V-C1-C2), a single transmembrane domain and cytosolic portions.	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2163	HMGB1 Click for more detail	nucleus, autophagosome (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	extracellular domain formed by three immunoglobulin domains (V-C1-C2), a single transmembrane domain and cytosolic portions.	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2163	HMGB1 Click for more detail	nucleus, autophagosome (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	extracellular domain formed by three immunoglobulin domains (V-C1-C2), a single transmembrane domain and cytosolic portions.	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2164	HMGB1 Click for more detail	nucleus, autophagosome (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	extracellular domain formed by three immunoglobulin domains (V-C1-C2), a single transmembrane domain and cytosolic portions.	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2164	HMGB1 Click for more detail	nucleus, autophagosome (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	NA	NA	extracellular domain formed by three immunoglobulin domains (V-C1-C2), a single transmembrane domain and cytosolic portions.	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2165	HMGB1 Click for more detail	nucleus, autophagosome (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	RAGE	Receptor for advanced glycation endproducts (RAGE)	NA	NA	extracellular domain formed by three immunoglobulin domains (V-C1-C2), a single transmembrane domain and cytosolic portions.	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2165	HMGB1 Click for more detail	nucleus, autophagosome (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEEDEEEEEEEEDEDEEEDDDDE	215	Protein	Natural	involved in the resolution and fine-tuning of inflammation by orchestrating the production of anti-inflammatory mediators that are required for the resolution of tissue inflammation and the transition to acquired immunity	RAGE	Receptor for advanced glycation endproducts (RAGE)	NA	NA	extracellular domain formed by three immunoglobulin domains (V-C1-C2), a single transmembrane domain and cytosolic portions.	NA	NA	NA	NA	NA	29290139	2017	NA
PRRID_2166	HMGB1 Click for more detail	Host (Endogenous) (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	translocates to the cytoplasm and extracellular space during cell activation and death	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	gastric epithelial cells	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	NA	NA	29146293	2017	Pubchem_assay
PRRID_2166	HMGB1 Click for more detail	Host (Endogenous) (others)	MGKGDPKKPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYEREMKTYIPPKGETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGEMWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEEDEEDEEDEEEEEDEEDEDEEEDDDDE	215	Protein	Natural	translocates to the cytoplasm and extracellular space during cell activation and death	Toll-like receptor 4 (TLR4)	Toll-like receptor (TLR)	Human	gastric epithelial cells	Leucine-rich Repeat (LRR) Domain	O00206.fasta	O00206	839	NA	NA	29146293	2017	Pubchem_assay

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