Browse result page of PRRDB 2.0

PRRIDName of LigandSource of ligandSequence of LigandLength of Ligand Type of Ligand OccurenceRole of LigandName of ReceptorType of ReeptorSource of the ReceptorLocalizationDomainSequence of ReceptorSwiss prot IDLength of receptorFunction of ReceptorAssay usedPMIDYear of publicationPubchem assay
PRRID_1790Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseMnCTLDcp2C type Lectin (CTL/CLR)NANANANANANANANA262087552016NA
PRRID_1790Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalelicit innate immune responseMnCTLDcp2C type Lectin (CTL/CLR)NANANANANANANANA262087552016NA
PRRID_1791 b-1, 3-glucans

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAProteinNaturalelicit innate immune responseMnCTLDcp2C type Lectin (CTL/CLR)NANANANANANANANA262087552016NA
PRRID_1791 b-1, 3-glucans

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAProteinNaturalelicit innate immune responseMnCTLDcp2C type Lectin (CTL/CLR)NANANANANANANANA262087552016NA
PRRID_1792Lipoteichoic Acid (LTA)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAAmphiphileNaturalelicit innate immune responseMnCTLDcp2C type Lectin (CTL/CLR)NANANANANANANANA262087552016NA
PRRID_1792Lipoteichoic Acid (LTA)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAAmphiphileNaturalelicit innate immune responseMnCTLDcp2C type Lectin (CTL/CLR)NANANANANANANANA262087552016NA
PRRID_1793Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseMnCTLDcp3C type Lectin (CTL/CLR)NANANANANANANANA262087552016NA
PRRID_1793Lipopolysaccharide (LPS)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNALipopolysaccharide (LPS)Naturalelicit innate immune responseMnCTLDcp3C type Lectin (CTL/CLR)NANANANANANANANA262087552016NA
PRRID_1796b-1, 3-glucans

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAProteinNaturalelicit innate immune responseMnCTLDcp3C type Lectin (CTL/CLR)NANANANANANANANA262087552016NA
PRRID_1796b-1, 3-glucans

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAProteinNaturalelicit innate immune responseMnCTLDcp3C type Lectin (CTL/CLR)NANANANANANANANA262087552016NA
PRRID_1797Lipoteichoic Acid (LTA)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAAmphiphileNaturalelicit innate immune responseMnCTLDcp3C type Lectin (CTL/CLR)NANANANANANANANA262087552016NA
PRRID_1797Lipoteichoic Acid (LTA)

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BacteriaCCCCCCCCCCCCCC(=O)OC(CCCCCCCCCCC)CC(=O)OC1C(C(OC(C1OP(=O)(O)O)CO)OCC2C(C(C(C(O2)OP(=O)(O)O)NC(=O)CC(CCCCCCCCCCC)O)OC(=O)CC(CCCCCCCCCCC)O)O)NC(=O)CC(CCCCCCCCCCC)OC(=O)CCCCCCCCCCCNAAmphiphileNaturalelicit innate immune responseMnCTLDcp3C type Lectin (CTL/CLR)NANANANANANANANA262087552016NA
PRRID_1801Mannan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)O)CO)CO)CO)O)O)O)ONAPolysaccharidesNaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAActivate NF-KbNA272933182016NA
PRRID_1801Mannan

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S. cerevisiae (Bacteria)C(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)OC4C(OC(C(C4O)O)O)CO)CO)CO)O)O)O)ONAPolysaccharidesNaturalImmunostimulantToll-like receptor 4 (TLR4)Toll-like receptor (TLR)NANANANANANAActivate NF-KbNA272933182016NA
PRRID_1802mannitol-linked glycerogly- colipid

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M. tuberculosis, S. pneumoniae, K. pneumo- niae, H. pylori, C. albicans, Malassezia spp. (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincleC type Lectin (CTL/CLR)HumanNANANANANARecognition of pathogens and necrotic cells; Induction of cytokine productionNA279999922016NA
PRRID_1802mannitol-linked glycerogly- colipid

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M. tuberculosis, S. pneumoniae, K. pneumo- niae, H. pylori, C. albicans, Malassezia spp. (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincleC type Lectin (CTL/CLR)HumanNANANANANARecognition of pathogens and necrotic cells; Induction of cytokine productionNA279999922016NA
PRRID_1805mannosyl fatty acids

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M. tuberculosis, S. pneumoniae, K. pneumo- niae, H. pylori, C. albicans, Malassezia spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincleC type Lectin (CTL/CLR)HumanNANANANANARecognition of pathogens and necrotic cells; Induction of cytokine productionNA279999922016NA
PRRID_1805mannosyl fatty acids

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M. tuberculosis, S. pneumoniae, K. pneumo- niae, H. pylori, C. albicans, Malassezia spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincleC type Lectin (CTL/CLR)HumanNANANANANARecognition of pathogens and necrotic cells; Induction of cytokine productionNA279999922016NA
PRRID_1810NA

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Propionibacterium acnes (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalrole in acne vulgaris, contributing factor to the progression of prostate cancer and likely through the activation of NF-κB pathwayToll-like receptor 2 (TLR2)homodimersToll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainNANANAinduced NF-κB and AP-1activationELISA280249242016NA
PRRID_1810NA

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Propionibacterium acnes (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalrole in acne vulgaris, contributing factor to the progression of prostate cancer and likely through the activation of NF-κB pathwayToll-like receptor 2 (TLR2)homodimersToll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainNANANAinduced NF-κB and AP-1activationELISA280249242016NA
PRRID_1811NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Megalobrama amblycephalablood, head kidney, spleen and intestine16 leucine-rich repeat (LRR) motifs, an LRR C-terminal, a transmembrane region and a cytoplasmic toll–interleukin-1 receptor (TIR) domain.A0A2H4IQ59.fastaA0A2H4IQ59946Activate NF-KBNA279432922016Pubchem_assay
PRRID_1811NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Megalobrama amblycephalablood, head kidney, spleen and intestine16 leucine-rich repeat (LRR) motifs, an LRR C-terminal, a transmembrane region and a cytoplasmic toll–interleukin-1 receptor (TIR) domain.A0A2H4IQ59.fastaA0A2H4IQ59946Activate NF-KBNA279432922016Pubchem_assay
PRRID_1812NA

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Vibrio harveyi (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPmCLecC type Lectin (CTL/CLR)Penaeus monodonlymphoid organ.carbohydrate recognition domain (CRD)NANANAActivate NF-KBMicrobial binding assay278766222016NA
PRRID_1812NA

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Vibrio harveyi (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantPmCLecC type Lectin (CTL/CLR)Penaeus monodonlymphoid organ.carbohydrate recognition domain (CRD)NANANAActivate NF-KBMicrobial binding assay278766222016NA
PRRID_1813NA

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RS218 (E.coli strain) (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalCauses inflammation and activation of SCR.SSc5DScavenger receptor (SR)HumanMacrophagesFive SRCR modules, and a large C-terminal mucin-like domainA1L4H1.fastaA1L4H11573Pathogen recognition; T cell differentiationMicrobial binding assay277902152016Pubchem_assay
PRRID_1813NA

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RS218 (E.coli strain) (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalCauses inflammation and activation of SCR.SSc5DScavenger receptor (SR)HumanMacrophagesFive SRCR modules, and a large C-terminal mucin-like domainA1L4H1.fastaA1L4H11573Pathogen recognition; T cell differentiationMicrobial binding assay277902152016Pubchem_assay
PRRID_1814NA

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IHE3034 (E.coli strain) (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalCauses inflammation and activation of SCR.SSc5DScavenger receptor (SR)HumanMacrophagesFive SRCR modules, and a large C-terminal mucin-like domainA1L4H1.fastaA1L4H11573Pathogen recognition; T cell differentiationMicrobial binding assay277902152016Pubchem_assay
PRRID_1814NA

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IHE3034 (E.coli strain) (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalCauses inflammation and activation of SCR.SSc5DScavenger receptor (SR)HumanMacrophagesFive SRCR modules, and a large C-terminal mucin-like domainA1L4H1.fastaA1L4H11573Pathogen recognition; T cell differentiationMicrobial binding assay277902152016Pubchem_assay
PRRID_1815NA

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Uropathogenic E.coli (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 10 (TLR10)Toll-like receptor (TLR)Micebladder epithelial cellsextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ6R5P0.fastaQ6R5P0926Activate NF-KBNA277566042016Pubchem_assay
PRRID_1815NA

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Uropathogenic E.coli (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 10 (TLR10)Toll-like receptor (TLR)Micebladder epithelial cellsextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ6R5P0.fastaQ6R5P0926Activate NF-KBNA277566042016Pubchem_assay
PRRID_1816NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1816NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 1 (TLR1)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1817NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1817NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 2 (TLR2)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1818NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1818NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 5 (TLR5)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1819NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1819NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 9 (TLR9)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1820NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 21 (TLR21)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1820NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 21 (TLR21)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1821NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1821NA

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A.hydrophilla(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalBacterial infection, immunostimulantMaToll-like receptor 22 (TLR22)Toll-like receptor (TLR)Megalobrama amblycephalaliver, spleen and head kidneyLRR domain, TM region and TIR domainNANANAActivate NF-KbqRT-PCR276393152016NA
PRRID_1823NA

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Vibrio vulnificus (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantrSsLec1C type Lectin (CTL/CLR)Sebastes schlegeliikidney, liver, spleen and macrophagescarbohydrate-recognition domain (CRD),NANANAActivate NF-KBMicrobial binding assay275699822016NA
PRRID_1823NA

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Vibrio vulnificus (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantrSsLec1C type Lectin (CTL/CLR)Sebastes schlegeliikidney, liver, spleen and macrophagescarbohydrate-recognition domain (CRD),NANANAActivate NF-KBMicrobial binding assay275699822016NA
PRRID_1824NA

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Vibrio ichthyoenteri (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantrSsLec1C type Lectin (CTL/CLR)Sebastes schlegeliiKidney, liver, spleen and macrophagesCarbohydrate recognition domain (CRD)NANANAActivate NF-KBMicrobial binding assay275699822016NA
PRRID_1824NA

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Vibrio ichthyoenteri (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantrSsLec1C type Lectin (CTL/CLR)Sebastes schlegeliiKidney, liver, spleen and macrophagesCarbohydrate recognition domain (CRD)NANANAActivate NF-KBMicrobial binding assay275699822016NA
PRRID_1826NA

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V. anguillarum (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantSmPGRP2Peptidoglycan Recognition Receptor (PGRPs)Scophthalmus maximus liver, spleen, and head-kidney,intestine, gill and skinNANANANAActivate NF-KBqRT-PCR274614222016NA
PRRID_1826NA

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V. anguillarum (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantSmPGRP2Peptidoglycan Recognition Receptor (PGRPs)Scophthalmus maximus liver, spleen, and head-kidney,intestine, gill and skinNANANANAActivate NF-KBqRT-PCR274614222016NA
PRRID_1827NA

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Streptococus agalactiae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalCause bacterial infection, immunostimulantLjToll-like receptor (TLR 5MToll-like receptor (TLR)Lateolabrax japonicasspleen and head-kidneyLRRs (extracellular leucine rich repeats), transmembrane and TIR (Toll/interleukin-1 receptor) domain.NANANAActivate NF-KB, synergistic effect with other TLRs to defense the pathogenic bacteriaqRT-PCR274172332016NA
PRRID_1827NA

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Streptococus agalactiae (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalCause bacterial infection, immunostimulantLjToll-like receptor (TLR 5MToll-like receptor (TLR)Lateolabrax japonicasspleen and head-kidneyLRRs (extracellular leucine rich repeats), transmembrane and TIR (Toll/interleukin-1 receptor) domain.NANANAActivate NF-KB, synergistic effect with other TLRs to defense the pathogenic bacteriaqRT-PCR274172332016NA
PRRID_1828NA

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Vibrio harveyi (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalCause bacterial infection, immunostimulantLjToll-like receptor (TLR 5MToll-like receptor (TLR)Lateolabrax japonicasspleen and head-kidneyLRRs (extracellular leucine rich repeats), transmembrane and TIR (Toll/interleukin-1 receptor) domain.NANANAActivate NF-KBqRT-PCR274172332016NA
PRRID_1828NA

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Vibrio harveyi (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalCause bacterial infection, immunostimulantLjToll-like receptor (TLR 5MToll-like receptor (TLR)Lateolabrax japonicasspleen and head-kidneyLRRs (extracellular leucine rich repeats), transmembrane and TIR (Toll/interleukin-1 receptor) domain.NANANAActivate NF-KBqRT-PCR274172332016NA
PRRID_1829NA

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V. parahaemolyticus (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantCnToll-like receptor 1 (TLR-1)Toll-like receptor (TLR)Chlamys nobilismantle, he- mocytes, gill, kidney, gonad, hepatopancreasfive leucine-rich repeats (LRR), two LRR-C-terminal (LRRCT) motifs and a LRR-N-terminal (LRRNT) motif in the extracellular domain, a transmembrane domain and a Toll/Interleukin-1 Receptor (TIR) of 138NANANAbinds to microbes and act as PRR.qRT-PCR274035922016NA
PRRID_1829NA

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V. parahaemolyticus (Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantCnToll-like receptor 1 (TLR-1)Toll-like receptor (TLR)Chlamys nobilismantle, he- mocytes, gill, kidney, gonad, hepatopancreasfive leucine-rich repeats (LRR), two LRR-C-terminal (LRRCT) motifs and a LRR-N-terminal (LRRNT) motif in the extracellular domain, a transmembrane domain and a Toll/Interleukin-1 Receptor (TIR) of 138NANANAbinds to microbes and act as PRR.qRT-PCR274035922016NA
PRRID_1833NA

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Vibrio anguillarum (Bacteria)NANANANaturalImmunostimulantMmiToll-like receptor 13 (TLR13) Toll-like receptor (TLR)miiuy croakerliver, spleen, and kidney,TIR domainNANANAactives the ISRE Luciferase assay269527672016NA
PRRID_1833NA

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Vibrio anguillarum (Bacteria)NANANANaturalImmunostimulantMmiToll-like receptor 13 (TLR13) Toll-like receptor (TLR)miiuy croakerliver, spleen, and kidney,TIR domainNANANAactives the ISRE Luciferase assay269527672016NA
PRRID_1836O-linked mannobiose-rich glycoprotein

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M. tuberculosis, S. enterica, S. mansoni, C. albicans, A. fumigatus, Malassezia spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-2C type Lectin (CTL/CLR)HumanNANAQ6EIG7.fastaQ6EIG7209Pathogen recognition; antigen uptakeNA279999922016Pubchem_assay
PRRID_1836O-linked mannobiose-rich glycoprotein

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M. tuberculosis, S. enterica, S. mansoni, C. albicans, A. fumigatus, Malassezia spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-2C type Lectin (CTL/CLR)HumanNANAQ6EIG7.fastaQ6EIG7209Pathogen recognition; antigen uptakeNA279999922016Pubchem_assay
PRRID_1837Pam3CSk4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)ZebrafishPlasma membraneextracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainF1QWS9.fastaF1QWS9818induce IFN expressionNA277214562016Pubchem_assay
PRRID_1837Pam3CSk4

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BacteriaCCCCCCCCCCCCCCCC(=O)NC(CSCC(COC(=O)CCCCCCCCCCCCCCC)OC(=O)CCCCCCCCCCCCCCC)C(=O)NC(CO)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)NC(CCCCN)C(=O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)ZebrafishPlasma membraneextracellular (or intra- endosomal) ligand-binding domain with a leucine-rich repeat (LRR) motif and a cytoplasmic signaling Toll/Interleukin-1 (IL-1) receptor homology (TIR) domainF1QWS9.fastaF1QWS9818induce IFN expressionNA277214562016Pubchem_assay
PRRID_1838PAMPS

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BacteriaNANAProteinNaturalNACfLRRop-1Leucine rich repeats (LRR)NANANANANANANANA263855922016NA
PRRID_1838PAMPS

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BacteriaNANAProteinNaturalNACfLRRop-1Leucine rich repeats (LRR)NANANANANANANANA263855922016NA
PRRID_1839Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalBacterial infectionCgPGRPS4Peptidoglycan Recognition Receptor (PGRPs)Crassostrea gigasCytoplasmone typical PGRP/amidase domainNANANAActivate NF-kBPAMPs binding assay280420812016NA
PRRID_1839Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalBacterial infectionCgPGRPS4Peptidoglycan Recognition Receptor (PGRPs)Crassostrea gigasCytoplasmone typical PGRP/amidase domainNANANAActivate NF-kBPAMPs binding assay280420812016NA
PRRID_1841Peptidoglycan (PGN)

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A.hydrophilla(Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalCause bacterial infection, immunostimulantPcFBN1FREPProcambarus clarkiihepatopancreas and hemocyteFBG domain in C-terminal and a putative signal peptide of 19 amino acids in N-terminal.NANANAtrigger complement system via the lectin-dependent pathway.Ligand binding assay274172292016NA
PRRID_1841Peptidoglycan (PGN)

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A.hydrophilla(Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalCause bacterial infection, immunostimulantPcFBN1FREPProcambarus clarkiihepatopancreas and hemocyteFBG domain in C-terminal and a putative signal peptide of 19 amino acids in N-terminal.NANANAtrigger complement system via the lectin-dependent pathway.Ligand binding assay274172292016NA
PRRID_1842Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalImmunostimulantHexokinasePattern recognition receptor (PRR)HumanMacrophages, Dendritic cellsNAP52789.fastaP52789917Metabolic enzyme, Trigger NLRP3 Inflammasome Activation and IL-1b ProductionProximity Ligation assay273743312016Pubchem_assay
PRRID_1842Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalImmunostimulantHexokinasePattern recognition receptor (PRR)HumanMacrophages, Dendritic cellsNAP52789.fastaP52789917Metabolic enzyme, Trigger NLRP3 Inflammasome Activation and IL-1b ProductionProximity Ligation assay273743312016Pubchem_assay
PRRID_1843Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalImmunostimulantCgSiglec-1Pattern recognition receptor (PRR)Crassostrea gigasNACRD or C1q domainNANANAact as a bridge molecule between invader recognition and signal transduction cascade, and modulate the immune response by inhibiting various important pro- cesses of immunity in oyster.NA270326022016NA
PRRID_1843Peptidoglycan (PGN)

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BacteriaCC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalImmunostimulantCgSiglec-1Pattern recognition receptor (PRR)Crassostrea gigasNACRD or C1q domainNANANAact as a bridge molecule between invader recognition and signal transduction cascade, and modulate the immune response by inhibiting various important pro- cesses of immunity in oyster.NA270326022016NA
PRRID_1844Peptidoglycan (PGN)

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S. aureus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalIt enhances microbe agglutination and haemocytes encapsulation.GalectinPattern recognition receptor (PRR)Eriocheir sinensisHepatopancreasCRDNANANAIt provies immune defense against invading microbes.ELISA270951742016NA
PRRID_1844Peptidoglycan (PGN)

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S. aureus (Bacteria)CC(C(=O)O)OC1C(C(OC(C1O)CO)O)NNAPeptidoglycanNaturalIt enhances microbe agglutination and haemocytes encapsulation.GalectinPattern recognition receptor (PRR)Eriocheir sinensisHepatopancreasCRDNANANAIt provies immune defense against invading microbes.ELISA270951742016NA
PRRID_1845phenol-soluble modulin

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S. aureus (Bacteria)MEFVAKLFKFFKDLLGKFLGNN22ProteinNaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAInhibit proinflammatory cytokines TNF, IL-12 and IL-6NA267757992016NA
PRRID_1845phenol-soluble modulin

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S. aureus (Bacteria)MEFVAKLFKFFKDLLGKFLGNN22ProteinNaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAInhibit proinflammatory cytokines TNF, IL-12 and IL-6NA267757992016NA
PRRID_1861PSM

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Staphylococcus epidermidis (Bacteria)NANANANaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAInduce cytokine releaseNA267757992016NA
PRRID_1861PSM

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Staphylococcus epidermidis (Bacteria)NANANANaturalImmunostimulantToll-like receptor 2 (TLR2)Toll-like receptor (TLR)NANANANANANAInduce cytokine releaseNA267757992016NA
PRRID_1875TDM

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M. tuberculosis, S. pneumoniae, K. pneumo- niae, H. pylori, C. albicans, Malassezia spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincleC type Lectin (CTL/CLR)HumanNANANANANARecognition of pathogens and necrotic cells; Induction of cytokine productionNA279999922016NA
PRRID_1875TDM

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M. tuberculosis, S. pneumoniae, K. pneumo- niae, H. pylori, C. albicans, Malassezia spp.(Bacteria)NANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincleC type Lectin (CTL/CLR)HumanNANANANANARecognition of pathogens and necrotic cells; Induction of cytokine productionNA279999922016NA
PRRID_1878Triacetylated lipoproteins

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Mycobacteria (Bacteria)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalImmunostimulantToll-like receptor 1 (TLR1)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ9EPQ1.fastaQ9EPQ1795increase TNF-a and IL-6NA277566042016Pubchem_assay
PRRID_1878Triacetylated lipoproteins

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Mycobacteria (Bacteria)CC1CCC2(C(C3C(O2)CC4C3(CCC5C4CCC6C5(CCC(C6)O)C)C)C)NC1NALipoproteinNaturalImmunostimulantToll-like receptor 1 (TLR1)Toll-like receptor (TLR)MicePlasma membraneextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ9EPQ1.fastaQ9EPQ1795increase TNF-a and IL-6NA277566042016Pubchem_assay
PRRID_1882Unmethylated CpG DNA

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Bacterial, viral genomeNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceDendritic cellextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ9NR96.fastaQ9NR961032dendritic cells activation for innate and adaptive immunityNA277566042016Pubchem_assay
PRRID_1882Unmethylated CpG DNA

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Bacterial, viral genomeNANAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantToll-like receptor 9 (TLR9)Toll-like receptor (TLR)MiceDendritic cellextracellular domain containing leucine-rich repeats and an intracellular domain that contains a conserved region called the Toll/IL-1 receptor (TIR) domain and the trans membrane domainQ9NR96.fastaQ9NR961032dendritic cells activation for innate and adaptive immunityNA277566042016Pubchem_assay
PRRID_1884α-Mannose

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M. tuberculosis, S. enterica, S. mansoni, C. albicans, A. fumigatus, Malassezia spp.(Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-2C type Lectin (CTL/CLR)HumanNANAQ6EIG7.fastaQ6EIG7209Pathogen recognition; antigen uptakeNA279999922016Pubchem_assay
PRRID_1884α-Mannose

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M. tuberculosis, S. enterica, S. mansoni, C. albicans, A. fumigatus, Malassezia spp.(Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantDectin-2C type Lectin (CTL/CLR)HumanNANAQ6EIG7.fastaQ6EIG7209Pathogen recognition; antigen uptakeNA279999922016Pubchem_assay
PRRID_1885α-Mannose

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M. tuberculosis, S. pneumoniae, K. pneumo- niae, H. pylori, C. albicans, Malassezia spp.(Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincleC type Lectin (CTL/CLR)HumanNANANANANARecognition of pathogens and necrotic cells; Induction of cytokine productionNA279999922016NA
PRRID_1885α-Mannose

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M. tuberculosis, S. pneumoniae, K. pneumo- niae, H. pylori, C. albicans, Malassezia spp.(Bacteria)C(C1C(C(C(C(O1)O)O)O)O)ONAPattern-associated molecular patterns (PAMPs)NaturalImmunostimulantMincleC type Lectin (CTL/CLR)HumanNANANANANARecognition of pathogens and necrotic cells; Induction of cytokine productionNA279999922016NA
PRRID_189323S rRNA

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BacteriaNANANANaturalNAToll-like receptor 13 (TLR13)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ6R5N8.fastaQ6R5N8991NALuciferase assay293077702017Pubchem_assay
PRRID_189323S rRNA

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BacteriaNANANANaturalNAToll-like receptor 13 (TLR13)Toll-like receptor (TLR)MiceNALeucine-rich Repeat (LRR) DomainQ6R5N8.fastaQ6R5N8991NALuciferase assay293077702017Pubchem_assay
PRRID_1906Aeromonas hydrophila

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalPathogenic infectionCcToll-like receptor (TLR18)Toll-like receptor (TLR)Common Carp (Cyprinus carpio L)head kidney, foregut, hindgut and skin.LRR motifs, a transmembrane region and a TIR domainNANANANAReal-time PCR291113942017NA
PRRID_1906Aeromonas hydrophila

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BacteriaNANAPattern-associated molecular patterns (PAMPs)NaturalPathogenic infectionCcToll-like receptor (TLR18)Toll-like receptor (TLR)Common Carp (Cyprinus carpio L)head kidney, foregut, hindgut and skin.LRR motifs, a transmembrane region and a TIR domainNANANANAReal-time PCR291113942017NA
PRRID_1907Ag85 complex

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanTHP‚Äê1 macrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017Pubchem_assay
PRRID_1907Ag85 complex

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsToll-like receptor 2 (TLR2)Toll-like receptor (TLR)HumanTHP‚Äê1 macrophagesLeucine-rich Repeat (LRR) DomainO60603.fastaO60603784NATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017Pubchem_assay
PRRID_1908Ag85 complex

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsCR3Complement ReceptorHumanTHP‚Äê1 macrophagesNANANANANATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017NA
PRRID_1908Ag85 complex

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Mycobacteria (Bacteria)NANAPattern-associated molecular patterns (PAMPs)Naturalcauses tuberculosis-like systemic infection in sh and in other ectothermsCR3Complement ReceptorHumanTHP‚Äê1 macrophagesNANANANANATHP‚Äê1 cell culture ,FACS LSR II BD ow cytom- eter ,ELISA291833332017NA
PRRID_1922Anthrax lethal toxin

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BacteriaNANAProteinNaturalNANALP3/ cryopyrinNOD-like receptor (NLR)NANANANANANANANA280630152017NA
PRRID_1922Anthrax lethal toxin

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BacteriaNANAProteinNaturalNANALP3/ cryopyrinNOD-like receptor (NLR)NANANANANANANANA280630152017NA
PRRID_1938b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlycoproteinNaturalNABmbGRP1Gastrin-releasing peptide receptor (GRP)Bombyx moriNANANANANANANA292294432017NA
PRRID_1938b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlycoproteinNaturalNABmbGRP1Gastrin-releasing peptide receptor (GRP)Bombyx moriNANANANANANANA292294432017NA
PRRID_1939b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlycoproteinNaturalNABmbGRP2Gastrin-releasing peptide receptor (GRP)Bombyx moriNANANANANANABacterial binding assay292294432017NA
PRRID_1939b-1,3-glucans.

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BacteriaC(C1C(C(C(C(O1)OC2C(OC(C(C2O)O)OC3C(OC(C(C3O)O)O)CO)CO)O)O)O)ONAGlycoproteinNaturalNABmbGRP2Gastrin-releasing peptide receptor (GRP)Bombyx moriNANANANANANABacterial binding assay292294432017NA